Anton Simeonov

Overview

Best Publications

• Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

  James Inglese;Douglas S. Auld;Ajit Jadhav;Ronald L. Johnson

  883
  Citations

• Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

  Richard T. Eastman;Jacob S. Roth;Jacob S. Roth;Kyle R. Brimacombe;Anton Simeonov

  861
  Citations

• Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

  Susanne A.I. Seidel;Patricia M. Dijkman;Wendy A. Lea;Geert van den Bogaart

  741
  Citations

• High-throughput screening assays for the identification of chemical probes

  James Inglese;Ronald L Johnson;Anton Simeonov;Menghang Xia

  727
  Citations

• Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

  Miao Xu;Emily M. Lee;Zhexing Wen;Yichen Cheng

  692
  Citations

• Fluorescence Polarization Assays in Small Molecule Screening

  Wendy A Lea;Anton Simeonov

  432
  Citations

• High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

  Lesley A. Mathews Griner;Rajarshi Guha;Paul Shinn;Ryan M. Young

  427
  Citations

• A high-throughput screen for aggregation-based inhibition in a large compound library.

  Brian Y. Feng;Anton Simeonov;Ajit Jadhav;Kerim Babaoglu

  408
  Citations

• Unexplored therapeutic opportunities in the human genome.

  Tudor I. Oprea;Cristian G. Bologa;Søren Brunak;Allen Campbell

  406
  Citations

• Gene expression analysis identifies global gene dosage sensitivity in cancer

  Rudolf S. N. Fehrmann;Juha M. Karjalainen;Małgorzata Krajewska;Harm-Jan Westra

  387
  Citations

• Identification of oxadiazoles as new drug leads for the control of schistosomiasis

  Ahmed A Sayed;Anton Simeonov;Craig J Thomas;James Inglese

  312
  Citations

• Pharos: Collating protein information to shed light on the druggable genome

  Dac-Trung Nguyen;Stephen L. Mathias;Cristian Bologa;Søren Brunak

  307
  Citations

• A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

  Lei Wang;Jianjun Chang;Diana Varghese;Michael T Dellinger

  300
  Citations

• The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics.

  Ruili Huang;Ivan Grishagin;Yuhong Wang;Tongan Zhao

  299
  Citations

• A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

  Qin Liang;Thomas S Dexheimer;Ping Zhang;Andrew S Rosenthal

  282
  Citations

• Fluorescence Spectroscopic Profiling of Compound Libraries

  Anton Simeonov;Ajit Jadhav;Craig J. Thomas;Yuhong Wang

  281
  Citations

• Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

  Jesse M. Jaynes;Rushikesh Sable;Michael Ronzetti;Wendy Bautista

  280
  Citations

• Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.

  Rafaela S. Ferreira;Anton Simeonov;Ajit Jadhav;Oliv Eidam

  266
  Citations

• Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease

  Ajit Jadhav;Rafaela S. Ferreira;Carleen Klumpp;Bryan T. Mott

  263
  Citations

• Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

  Feng Liu;Xin Chen;Abdellah Allali-Hassani;Amy M. Quinn

  244
  Citations