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Ivan Zanoni

Ivan Zanoni

Boston Children's Hospital
United States

Overview

What is he best known for?

The fields of study he is best known for:

Immune system
Gene
Cytokine

The scientist’s investigation covers issues in Cell biology, Innate immune system, Signal transduction, Pattern recognition receptor and Receptor. His Cell biology research is multidisciplinary, incorporating perspectives in Dendritic cell and Interferon gamma. His Innate immune system research incorporates themes from Acquired immune system, Interleukin 12, Priming and CD14.

In his study, Signal transducing adaptor protein is strongly linked to NFAT, which falls under the umbrella field of Signal transduction. His Pattern recognition receptor study results in a more complete grasp of Immune system. His Immune system research is multidisciplinary, incorporating elements of RNA, Virus, Viral load and Pathogenesis.

His most cited work include:

Innate immune pattern recognition: a cell biological perspective. (653 citations)
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4 (566 citations)
CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation (239 citations)

What are the main themes of his work throughout his whole career to date?

Ivan Zanoni mainly investigates Cell biology, Immunology, Innate immune system, Immune system and Pattern recognition receptor. His research in Cell biology intersects with topics in Oxidative stress and Receptor, CD14. His study in Innate immune system is interdisciplinary in nature, drawing from both Acquired immune system, Lipopolysaccharide, NFAT and TLR4.

His research investigates the connection between Acquired immune system and topics such as Phagocyte that intersect with problems in Inflammasome. His Immune system research integrates issues from Pathogen and Microbiology. He has researched Pattern recognition receptor in several fields, including T cell, Antigen-presenting cell and Transcription factor.

He most often published in these fields:

Cell biology (57.66%)
Immunology (49.64%)
Innate immune system (40.88%)

What were the highlights of his more recent work (between 2019-2021)?

Cell biology (57.66%)
Immune system (41.61%)
Immunology (49.64%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cell biology, Immune system, Immunology, Innate immune system and Inflammation. His Cell biology study incorporates themes from Pathogen, Receptor, Inflammasome, Phagocyte and Endogeny. His study in the fields of Viral load, Pathogenesis and Virus under the domain of Immunology overlaps with other disciplines such as Respiratory tract and Respiratory tract infections.

Ivan Zanoni is interested in Pattern recognition receptor, which is a branch of Innate immune system. In his research on the topic of Pattern recognition receptor, C-type lectin, Candida albicans and Lectin is strongly related with Acquired immune system. Ivan Zanoni works mostly in the field of Inflammation, limiting it down to concerns involving CD14 and, occasionally, Chaperone and Receptor complex.

Between 2019 and 2021, his most popular works were:

Type III interferons disrupt the lung epithelial barrier upon viral recognition. (98 citations)
Type III interferons disrupt the lung epithelial barrier upon viral recognition. (98 citations)
COVID-19 and emerging viral infections: The case for interferon lambda. (96 citations)

In his most recent research, the most cited papers focused on:

Immune system
Gene
Cytokine

His primary areas of study are Immune system, Cell biology, Immunology, Pneumonia and Pathogenesis. The study incorporates disciplines such as Barrier integrity, Pathogen, Receptor and Pathogenic organism in addition to Immune system. He connects Cell biology with Glutamine in his study.

His study on Virus, Viral load and Innate immune system is often connected to Respiratory tract as part of broader study in Immunology. His study of Pneumonia brings together topics like 2019-20 coronavirus outbreak, Betacoronavirus, Pandemic, Severe acute respiratory syndrome coronavirus 2 and Interferon. His Pathogenesis research is multidisciplinary, relying on both Inflammation and CD14.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Innate immune pattern recognition: a cell biological perspective.

Sky W. Brubaker;Kevin S. Bonham;Ivan Zanoni;Jonathan C. Kagan.
Annual Review of Immunology (2015)

929 Citations

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

Ivan Zanoni;Renato Ostuni;Lorri R. Marek;Simona Barresi.
Cell (2011)

890 Citations

CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

Ivan Zanoni;Renato Ostuni;Giusy Capuano;Maddalena Collini.
Nature (2009)

366 Citations

A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation

Francesca Granucci;Ivan Zanoni;Norman Pavelka;Serani L.H. van Dommelen.
Journal of Experimental Medicine (2004)

262 Citations

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

Ivan Zanoni;Ivan Zanoni;Yunhao Tan;Marco Di Gioia;Achille Broggi.
Science (2016)

251 Citations

Type III interferons disrupt the lung epithelial barrier upon viral recognition.

Achille Broggi;Sreya Ghosh;Benedetta Sposito;Benedetta Sposito;Roberto Spreafico.
Science (2020)

238 Citations

Role of CD14 in host protection against infections and in metabolism regulation.

Ivan Zanoni;Francesca Granucci.
Frontiers in Cellular and Infection Microbiology (2013)

230 Citations

Deciphering the complexity of Toll-like receptor signaling

Renato Ostuni;Ivan Zanoni;Francesca Granucci.
Cellular and Molecular Life Sciences (2010)

188 Citations

COVID-19 and emerging viral infections: The case for interferon lambda.

Ludmila Prokunina-Olsson;Noémie Alphonse;Noémie Alphonse;Ruth E. Dickenson;Joan E. Durbin.
Journal of Experimental Medicine (2020)

186 Citations

IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function

Achille Broggi;Yunhao Tan;Francesca Granucci;Ivan Zanoni;Ivan Zanoni.
Nature Immunology (2017)

169 Citations

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Frequent Co-Authors

External Links

Personal Website for Ivan Zanoni