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Biology and Biochemistry

D-Index
74
Citations
26087
World Ranking
5485
National Ranking
422

Overview

Klaus Okkenhaug is affiliated with the University of Cambridge in the United Kingdom. Their research career centers primarily on immunology and microbiology, with significant contributions also made in the fields of medicine, molecular biology, oncology, genetics, and epidemiology.

Their most recent published papers include:

  • PI3K inhibitors are finally coming of age, 2021, Nature Reviews Drug Discovery
  • Tumors induce de novo steroid biosynthesis in T cells to evade immunity, 2020, Nature Communications
  • CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function, 2021, Immunology
  • Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate, 2020, Nature Communications
  • Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs, 2022, Nature

Okkenhaug's frequent co-authors include:

  • Rahul Roychoudhuri
  • Charlotte J. Imianowski
  • Sarah K. Whiteside
  • Paula Kuo
  • Anita Chandra

The main publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Frontiers in Immunology
  • Nature Reviews Drug Discovery
  • Nature

Research topics covered in their publications embrace the following areas:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Immune cells in cancer
  • Chronic Lymphocytic Leukemia Research
  • Cancer Immunotherapy and Biomarkers

Okkenhaug's body of work demonstrates a focus on understanding immune cell mechanisms and interactions, with particular emphasis on T-cell and B-cell immunology as well as their roles in cancer and immunotherapy. Their research includes exploration of targeted therapies such as PI3K inhibitors and investigations into immune evasion by tumors.

Best Publications

  • Requirement of bic/microRNA-155 for normal immune function.

    Antony Rodriguez;Elena Vigorito;Simon Clare;Madhuri V. Warren;Madhuri V. Warren

  • Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer

    Roy Katso;Klaus Okkenhaug;Khatereh Ahmadi;Sarah White

  • Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

    Colin Selman;Jennifer M A Tullet;Daniela Wieser;Elaine Elizabeth Irvine

  • Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

    Klaus Okkenhaug;Antonio Bilancio;Géraldine Farjot;Helen Priddle

  • PI3K in lymphocyte development, differentiation and activation

    Klaus Okkenhaug;Bart Vanhaesebroeck

  • Ionic immune suppression within the tumour microenvironment limits T cell effector function

    Robert Eil;Suman K. Vodnala;David Clever;Christopher A. Klebanoff;Christopher A. Klebanoff

  • Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

    Ivan Angulo;Oscar Vadas;Fabien Garçon;Edward Banham-Hall

  • Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

    Colin Selman;Steven Lingard;Agharul I. Choudhury;Rachel L. Batterham

  • PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

    David K. Finlay;Ella Rosenzweig;Linda V. Sinclair;Carmen Feijoo-Carnero

  • Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

    Khaled Ali;Dalya R. Soond;Roberto Piñeiro;Thorsten Hagemann

  • Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

    Lazaros C. Foukas;Marc Claret;Wayne Pearce;Klaus Okkenhaug;Klaus Okkenhaug

  • Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

    Khaled Ali;Antonio Bilancio;Matthew Thomas;Wayne Pearce

  • Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

    Klaus Okkenhaug

  • Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

    Tanya I Coulter;Anita Chandra;Chris M Bacon;Judith Babar

  • Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells

    Susan Kohlhaas;Oliver A. Garden;Cheryl Scudamore;Martin Turner

  • Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.

    Linda V Sinclair;David Finlay;Carmen Feijoo;Georgina H Cornish

  • The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ

    Julie Guillermet-Guibert;Katja Bjorklof;Katja Bjorklof;Ashreena Salpekar;Ashreena Salpekar;Cristiano Gonella;Cristiano Gonella

  • Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

    Alison M. Condliffe;Keith Davidson;Karen E. Anderson;Chris D. Ellson

  • Cutting edge: The phosphoinositide 3-kinase p110 delta is critical for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells

    Daniel T. Patton;Oliver A. Garden;Oliver A. Garden;Wayne P. Pearce;Louise E. Clough

  • Multi-tissue DNA methylation age predictor in mouse

    Thomas M. Stubbs;Marc Jan Bonder;Anne-Katrien Stark;Felix Krueger

Frequent Co-Authors

Bart Vanhaesebroeck
Bart Vanhaesebroeck University College London
Martin R. Turner
Martin R. Turner University of Oxford
Federica M. Marelli-Berg
Federica M. Marelli-Berg Queen Mary University of London
Robert Rottapel
Robert Rottapel University of Toronto
Edwin R. Chilvers
Edwin R. Chilvers Imperial College London
Menna R. Clatworthy
Menna R. Clatworthy University of Cambridge
Phillip T. Hawkins
Phillip T. Hawkins Babraham Institute
Claudia Kemper
Claudia Kemper National Institutes of Health
Len R. Stephens
Len R. Stephens Babraham Institute
Capucine Picard
Capucine Picard Université Paris Cité

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