Len R. Stephens

Overview

Best Publications

• Structural Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

  Edward H. Walker;Michael E. Pacold;Olga Perisic;Len Stephens

  1471
  Citations

• Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

  Len Stephens;Karen Anderson;David Stokoe;Hediye Erdjument-Bromage

  1421
  Citations

• PI3K signalling: the path to discovery and understanding

  Bart Vanhaesebroeck;Len Stephens;Phillip Hawkins

  1051
  Citations

• A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

  L. Stephens;A. Smrcka;F. T. Cooke;T. R. Jackson

  791
  Citations

• Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

  Michael E. Pacold;Sabine Suire;Olga Perisic;Samuel Lara-Gonzalez

  773
  Citations

• P-rex1, a ptdins (3, 4, 5) p3- g-beta-gamma-regulated guanine-nucleotide exchange factor for rac

  Len Stephens;Phillip Thomas Hawkins

  738
  Citations

• The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

  L.R Stephens;A Eguinoa;H Erdjument-Bromage;M Lui

  728
  Citations

• Signalling through Class I PI3Ks in mammalian cells

  P.T. Hawkins;K.E. Anderson;K. Davidson;L.R. Stephens

  720
  Citations

• PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

  Phillip T. Hawkins;Alicia Eguinoa;Rong-Guo Qiu;David Stokoe

  712
  Citations

• Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

  Ivan Angulo;Oscar Vadas;Fabien Garçon;Edward Banham-Hall

  680
  Citations

• Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: A new intracellular signalling system?

  L.R. Stephens;T.R. Jackson;P.T. Hawkins

  630
  Citations

• Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils.

  L. R. Stephens;K. T. Hughes;R. F. Irvine

  627
  Citations

• Structural insights into phosphoinositide 3-kinase catalysis and signalling.

  Edward H. Walker;Olga Perisic;Christian Ried;Len Stephens

  615
  Citations

• Activation of the small GTP-binding proteins rho and rac by growth factor receptors.

  C.D. Nobes;P. Hawkins;L. Stephens;A. Hall

  597
  Citations

• Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

  Stefan Wennström;Phillip Hawkins;Frank Cooke;Kenta Hara

  560
  Citations

• 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

  K Hara;K Yonezawa;H Sakaue;A Ando

  546
  Citations

• PI3K signalling in inflammation.

  P.T. Hawkins;L.R. Stephens

  525
  Citations

• Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

  Karen E. Anderson;John Coadwell;Len R. Stephens;Phillip T. Hawkins

  504
  Citations

• PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox).

  Chris D. Ellson;Stéphanie Gobert-Gosse;Stéphanie Gobert-Gosse;Karen E Anderson;Keith Davidson

  476
  Citations

• Phosphoinositide 3-kinase-dependent activation of Rac

  Heidi C.E. Welch;W.John Coadwell;Len R. Stephens;Phillip T. Hawkins

  442
  Citations