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Molecular Biology

D-Index
66
Citations
15138
World Ranking
1620
National Ranking
48

Overview

Benoit Chabot is affiliated with the Université de Sherbrooke in Canada. Their research spans biochemistry, genetics, and molecular biology, with significant contributions in medicine. Their work mainly focuses on molecular biology and genetics, with additional insights in epidemiology, plant science, and immunology.

Their research addresses key topics including:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Hepatitis B Virus Studies
  • Virus-based gene therapy research
  • HIV Research and Treatment
  • Chronic Lymphocytic Leukemia Research

Benoit Chabot has published extensively, with frequent contributions to venues such as bioRxiv (Cold Spring Harbor Laboratory), RNA, Viruses, Nature Communications, and PLoS Pathogens. Their notable recent papers include:

  • "The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma," 2022, Nature Communications
  • "SRSF10: an atypical splicing regulator with critical roles in stress response, organ development, and viral replication," 2021, RNA
  • "Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production," 2020, PLoS Pathogens
  • "NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay," 2020, Cell Reports
  • "Interplay Between CMGC Kinases Targeting SR Proteins and Viral Replication: Splicing and Beyond," 2021, Frontiers in Microbiology

The scientist collaborates regularly with several coauthors, including Lulzim Shkreta, David S. Grierson, Anna Salvetti, David Durantel, and Johanne Toutant. These collaborations contribute to a diverse research portfolio intersecting RNA biology and viral infections.

Best Publications

  • The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus.

    Benoit Chabot;Dennis A. Stephenson;Verne M. Chapman;Peter Besmer

  • U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

    Douglas L. Black;Benoit Chabot;Joan A. Steitz

  • Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

    K Nocka;S Majumder;B Chabot;P Ray

  • Systematic Analysis of the Protein Interaction Network for the Human Transcription Machinery Reveals the Identity of the 7SK Capping Enzyme

    Célia Jeronimo;Diane Forget;Annie Bouchard;Qintong Li

  • hnRNP proteins and splicing control.

    Rebeca Martinez-Contreras;Philippe Cloutier;Lulzim Shkreta;Jean-Francois Fisette

  • Cancer-associated regulation of alternative splicing.

    Julian P Venables;Roscoe Klinck;ChuShin Koh;Julien Gervais-Bird

  • A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

    A Lavigueur;H La Branche;A R Kornblihtt;B Chabot

  • Control of alternative splicing through siRNA-mediated transcriptional gene silencing.

    Mariano Alló;Valeria Buggiano;Juan P Fededa;Ezequiel Petrillo

  • Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase

    Hélène LaBranche;Sophie Dupuis;Yaacov Ben-David;Maria Rosa Bani

  • The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein.

    Benoit Chabot;Douglas L. Black;David M. LeMaster;Joan A. Steitz

  • Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing

    Rebeca Martinez-Contreras;Jean-François Fisette;Faiz-ul Hassan Nasim;Richard Madden

  • Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization

    Marco Blanchette;Benoit Chabot

  • Directing alternative splicing: cast and scenarios

    Benoit Chabot

  • Heterogeneous Nuclear Ribonucleoprotein F/H Proteins Modulate the Alternative Splicing of the Apoptotic Mediator Bcl-x *

    Daniel Garneau;Timothée Revil;Jean-François Fisette;Benoit Chabot

  • The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

    Xiaoming Yang;Maria Rosa Bani;Shi Jiang Lu;Sheldon Rowan

  • Identification of alternative splicing markers for breast cancer.

    Julian P. Venables;Roscoe Klinck;Anne Bramard;Lyna Inkel

  • Defective control of pre–messenger RNA splicing in human disease

    Benoit Chabot;Lulzim Shkreta

  • Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines.

    Caroline Patry;Louise Bouchard;Pascale Labrecque;Daniel Gendron

  • Multiple alternative splicing markers for ovarian cancer.

    Roscoe Klinck;Anne Bramard;Lyna Inkel;Geneviève Dufresne-Martin

  • Multiple and Specific mRNA Processing Targets for the Major Human hnRNP Proteins

    Julian P. Venables;Chu-Shin Koh;Ulrike Froehlich;Elvy Lapointe

Frequent Co-Authors

Raymund J. Wellinger
Raymund J. Wellinger Université de Sherbrooke
Jamal Tazi
Jamal Tazi University of Montpellier
Jacques Piette
Jacques Piette University of Liège
Michael J. Strong
Michael J. Strong University of Michigan–Ann Arbor
Alain Colige
Alain Colige University of Liège
Andrew J. Mouland
Andrew J. Mouland McGill University
Joan A. Steitz
Joan A. Steitz Yale University
Peter Besmer
Peter Besmer Memorial Sloan Kettering Cancer Center
Alan Bernstein
Alan Bernstein Canadian Institute for Advanced Research

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