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D-Index & Metrics

Molecular Biology

D-Index
59
Citations
12701
World Ranking
2020
National Ranking
1005

Overview

Ryszard Kole is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research encompasses a range of fields primarily within biochemistry, genetics, molecular biology, and medicine. The scientist has contributed to multiple subfields including molecular biology, pulmonary and respiratory medicine, genetics, infectious diseases, and surgery.

Their scholarly output includes publications in various peer-reviewed journals and institutional repositories. Frequent publication venues include:

  • UNC Libraries
  • Nature Medicine
  • Nucleic Acids Research
  • Human Gene Therapy
  • The Journal of Infectious Diseases

Ryszard Kole's research topics mainly focus on RNA interference and gene delivery, RNA research and splicing, RNA modifications and cancer, DNA and nucleic acid chemistry, RNA and protein synthesis mechanisms, parvovirus B19 infection studies, and nuclear structure and function. These areas reflect a broad interest in nucleic acid biology and therapeutic applications.

Among their recent published papers are:

  • "A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome," 2021, Nature Medicine
  • "Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung," 2021, Nucleic Acids Research
  • "Engineered U7 Small Nuclear RNA Restores Correct β-Globin Pre-mRNA Splicing in Mouse β IVS2-654 -Thalassemic Erythroid Progenitor Cells," 2020, Human Gene Therapy
  • "The Importance of Bcl-x L in the Survival of Human RPE Cells," 2021, UNC Libraries
  • "Post-Pandemic Dynamics of the Global Circulation of Human Metapneumovirus and Respiratory Syncytial Virus," 2025, The Journal of Infectious Diseases

Ryszard Kole collaborates frequently with other researchers, including:

  • Peter Sazani
  • Hong M. Moulton
  • Natee Jearawiriyapaisarn
  • Jennifer Roberts
  • Yan L. Dang

Their work spans fundamental and applied research in molecular mechanisms underlying disease as well as therapeutic development, particularly focusing on RNA-targeted strategies.

Best Publications

  • RNA therapeutics: beyond RNA interference and antisense oligonucleotides

    Ryszard Kole;Adrian R. Krainer;Sidney Altman

  • Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides.

    Zbigniew Dominski;Ryszard Kole

  • Up-Regulation of Luciferase Gene Expression with Antisense Oligonucleotides: Implications and Applications in Functional Assay Development†

    Shin-Hong Kang;Moo-Jung Cho;Ryszard Kole

  • Repair of thalassemic human β-globin mRNA in mammalian cells by antisense oligonucleotides

    Halina Sierakowska;Maria J. Sambade;Sudhir Agrawal;Ryszard Kole

  • Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

    Natee Jearawiriyapaisarn;Hong M Moulton;Brian Buckley;Jennifer Roberts

  • Systemically delivered antisense oligomers upregulate gene expression in mouse tissues

    Peter Sazani;Federica Gemignani;Shin-Hong Kang;Martin A. Maier

  • Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides

    Stephen D Wilton;Frances Lloyd;Kylie Carville;Sue Fletcher

  • Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

    Peter Sazani;Ryszard Kole

  • Selection of splice sites in pre-mRNAs with short internal exons.

    Zbigniew Dominski;Ryszard Kole

  • Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs

    Peter Sazani;Shin-Hong Kang;Martin A. Maier;Changfu Wei

  • RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds

    Paul J. Furdon;Zbigniew Dominski;Ryszard Kole

  • Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients.

    Giuseppina Lacerra;Halina Sierakowska;Clementina Carestia;Suthat Fucharoen

  • Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents

    Danielle R. Mercatante;James L. Mohler;Ryszard Kole

  • Correction of aberrant splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by antisense oligonucleotides.

    Kenneth J. Friedman;Jolanta Kole;Jonathan A. Cohn;Jonathan A. Cohn;Michael R. Knowles

  • Modification of Alternative Splicing of Bcl-x Pre-mRNA in Prostate and Breast Cancer Cells ANALYSIS OF APOPTOSIS AND CELL DEATH

    Danielle R. Mercatante;Carl D. Bortner;John A. Cidlowski;Ryszard Kole

  • Therapeutic potential of splice-switching oligonucleotides.

    John Bauman;Natee Jearawiriyapaisarn;Ryszard Kole

  • Stable alteration of pre-mRNA splicing patterns by modified U7 small nuclear RNAs.

    Linda Gorman;Daniel Suter;Victoria Emerick;Daniel Schümperli

  • Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides.

    Rudolph L Juliano;S. Alahari;H. Yoo;R. Kole

  • Antisense oligonucleotide inhibiting aberrant splicing and method of using the same

    Ryszard Kole;コール,リスザード;Zbigniew Dominski;ドミンスキー,ズビグニエフ

  • E. coli RNAase P has a required RNA component in vivo

    Ryszard Kole;Madeline F. Baer;Benjamin C. Stark;Sidney Altman

Frequent Co-Authors

Suthat Fucharoen
Suthat Fucharoen Mahidol University
Daniel Schümperli
Daniel Schümperli University of Bern
Sue Fletcher
Sue Fletcher Murdoch University
Steve D. Wilton
Steve D. Wilton University of Western Australia
Sudhir Agrawal
Sudhir Agrawal University of Massachusetts Chan Medical School
Muthiah Manoharan
Muthiah Manoharan Alnylam Pharmaceuticals (United States)
Martin Maier
Martin Maier Alnylam Pharmaceuticals (United States)
Patrick L. Iversen
Patrick L. Iversen Oregon State University
Jonathan A. Cohn
Jonathan A. Cohn Duke University
Nobuyo Maeda
Nobuyo Maeda University of North Carolina at Chapel Hill

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