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Molecular Biology

D-Index
63
Citations
19858
World Ranking
1783
National Ranking
143

Research.com Recognitions

  • 2016 - Member of Academia Europaea
  • 2011 - Fellow of the Royal Society of Edinburgh

Overview

Javier F. Cáceres is affiliated with the University of Edinburgh in the United Kingdom and specializes in Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Genetics, Cancer Research, Cell Biology, and Pulmonary and Respiratory Medicine.

Their research primarily addresses topics within RNA Research and Splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, RNA regulation and disease, Endoplasmic Reticulum Stress and Disease, Cancer-related molecular mechanisms research, and Acute Myeloid Leukemia Research.

Recent publications by Javier F. Cáceres include:

  • The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants (2020, Nature Communications)
  • Translation-coupled mRNA quality control mechanisms (2023, The EMBO Journal)
  • Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum (2020, Genes & Development)
  • Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function (2021, eLife)
  • RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer (2022, Nature Communications)

Javier F. Cáceres frequently collaborates with other researchers. Notable co-authors include:

  • Nele Hug
  • Dáša Longman
  • Magdalena M. Maslon
  • Stuart Aitken
  • Ana Rio-Machín

Their work appears in publication venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, eLife, The EMBO Journal, and Genes & Development.

Javier F. Cáceres has been recognized as a Member of Academia Europaea since 2016 and a Fellow of the Royal Society of Edinburgh since 2011.

Best Publications

  • The SR protein family of splicing factors: master regulators of gene expression.

    Jennifer C Long;Javier F Caceres

  • Cdk1 is sufficient to drive the mammalian cell cycle

    David Santamaría;Cédric Barrière;Cédric Barrière;Antonio Cerqueira;Sarah Hunt

  • Alternative splicing: multiple control mechanisms and involvement in human disease

    Javier F Cáceres;Alberto R Kornblihtt

  • Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors.

    Javier F. Cáceres;Stefan Stamm;David M. Helfman;Adrian R. Krainer

  • The dynamics of a pre-mRNA splicing factor in living cells.

    Tom Misteli;Javier F. Cáceres;David L. Spector

  • The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

    Sonia Guil;Javier F Cáceres

  • A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm

    Javier F. Cáceres;Gavin R. Screaton;Adrian R. Krainer

  • Role of the Modular Domains of SR Proteins in Subnuclear Localization and Alternative Splicing Specificity

    Javier F. Cáceres;Tom Misteli;Gavin R. Screaton;David L. Spector

  • Mechanism and regulation of the nonsense-mediated decay pathway

    Nele Hug;Dagmar Longman;Javier F. Caceres

  • Post-transcriptional control of miRNA biogenesis

    Gracjan Michlewski;Javier F. Cáceres

  • A novel role for shuttling SR proteins in mRNA translation

    Jeremy R. Sanford;Nicola K. Gray;Karsten Beckmann;Javier F. Cáceres

  • Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

    A Hanamura;J F Cáceres;A Mayeda;B R Franza

  • The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation.

    W van der Houven van Oordt;M T Diaz-Meco;J Lozano;A R Krainer

  • Posttranscriptional regulation of miRNAs harboring conserved terminal loops.

    Gracjan Michlewski;Sonia Guil;Colin A. Semple;Javier F. Cáceres

  • Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

    Akila Mayeda;Stephen H. Munroe;Javier F. Cáceres;Adrian R. Krainer

  • Coupling of Transcription with Alternative Splicing: RNA Pol II Promoters Modulate SF2/ASF and 9G8 Effects on an Exonic Splicing Enhancer

    Paula Cramer;Javier F Cáceres;Demián Cazalla;Sebastián Kadener

  • hnRNP A1 Relocalization to the Stress Granules Reflects a Role in the Stress Response

    Sonia Guil;Jennifer C. Long;Javier F. Cáceres

  • Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

    Gavin R. Screaton;Javier F. Cáceres;Akila Mayeda;Martyn V. Bell

  • Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo

    Tom Misteli;Javier F. Cáceres;Jade Q. Clement;Adrian R. Krainer

  • Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains.

    J F Cáceres;A R Krainer

Frequent Co-Authors

Adrian R. Krainer
Adrian R. Krainer Cold Spring Harbor Laboratory
Eduardo Eyras
Eduardo Eyras Pompeu Fabra University
Benjamin J. Blencowe
Benjamin J. Blencowe University of Toronto
Alberto R. Kornblihtt
Alberto R. Kornblihtt University of Buenos Aires
Akila Mayeda
Akila Mayeda Fujita Health University
Gavin R. Screaton
Gavin R. Screaton University of Oxford
David L. Spector
David L. Spector Cold Spring Harbor Laboratory
Oscar Llorca
Oscar Llorca Spanish National Research Council
Inderjeet Dokal
Inderjeet Dokal Queen Mary University of London
Jorge Moscat
Jorge Moscat Cornell University

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