His scientific interests lie mostly in Biochemistry, Cancer research, Methyltransferase, Signal transduction and Histone H3. His Cancer research research includes themes of Haematopoiesis, Leukemia, Immunology, Kinase and Genomic imprinting. His research investigates the connection between Methyltransferase and topics such as Transferase that intersect with issues in Arginine and Chromatin remodeling.
His Signal transduction study which covers Receptor that intersects with Neuroscience and Optogenetics. Jian Jin combines subjects such as EZH2 and Gene knockdown with his study of Histone H3. Jian Jin has included themes like Stereochemistry and Small molecule in his Structure–activity relationship study.
Jian Jin focuses on Biochemistry, Cancer research, Methyltransferase, Epigenetics and Pharmacology. His study in Structure–activity relationship, Lysine, Small molecule, Enzyme and Drug discovery is carried out as part of his studies in Biochemistry. Jian Jin focuses mostly in the field of Cancer research, narrowing it down to matters related to EZH2 and, in some cases, Multiple myeloma and Histone H3.
The various areas that Jian Jin examines in his Methyltransferase study include Arginine, Stereochemistry and Transferase. His Epigenetics research is multidisciplinary, incorporating perspectives in Histone, Cellular differentiation and Cell biology. His Pharmacology study integrates concerns from other disciplines, such as Agonist, Receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor and In vivo.
Jian Jin spends much of his time researching Cancer research, Cell biology, Epigenetics, Methylation and Methyltransferase. His work deals with themes such as Cancer, Cell culture, EZH2, Cyclin-dependent kinase 6 and Multiple myeloma, which intersect with Cancer research. His Cell biology research also works with subjects such as
He interconnects Wnt signaling pathway, Epigenomics, Downregulation and upregulation and Cellular differentiation in the investigation of issues within Epigenetics. His research integrates issues of RNA Splicing Factors, RNA splicing, Histone and Leukemia in his study of Methylation. Biochemistry and DNA are closely tied to his Methyltransferase research.
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
James S. Duncan;Martin C. Whittle;Kazuhiro Nakamura;Amy N. Abell.
The promise and peril of chemical probes.
Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell.
Nature Chemical Biology (2015)
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Masoud Vedadi;Dalia Barsyte-Lovejoy;Feng Liu;Sylvie Rival-Gervier.
Nature Chemical Biology (2011)
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.
Kyle D. Konze;Anqi Ma;Fengling Li;Dalia Barsyte-Lovejoy.
ACS Chemical Biology (2013)
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.
Hsien Sung Huang;John A. Allen;Angela M. Mabb;Ian F. King.
Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy
John A. Allen;Julianne M. Yost;Vincent Setola;Xin Chen.
Proceedings of the National Academy of Sciences of the United States of America (2011)
Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains
Timothy J. Stuhlmiller;Samantha M. Miller;Jon S. Zawistowski;Kazuhiro Nakamura.
Cell Reports (2015)
First chelated chiral N-heterocyclic bis-carbene complexes
Dean S. Clyne;Jian Jin;Evan Genest;and Judith C. Gallucci.
Organic Letters (2000)
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
Feng Liu;Xin Chen;Abdellah Allali-Hassani;Amy M. Quinn.
Journal of Medicinal Chemistry (2009)
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
Feng Liu;Dalia Barsyte-Lovejoy;Fengling Li;Yan Xiong.
Journal of Medicinal Chemistry (2013)
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