World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
21215
World Ranking
4782
National Ranking
2313

Overview

Jian Jin is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with significant contributions to medicine as well.

Their work extensively covers molecular biology, oncology, hematology, cellular and molecular neuroscience, and genetics as key subfields of study.

Major topics explored by Jian Jin include protein degradation and inhibitors, ubiquitin and proteasome pathways, epigenetics and DNA methylation, cancer-related gene regulation, peptidase inhibition and analysis, RNA modifications and cancer, and histone deacetylase inhibitors research.

Jian Jin has published research in various prominent venues, with frequent publications in:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Journal of the American Chemical Society
  • Cancer Research

Notable recent papers include:

  • Advancing targeted protein degradation for cancer therapy, 2021, Nature Reviews Cancer
  • Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys, 2020, Nature Neuroscience
  • Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions, 2020, Medicinal Research Reviews
  • Light-induced control of protein destruction by opto-PROTAC, 2020, Science Advances
  • Pharmacologic modulation of RNA splicing enhances anti-tumor immunity, 2021, Cell

Jian Jin has collaborated frequently with fellow researchers including H. Ümit Kanıskan, Xufen Yu, Yan Xiong, Xian Chen, and Kwang-Su Park.

Best Publications

  • The promise and peril of chemical probes.

    Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell

  • Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

    James S. Duncan;Martin C. Whittle;Kazuhiro Nakamura;Amy N. Abell

  • A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

    Masoud Vedadi;Dalia Barsyte-Lovejoy;Feng Liu;Sylvie Rival-Gervier

  • An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

    Kyle D. Konze;Anqi Ma;Fengling Li;Dalia Barsyte-Lovejoy

  • Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.

    Hsien Sung Huang;John A. Allen;Angela M. Mabb;Ian F. King

  • Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.

    Yuji Nagai;Naohisa Miyakawa;Hiroyuki Takuwa;Yukiko Hori

  • Advancing targeted protein degradation for cancer therapy.

    Brandon Dale;Meng Cheng;Kwang-Su Park;H. Ümit Kaniskan

  • Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

    John A. Allen;Julianne M. Yost;Vincent Setola;Xin Chen

  • Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains

    Timothy J. Stuhlmiller;Samantha M. Miller;Jon S. Zawistowski;Kazuhiro Nakamura

  • In silico design of novel probes for the atypical opioid receptor MRGPRX2

    Katherine Lansu;Joel Karpiak;Jing Liu;Xi Ping Huang

  • Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

    Xi Ping Huang;Joel Karpiak;Wesley K. Kroeze;Hu Zhu

  • Inhibitors of Protein Methyltransferases and Demethylases.

    H. Ümit Kaniskan;Michael L. Martini;Jian Jin

  • Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

    Feng Liu;Dalia Barsyte-Lovejoy;Fengling Li;Yan Xiong

  • Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

    Bret D. Wallace;Adam B. Roberts;Rebecca M. Pollet;James D. Ingle

  • A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

    Mohammad S. Eram;Yudao Shen;Magdalena M. Szewczyk;Hong Wu

  • Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

    Feng Liu;Xin Chen;Abdellah Allali-Hassani;Amy M. Quinn

  • Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions

    Sezen Vatansever;Avner Schlessinger;Daniel Wacker;H Ümit Kaniskan

  • Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

    Bowen Xu;Doan M. On;Anqi Ma;Trevor Parton

  • Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

    Jia Yi Fong;Jia Yi Fong;Luca Pignata;Luca Pignata;Pierre-Alexis Goy;Pierre-Alexis Goy;Kimihito Cojin Kawabata

  • Light-induced control of protein destruction by opto-PROTAC.

    Jing Liu;He Chen;Leina Ma;Zhixiang He

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Masoud Vedadi
Masoud Vedadi Structural Genomics Consortium
Peter Brown
Peter Brown University of Oxford
Stephen V. Frye
Stephen V. Frye University of North Carolina at Chapel Hill
Bryan L. Roth
Bryan L. Roth University of North Carolina at Chapel Hill
Matthieu Schapira
Matthieu Schapira University of Toronto
Dalia Barsyte-Lovejoy
Dalia Barsyte-Lovejoy Structural Genomics Consortium
Xi Ping Huang
Xi Ping Huang University of North Carolina at Chapel Hill
Henry M. Sarau
Henry M. Sarau GlaxoSmithKline (United Kingdom)
T. V. RajanBabu
T. V. RajanBabu The Ohio State University

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