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Microbiology

D-Index
61
Citations
11511
World Ranking
3032
National Ranking
270

Overview

Claire L. Harris is affiliated with Newcastle University in the United Kingdom. Their research focuses primarily on medicine and immunology and microbiology, with 42 and 27 publications in these fields respectively. Subfields of study include immunology, ophthalmology, molecular biology, radiology, nuclear medicine and imaging, and hematology.

The main topics covered by Claire L. Harris's work include the complement system in diseases, retinal diseases and treatments, retinal development and disorders, renal diseases and glomerulopathies, mosquito-borne diseases and control, retinal imaging and analysis, and blood coagulation and thrombosis mechanisms.

Recent papers by Claire L. Harris demonstrate a focus on genetic and immunological mechanisms in various diseases:

  • Large-Scale Whole-Genome Sequencing Reveals the Genetic Architecture of Primary Membranoproliferative GN and C3 Glomerulopathy, 2020, Journal of the American Society of Nephrology
  • Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function, 2020, Stem Cells Translational Medicine
  • Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration, 2020, Investigative Ophthalmology & Visual Science
  • Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy, 2020, Kidney International
  • Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19, 2022, Immunology

Frequent coauthors with whom Claire L. Harris has collaborated include:

  • David Kavanagh (12 collaborations)
  • Kevin J. Marchbank (11 collaborations)
  • Thomas M Hallam (10 collaborations)
  • David Steel (8 collaborations)
  • Andrew Lotery (6 collaborations)

The venues where Claire L. Harris most often publishes include:

  • Frontiers in Immunology (3 publications)
  • Immunobiology (3 publications)
  • Journal of the American Society of Nephrology (2 publications)
  • Immunological Reviews (2 publications)
  • Human Molecular Genetics (2 publications)

In addition to journal articles, Claire L. Harris has contributed to book publications released by the European Organization for Nuclear Research, including the 2023 booklet titled "Partnering for Success - 2023 ARDC Impact Booklet."

Best Publications

  • C3 glomerulopathy: consensus report

    Matthew C. Pickering;Vivette D. D'agati;Carla M. Nester;Richard J. Smith

  • Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.

    Elena Goicoechea de Jorge;Claire L. Harris;Jorge Esparza-Gordillo;Luis Carreras

  • Complement, a target for therapy in inflammatory and degenerative diseases.

    B. Paul Morgan;Claire L. Harris;Claire L. Harris

  • Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59.

    Aled Clayton;Claire L. Harris;Jacquelyn Court;Malcolm D. Mason

  • Dimerization of complement factor H-related proteins modulates complement activation in vivo

    E. Goicoechea de Jorge;J. J. E. Caesar;T. H. Malik;M. Patel

  • Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

    Rubén Martínez-Barricarte;Meike Heurich;Francisco Valdes-Cañedo;Eduardo Vazquez-Martul

  • Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk

    Meike Heurich;Ruben Martínez-Barricarte;Nigel J. Francis;Dawn L. Roberts

  • Complement: central to innate immunity and bridging to adaptive responses.

    B. Paul Morgan;Kevin J. Marchbank;M. Paula Longhi;Claire L. Harris

  • Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

    Mark S. Cragg;Claire Harris;Claire Harris;Andreas Strasser;Clare L. Scott;Clare L. Scott

  • Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

    Mark S. Cragg;Elisa S. Jansen;Michele Cook;Claire Harris

  • Complement therapeutics; history and current progress

    B Paul Morgan;Claire L Harris

  • C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

    Agustín Tortajada;Hugo Yébenes;Cynthia Abarrategui-Garrido;Jaouad Anter

  • CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells.

    Kristina Elward;Mark Griffiths;Masashi Mizuno;Claire L. Harris

  • PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER

    Yusuke Maeda;Yusuke Maeda;Reika Watanabe;Reika Watanabe;Claire L. Harris;Yeongjin Hong

  • The complotype: dictating risk for inflammation and infection

    Claire L. Harris;Meike Heurich;Santiago Rodriguez de Cordoba;B. Paul Morgan

  • Compendium of current complement therapeutics

    Wioleta M Zelek;Long Xie;B Paul Morgan;Claire L Harris;Claire L Harris

  • Complement activation in multiple sclerosis plaques: an immunohistochemical analysis

    Gillian Ingram;Sam Loveless;Owain W Howell;Svetlana Hakobyan

  • Structural basis for complement Factor I control and its disease associated sequence polymorphisms

    P. Roversi;S. Johnson;J. J. E. Caesar;F. McLean

  • The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.

    Agustín Tortajada;Tamara Montes;Rubén Martı́nez-Barricarte;B. Paul Morgan

  • Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

    Bertrand Calippe;Sebastien Augustin;Fanny Beguier;Hugo Charles-Messance

  • Holding T cells in check--a new role for complement regulators?

    M. Paula Longhi;Claire L. Harris;B. Paul Morgan;Awen Gallimore

Frequent Co-Authors

B. Paul Morgan
B. Paul Morgan Cardiff University
Santiago Rodríguez de Córdoba
Santiago Rodríguez de Córdoba Spanish National Research Council
David J. Kavanagh
David J. Kavanagh Queensland University of Technology
Margarita López-Trascasa
Margarita López-Trascasa Autonomous University of Madrid
Timothy H.J. Goodship
Timothy H.J. Goodship Newcastle University
Susan M. Lea
Susan M. Lea University of Oxford
Oscar Llorca
Oscar Llorca Spanish National Research Council
Seiichi Matsuo
Seiichi Matsuo Nagoya University
Paul N. Barlow
Paul N. Barlow University of Edinburgh
Matthew C. Pickering
Matthew C. Pickering Imperial College London

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