Ryszard Kole mostly deals with Molecular biology, RNA splicing, Oligonucleotide, Alternative splicing and Intron. The Molecular biology study combines topics in areas such as Mutation, Morpholino and Exon. Ryszard Kole works in the field of RNA splicing, focusing on Splice site mutation in particular.
His studies deal with areas such as Gel electrophoresis, Nucleic acid thermodynamics, Messenger RNA and Phosphodiester bond as well as Oligonucleotide. His work focuses on many connections between Alternative splicing and other disciplines, such as Transfection, that overlap with his field of interest in Apoptosis. His study in Intron is interdisciplinary in nature, drawing from both Gene expression and splice.
Ryszard Kole focuses on RNA splicing, Molecular biology, Oligonucleotide, Intron and Gene. His work deals with themes such as splice and Messenger RNA, Alternative splicing, Exon, which intersect with RNA splicing. His Alternative splicing research is multidisciplinary, incorporating perspectives in Apoptosis, Cancer research and Cancer.
His study looks at the relationship between Exon and topics such as Precursor mRNA, which overlap with Ribonucleoprotein. Ryszard Kole interconnects Morpholino, Mutation, Transfection, HeLa and Globin in the investigation of issues within Molecular biology. The concepts of his Oligonucleotide study are interwoven with issues in In vivo, Nucleic acid, Gene expression and RNase H.
His primary scientific interests are in RNA splicing, Molecular biology, Morpholino, Cell biology and Exon skipping. His RNA splicing study necessitates a more in-depth grasp of Gene. Ryszard Kole has researched Molecular biology in several fields, including Oligonucleotide, DNA and Exon.
His work carried out in the field of Morpholino brings together such families of science as Deficient mouse, Pharmacology and Utrophin. His Exon skipping research includes themes of Muscular dystrophy, Duchenne muscular dystrophy and Dystrophin. His Messenger RNA research incorporates elements of Mutation and Intron.
His primary areas of investigation include Molecular biology, Morpholino, Muscular dystrophy, Duchenne muscular dystrophy and Exon skipping. His Molecular biology research incorporates themes from Thalassemia, Cardiac muscle, Mutation, Messenger RNA and splice. His studies in Morpholino integrate themes in fields like mdx mouse, RNA splicing, Intron and Exon.
The study incorporates disciplines such as Regulator, Cancer, Cancer research and Downregulation and upregulation in addition to RNA splicing. In general Muscular dystrophy, his work in Dystrophin is often linked to Diastole linking many areas of study. His Duchenne muscular dystrophy research is multidisciplinary, incorporating elements of Endocrinology and Heart failure.
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Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides.
Zbigniew Dominski;Ryszard Kole.
Proceedings of the National Academy of Sciences of the United States of America (1993)
Systemically delivered antisense oligomers upregulate gene expression in mouse tissues
Peter Sazani;Federica Gemignani;Shin-Hong Kang;Martin A. Maier.
Nature Biotechnology (2002)
Up-Regulation of Luciferase Gene Expression with Antisense Oligonucleotides: Implications and Applications in Functional Assay Development†
Shin-Hong Kang;Moo-Jung Cho;Ryszard Kole.
Repair of thalassemic human β-globin mRNA in mammalian cells by antisense oligonucleotides
Halina Sierakowska;Maria J. Sambade;Sudhir Agrawal;Ryszard Kole.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.
Natee Jearawiriyapaisarn;Hong M Moulton;Brian Buckley;Jennifer Roberts.
Molecular Therapy (2008)
Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
Peter Sazani;Ryszard Kole.
Journal of Clinical Investigation (2003)
Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides
Stephen D Wilton;Frances Lloyd;Kylie Carville;Sue Fletcher.
Neuromuscular Disorders (1999)
Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs
Peter Sazani;Shin-Hong Kang;Martin A. Maier;Changfu Wei.
Nucleic Acids Research (2001)
Selection of splice sites in pre-mRNAs with short internal exons.
Zbigniew Dominski;Ryszard Kole.
Molecular and Cellular Biology (1991)
Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients.
Giuseppina Lacerra;Halina Sierakowska;Clementina Carestia;Suthat Fucharoen.
Proceedings of the National Academy of Sciences of the United States of America (2000)
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