David A. Fruman

Research.com Recognitions

• 2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• The PI3K pathway in human disease

  David A. Fruman;Honyin Chiu;Benjamin D. Hopkins;Shubha Bagrodia

  2141
  Citations

• PI3K and cancer: lessons, challenges and opportunities

  David A. Fruman;Christian Rommel

  1770
  Citations

• Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

  David A. Fruman;Claude B. Klee;Barbara E. Bierer;Steven J. Burakoff

  1035
  Citations

• Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

  David A. Fruman;Scott B. Snapper;Claudine M. Yballe;Laurie Davidson

  813
  Citations

• Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.

  Hwai Wen Chang;Masahiro Aoki;David Fruman;Kurt R. Auger

  540
  Citations

• Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

  Andrew M. Scharenberg;Ousama El-Hillal;David A. Fruman;Laurie O. Beitz

  536
  Citations

• Phosphoinositide 3-Kinase: Diverse Roles in Immune Cell Activation

  Jonathan A. Deane;David A. Fruman

  468
  Citations

• Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

  Matthew R Janes;Jose J Limon;Lomon So;Jing Chen

  458
  Citations

• Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha.

  D.A. Fruman;F. Mauvais-Jarvis;D.A. Pollard;C.M. Yballe

  374
  Citations

• Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

  Kohjiro Ueki;David A. Fruman;David A. Fruman;Saskia M. Brachmann;Saskia M. Brachmann;Saskia M. Brachmann;Yu-Hua Tseng

  366
  Citations

• Immunophilins in protein folding and immunosuppression.

  David A. Fruman;Steven J. Burakoff;Barbara E. Bierer

  338
  Citations

• Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

  Franck Mauvais-Jarvis;Kohjiro Ueki;David A. Fruman;Michael F. Hirshman

  338
  Citations

• Xid-like phenotypes: a B cell signalosome takes shape.

  David A Fruman;Anne B Satterthwaite;Owen N Witte

  316
  Citations

• Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling *

  Kohjiro Ueki;David A. Fruman;Claudine M. Yballe;Mathias Fasshauer

  296
  Citations

• Phosphoinositide 3-kinase in immunological systems

  David A Fruman;Lewis C Cantley

  288
  Citations

• PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances

  Lomon So;David A. Fruman

  287
  Citations

• Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology

  Barbara E. Bierer;Georg Holländer;David Fruman;Steven J. Burakoff

  263
  Citations

• Fine tuning the immune response with PI3K

  David A. Fruman;Georges Bismuth

  253
  Citations

• Regulation of quiescence in lymphocytes

  Isharat Yusuf;David A. Fruman

  253
  Citations

• SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling

  Laurie O. Beitz;David A. Fruman;David A. Fruman;Tomohiro Kurosaki;Lewis C. Cantley;Lewis C. Cantley

  242
  Citations