D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 75 Citations 17,952 312 World Ranking 3374 National Ranking 1733

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His primary areas of study are Biochemistry, Small molecule, High-throughput screening, Structure–activity relationship and Drug discovery. The study of Biochemistry is intertwined with the study of Stereochemistry in a number of ways. His Small molecule research includes themes of Base excision repair, Molecular biology, FOXM1, Forkhead Transcription Factors and Transcription.

His High-throughput screening research is multidisciplinary, incorporating perspectives in Autofluorescence, Nanotechnology, Beta-Lactamase Inhibitors, Fluorescence spectrometry and Combinatorial chemistry. His work deals with themes such as Toxicity, Stress response pathway, Molecular model and Pharmacology, which intersect with Structure–activity relationship. His research in Drug discovery intersects with topics in Computational biology, Cell function and Molecular targets.

His most cited work include:

  • Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. (623 citations)
  • High-throughput screening assays for the identification of chemical probes (458 citations)
  • Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen (396 citations)

What are the main themes of his work throughout his whole career to date?

Anton Simeonov mainly investigates Biochemistry, Small molecule, Computational biology, Drug discovery and High-throughput screening. Anton Simeonov interconnects Molecular biology and Stereochemistry in the investigation of issues within Biochemistry. Anton Simeonov combines subjects such as DNA damage and Cell biology with his study of Small molecule.

In most of his Computational biology studies, his work intersects topics such as High-Throughput Screening Assays.

He most often published in these fields:

  • Biochemistry (28.67%)
  • Small molecule (17.25%)
  • Computational biology (11.42%)

What were the highlights of his more recent work (between 2019-2021)?

  • Computational biology (11.42%)
  • Drug (6.53%)
  • Pharmacology (10.02%)

In recent papers he was focusing on the following fields of study:

Computational biology, Drug, Pharmacology, Drug repositioning and Cancer research are his primary areas of study. The study incorporates disciplines such as Viral replication, In silico, Small molecule and Proteasome in addition to Computational biology. His Small molecule study incorporates themes from Phosphatidylinositol, Kinase, Phosphatidylinositol 5-phosphate, Structure–activity relationship and Drug discovery.

His research in the fields of Combination therapy overlaps with other disciplines such as Camostat. His Cytotoxicity research entails a greater understanding of Biochemistry. The concepts of his Biochemistry study are interwoven with issues in Schistosomiasis and Praziquantel.

Between 2019 and 2021, his most popular works were:

  • Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 (196 citations)
  • Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2. (37 citations)
  • Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses (34 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His primary areas of investigation include Drug repositioning, Severe acute respiratory syndrome coronavirus 2, Pharmacology, Clinical trial and Coronavirus. His research integrates issues of Cytopathic effect and Approved drug in his study of Drug repositioning. His work deals with themes such as Pandemic and Emergency Use Authorization, which intersect with Severe acute respiratory syndrome coronavirus 2.

His Pharmacology research is multidisciplinary, relying on both Proteases, Gabexate, Nafamostat, Protease and Viral entry. In his work, Biochemistry is strongly intertwined with In vivo, which is a subfield of Cell culture. He interconnects Luciferase, Chemical structure and High-throughput screening in the investigation of issues within Computational biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

James Inglese;Douglas S. Auld;Ajit Jadhav;Ronald L. Johnson.
Proceedings of the National Academy of Sciences of the United States of America (2006)

758 Citations

High-throughput screening assays for the identification of chemical probes

James Inglese;Ronald L Johnson;Anton Simeonov;Menghang Xia.
Nature Chemical Biology (2007)

634 Citations

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

Susanne A.I. Seidel;Patricia M. Dijkman;Wendy A. Lea;Geert van den Bogaart.
Methods (2013)

584 Citations

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

Richard T. Eastman;Jacob S. Roth;Jacob S. Roth;Kyle R. Brimacombe;Anton Simeonov.
ACS central science (2020)

573 Citations

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

Miao Xu;Emily M. Lee;Zhexing Wen;Yichen Cheng.
Nature Medicine (2016)

488 Citations

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

Lesley A. Mathews Griner;Rajarshi Guha;Paul Shinn;Ryan M. Young.
Proceedings of the National Academy of Sciences of the United States of America (2014)

365 Citations

A high-throughput screen for aggregation-based inhibition in a large compound library.

Brian Y. Feng;Anton Simeonov;Ajit Jadhav;Kerim Babaoglu.
Journal of Medicinal Chemistry (2007)

355 Citations

Gene expression analysis identifies global gene dosage sensitivity in cancer

Rudolf S. N. Fehrmann;Juha M. Karjalainen;Małgorzata Krajewska;Harm-Jan Westra.
Nature Genetics (2015)

325 Citations

Fluorescence Polarization Assays in Small Molecule Screening

Wendy A Lea;Anton Simeonov.
Expert Opinion on Drug Discovery (2011)

307 Citations

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

Ahmed A Sayed;Anton Simeonov;Craig J Thomas;James Inglese.
Nature Medicine (2008)

300 Citations

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