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Biology and Biochemistry

D-Index
57
Citations
9138
World Ranking
14069
National Ranking
298

Overview

Oscar Llorca is affiliated with the Spanish National Research Council in Spain and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology. Their research focuses on molecular and cell biology, with a particular interest in topics such as RNA modifications and cancer, enzyme structure and function, heat shock proteins, RNA and protein synthesis mechanisms, RNA research and splicing, microtubule and mitosis dynamics, and amino acid enzymes and metabolism.

Llorca's work is frequently published in several scientific venues, reflecting a strong presence in both preprint and peer-reviewed journals. Notable venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Current Opinion in Structural Biology
  • Cell Reports
  • Nucleic Acids Research

Their recent papers cover a range of topics in structural biology and molecular mechanisms. Some key publications include:

  • "Type VII secretion systems: structure, functions and transport models," 2021, Nature Reviews Microbiology
  • "Structural basis of Focal Adhesion Kinase activation on lipid membranes," 2020, The EMBO Journal
  • "RUVBL1-RUVBL2 AAA-ATPase: a versatile scaffold for multiple complexes and functions," 2020, Current Opinion in Structural Biology
  • "Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase," 2020, Science Advances
  • "Long Noncoding RNA NIHCOLE Promotes Ligation Efficiency of DNA Double-Strand Breaks in Hepatocellular Carcinoma," 2021, Cancer Research

Llorca's frequent collaborators include Marina Serna, Andrés López-Perrote, Jasminka Boskovic, Carlos F. Rodríguez, and Rafael Fernández-Leiro. This network indicates active teamwork in multiple research projects and contributes to the multidisciplinary nature of their studies.

Their main fields of study encompass 79 publications in biochemistry, genetics, and molecular biology, with 56 specifically in molecular biology and 10 in cell biology, alongside some work in materials chemistry, biochemistry, and oncology. The breadth of research topics highlights a comprehensive engagement with structural and functional aspects of cellular and molecular processes.

Best Publications

  • Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

    Laura Spagnolo;Angel Rivera-Calzada;Laurence H. Pearl;Oscar Llorca

  • Eukaryotic type II chaperonin CCT interacts with actin through specific subunits.

    Oscar Llorca;Elizabeth A. McCormack;Gillian Hynes;Julie Grantham

  • Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine

    Jonathan P. Schuermann;Jianwen Jiang;Jorge Cuellar;Oscar Llorca

  • Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

    Rubén Martínez-Barricarte;Meike Heurich;Francisco Valdes-Cañedo;Eduardo Vazquez-Martul

  • Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations

    Oscar Llorca;Jaime Martín-Benito;Monica Ritco-Vonsovici;Julie Grantham

  • Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

    Holger Rehmann;Ernesto Arias-Palomo;Michael A. Hadders;Frank Schwede

  • C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

    Agustín Tortajada;Hugo Yébenes;Cynthia Abarrategui-Garrido;Jaouad Anter

  • The Antibacterial Cell Division Inhibitor PC190723 Is an FtsZ Polymer-stabilizing Agent That Induces Filament Assembly and Condensation

    José Manuel Andreu;Claudia Schaffner-Barbero;Sonia Huecas;Dulce Alonso

  • Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

    Michael A. Hadders;Doryen Bubeck;Pietro Roversi;Svetlana Hakobyan

  • The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin.

    Oscar Llorca;Jaime Martín-Benito;Julie Grantham;Monica Ritco-Vonsovici

  • Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle.

    Jaime Martín‐Benito;Estela Area;Joaquín Ortega;Oscar Llorca

  • Energetics and Geometry of FtsZ Polymers : Nucleated Self-Assembly of Single Protofilaments

    Sonia Huecas;Oscar Llorca;Jasminka Boskovic;Jaime Martín-Benito

  • Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs.

    Angel Rivera-Calzada;Laura Spagnolo;Laurence H Pearl;Oscar Llorca

  • Structural Model of Human Endoglin, a Transmembrane Receptor Responsible for Hereditary Hemorrhagic Telangiectasia

    Oscar Llorca;Arturo Trujillo;Francisco J. Blanco;Carmelo Bernabeu

  • 3D reconstruction of the ATP-bound form of CCT reveals the asymmetric folding conformation of a type II chaperonin.

    Oscar Llorca;Martin G. Smyth;José L. Carrascosa;Keith R. Willison

  • Three-Dimensional Structure and Regulation of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs)

    Angel Rivera-Calzada;Joseph P. Maman;Laura Spagnolo;Laurence H. Pearl

  • Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

    Shuo Chen;Doryen Bubeck;Bryan T. MacDonald;Wen-Xue Liang

  • 3D architecture of DNA Pol α reveals the functional core of multi‐subunit replicative polymerases

    Sebastian Klinge;Rafael Núñez-Ramírez;Oscar Llorca;Luca Pellegrini

  • The formation of symmetrical GroEL-GroES complexes in the presence of ATP

    Oscar Llorca;Sergio Marco;José L. Carrascosa;José M. Valpuesta

  • Structure of TOR and Its Complex with KOG1

    Alessandra Adami;Begoña García-Álvarez;Ernesto Arias-Palomo;David Barford

Frequent Co-Authors

José M. Valpuesta
José M. Valpuesta Spanish National Research Council
José L. Carrascosa
José L. Carrascosa Spanish National Research Council
Laurence H. Pearl
Laurence H. Pearl University of Sussex
Santiago Rodríguez de Córdoba
Santiago Rodríguez de Córdoba Spanish National Research Council
Keith R. Willison
Keith R. Willison Imperial College London
Claire L. Harris
Claire L. Harris Newcastle University
B. Paul Morgan
B. Paul Morgan Cardiff University
Chrisostomos Prodromou
Chrisostomos Prodromou University of Sussex
Javier F. Cáceres
Javier F. Cáceres University of Edinburgh
Xosé R. Bustelo
Xosé R. Bustelo University of Salamanca

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