2026 Mauno Vihinen: Genetics Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Genetics	76	1831	1741	19	19	318	20525

Overview

Mauno Vihinen is affiliated with Lund University in Sweden and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine. Their research has focused on subfields such as Molecular Biology, Genetics, Neurology, Infectious Diseases, and Immunology.

Their recent scholarly work includes publications in various notable journals. Selected papers include:

"Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance" (2022, Blood Advances)
"BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib" (2021, Leukemia)
"TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration" (2021, Cell Reports)
"Structure-Function Relationships of Covalent and Non-Covalent BTK Inhibitors" (2021, Frontiers in Immunology)
"Functional effects of protein variants" (2020, Biochimie)

Frequent co-authors collaborating with Vihinen include:

Rula Zain
Yang Yang
Qing Wang
Ekaterina Savchenko
Yuriy Pomeshchik

The scientist's publications appear regularly in peer-reviewed venues such as:

International Journal of Molecular Sciences
F1000Research
Genes
bioRxiv (Cold Spring Harbor Laboratory)
The Journal of Heart and Lung Transplantation

The main research topics addressed by Vihinen focus on:

Genomics and Rare Diseases
RNA and protein synthesis mechanisms
Genomics and Phylogenetic Studies
Chronic Lymphocytic Leukemia Research
Protein Structure and Dynamics
Gene Regulatory Network Analysis
RNA modifications and cancer

Best Publications

The EUROclass trial: defining subgroups in common variable immunodeficiency

Claudia Wehr;Teemu Kivioja;Christian Schmitt;Berne Ferry

979
Citations
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

Wennuan Liu;Sari Laitinen;Sofia Khan;Mauno Vihinen

751
Citations
Performance of mutation pathogenicity prediction methods on missense variants.

Janita Thusberg;Ayodeji Olatubosun;Mauno Vihinen

634
Citations
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.

Abdalla J. Mohamed;Liang Yu;Carl-Magnus Bäckesjö;Leonardo Vargas

628
Citations
MICROBIAL AMYLOLYTIC ENZYMES

Mauno Vihinen;P Mantsala

600
Citations
V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations.

Anna Villa;Cristina Sobacchi;Luigi D. Notarangelo;Fabio Bozzi

406
Citations
The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

C I E Smith;T C Islam;Pekka T Mattsson;Pekka T Mattsson;A J Mohamed

396
Citations
Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family

Ulla Aapola;Kazunori Shibuya;Hamish S. Scott;Juha Ollila

391
Citations
Accuracy of protein flexibility predictions.

Mauno Vihinen;Mauno Vihinen;Esa Torkkila;Pentti Riikonen

390
Citations
Relationship of protein flexibility to thermostability

Mauno Vihinen

386
Citations
Performance of protein stability predictors.

Sofia Khan;Mauno Vihinen

346
Citations
How to evaluate performance of prediction methods? Measures and their interpretation in variation effect analysis

Mauno Vihinen;Mauno Vihinen

319
Citations
Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family

Jonna Lehtonen;Bairong Shen;Mauno Vihinen;Angela Casini

303
Citations
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.

Pipsa Saharinen;Mauno Vihinen;Olli Silvennoinen

296
Citations
The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein.

Jukka Pitkänen;Vassilis Doucas;Thomas Sternsdorf;Toshihiro Nakajima

286
Citations
Pathogenic or not? And if so, then how? Studying the effects of missense mutations using bioinformatics methods.

Janita Thusberg;Mauno Vihinen

279
Citations
Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.

Jessica M Lindvall;K Emelie M Blomberg;Jouni Väliaho;Leonardo Vargas

263
Citations
The mutational spectrum of human malignant autosomal recessive osteopetrosis

Cristina Sobacchi;Annalisa Frattini;Paul J Orchard;Oscar Porras

254
Citations
BTKbase: the mutation database for X-linked agammaglobulinemia

Jouni Väliaho;C.I. Edvard Smith;Mauno Vihinen

231
Citations
Finding Our Way through Phenotypes.

Andrew R. Deans;Suzanna E. Lewis;Eva Huala;Salvatore S. Anzaldo

229
Citations

Frequent Co-Authors

C. I. E. Smith Karolinska Institute

C. I. Edvard Smith Karolinska University Hospital

Hans D. Ochs University of Washington

George P. Patrinos University of Patras

Arleen D. Auerbach Rockefeller University

Silvia Giliani University of Brescia

Tapio Salakoski University of Turku

Lennart Nilsson Karolinska Institute

Anna Villa National Academies of Sciences, Engineering, and Medicine

Johan T. den Dunnen Leiden University Medical Center

External Links

Personal website of Mauno Vihinen

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