World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
10997
World Ranking
16598
National Ranking
1189

Overview

Takao Iwawaki is affiliated with Kanazawa Medical University in Japan and has produced extensive research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields including Cell Biology, Molecular Biology, Immunology, Surgery, and Epidemiology.

The scientist's research covers a variety of topics, with a strong focus on Endoplasmic Reticulum Stress and Disease. Additional main topics include Autophagy in Disease and Therapy, Pancreatic function and diabetes, Renal Diseases and Glomerulopathies, Immune Cell Function and Interaction, Immune cells in cancer, and RNA regulation and disease.

Takao Iwawaki has published multiple recent papers, including:

  • IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival, 2020, PLoS Biology
  • Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions, 2020, Nature Cell Biology
  • Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model, 2020, Scientific Reports
  • Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α, 2020, Cell Death and Differentiation
  • Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression, 2022, EMBO Molecular Medicine

Their frequent co-authors include Ryoko Akai, Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, and Sei-ichiro Motegi. These collaborations have contributed to the volume and diversity of their academic output.

Takao Iwawaki regularly publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, Journal of the American Society of Nephrology, Nature Cell Biology, and Nature Communications. Notably, bioRxiv features the highest number of their publications among these journals.

Best Publications

  • Paneth cells as a site of origin for intestinal inflammation

    Timon E. Adolph;Michal F. Tomczak;Lukas Niederreiter;Hyun Jeong Ko;Hyun Jeong Ko

  • Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice

    Michiko Saito;Takao Iwawaki;Choji Taya;Hiromichi Yonekawa

  • A transgenic mouse model for monitoring endoplasmic reticulum stress

    Takao Iwawaki;Ryoko Akai;Ryoko Akai;Kenji Kohno;Masayuki Miura;Masayuki Miura

  • Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance

    Mitsuhisa Tabata;Tsuyoshi Kadomatsu;Shigetomo Fukuhara;Keishi Miyata

  • Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

    Takao Iwawaki;Ryoko Akai;Shinya Yamanaka;Kenji Kohno

  • Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.

    Takao Iwawaki;Akira Hosoda;Tetsuo Okuda;Yusuke Kamigori

  • Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

    Jae-Seon So;Kyu Yeon Hur;Margarite Tarrio;Vera Ruda

  • Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

    Takafumi Suzuki;Aki Muramatsu;Ryota Saito;Tatsuro Iso

  • The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

    Fabiola Osorio;Simon J Tavernier;Eik Hoffmann;Yvan Saeys

  • The Endoplasmic Reticulum Stress-C/EBP Homologous Protein Pathway-Mediated Apoptosis in Macrophages Contributes to the Instability of Atherosclerotic Plaques

    Hiroto Tsukano;Tomomi Gotoh;Motoyoshi Endo;Keishi Miyata

  • Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

    Daisuke Oikawa;Yukio Kimata;Kenji Kohno;Takao Iwawaki

  • IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.

    Shengyi Sun;Guojun Shi;Haibo Sha;Yewei Ji

  • Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA

    Kota Yanagitani;Yusuke Imagawa;Takao Iwawaki;Akira Hosoda

  • Identification of a consensus element recognized and cleaved by IRE1α

    Daisuke Oikawa;Mio Tokuda;Akira Hosoda;Takao Iwawaki

  • Negative feedback by IRE1β optimizes mucin production in goblet cells

    Akio Tsuru;Naoko Fujimoto;Satsuki Takahashi;Michiko Saito

  • IRE1 Signaling Exacerbates Alzheimer's Disease Pathogenesis

    Claudia Duran-Aniotz;Victor Hugo Cornejo;Sandra Espinoza;Álvaro O Ardiles

  • CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

    Dotan Uzi;Liran Barda;Viviana Scaiewicz;Maya Mills

  • Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.

    M Ri;E Tashiro;D Oikawa;S Shinjo

  • C/EBP Homologous Protein Deficiency Attenuates Myocardial Reperfusion Injury by Inhibiting Myocardial Apoptosis and Inflammation

    Yuji Miyazaki;Koichi Kaikita;Motoyoshi Endo;Eiji Horio

  • Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

    Megan M. Robblee;Charles C. Kim;Jess Porter Abate;Martin Valdearcos

Frequent Co-Authors

Kenji Kohno
Kenji Kohno Nara Institute of Science and Technology
Osamu Ishikawa
Osamu Ishikawa Gunma University
Laurie H. Glimcher
Laurie H. Glimcher Harvard University
Yuichi Oike
Yuichi Oike Kumamoto University
Jun-ichi Miyazaki
Jun-ichi Miyazaki Osaka University
Masayuki Miura
Masayuki Miura University of Tokyo
Bart N. Lambrecht
Bart N. Lambrecht Ghent University
Yoshito Kumagai
Yoshito Kumagai University of Tsukuba
Sophie Janssens
Sophie Janssens Ghent University
Philip Rosenstiel
Philip Rosenstiel Kiel University

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