2015 - Fellow, National Academy of Inventors
Stephen Tomlinson mainly investigates Complement system, Immunology, Complement membrane attack complex, Biochemistry and Alternative complement pathway. Complement system and Inflammation are commonly linked in his work. Stephen Tomlinson has researched Immunology in several fields, including Reperfusion injury and Receptor.
His studies examine the connections between Complement membrane attack complex and genetics, as well as such issues in CD59, with regards to Binding site and Monoclonal antibody therapy. In general Biochemistry, his work in Sialic acid, Trypanosoma brucei and Glycoprotein is often linked to Trypanosoma cruzi linking many areas of study. The various areas that Stephen Tomlinson examines in his Alternative complement pathway study include Complement factor B and Classical complement pathway.
Complement system, Immunology, Alternative complement pathway, Complement inhibitor and Inflammation are his primary areas of study. Stephen Tomlinson combines subjects such as Cancer research, Pharmacology and Cell biology with his study of Complement system. His study explores the link between Immunology and topics such as Reperfusion injury that cross with problems in Liver regeneration.
His research investigates the connection between Alternative complement pathway and topics such as Factor H that intersect with issues in CD46. His Complement inhibitor research includes themes of Decay-accelerating factor and Spinal cord injury, Spinal cord. Stephen Tomlinson works mostly in the field of Inflammation, limiting it down to concerns involving Stroke and, occasionally, Neuroinflammation.
His primary areas of investigation include Complement system, Immunology, Inflammation, Neuroinflammation and Complement inhibitor. Alternative complement pathway is the focus of his Complement system research. His Alternative complement pathway study integrates concerns from other disciplines, such as Haematopoiesis, Complement receptor 2, Factor H and Pharmacology.
His Immunology study frequently draws parallels with other fields, such as Spinal cord injury. His Neuroinflammation research is multidisciplinary, relying on both Stroke and Cognitive decline. His work carried out in the field of Complement inhibitor brings together such families of science as Vascularized Composite Allografts, Perfusion, Reperfusion injury, Opsonin and Monoclonal antibody.
Complement system, Immunology, Inflammation, Stroke and Alternative complement pathway are his primary areas of study. His Complement system research includes elements of Cancer research, Pathogenesis, Retina, Cell biology and Innate immune system. His study in Immunology is interdisciplinary in nature, drawing from both Reperfusion injury and Cell.
His study looks at the relationship between Inflammation and fields such as Complement, as well as how they intersect with chemical problems. His Stroke research is multidisciplinary, incorporating elements of Neuroimaging, Lesion, Surgery and Cortex. Stephen Tomlinson works mostly in the field of Alternative complement pathway, limiting it down to topics relating to Macular degeneration and, in certain cases, Gene delivery, Retinal pigment epithelium, Factor H and Complement receptor 2, as a part of the same area of interest.
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Complement function in mAb-mediated cancer immunotherapy
Kyra A. Gelderman;Stephen Tomlinson;Gordon D. Ross;Arko Gorter.
Trends in Immunology (2004)
Characterization of a Novel Trypanosome Lytic Factor from Human Serum
Jayne Raper;Ramie Fung;Jorge Ghiso;Victor Nussenzweig.
Infection and Immunity (1999)
Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury.
Joshua M. Thurman;Brandon Renner;Kannan Kunchithapautham;Viviana P. Ferreira.
Journal of Biological Chemistry (2009)
A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.
Ba¨rbel Rohrer;Qin Long;Beth Coughlin;R. Brooks Wilson.
Investigative Ophthalmology & Visual Science (2009)
Complement defense mechanisms
Current Opinion in Immunology (1993)
Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.
Carl Atkinson;Hongbin Song;Bo Lu;Fei Qiao.
Journal of Clinical Investigation (2005)
Complement-Mediated Mechanisms in Anti-GD2 Monoclonal Antibody Therapy of Murine Metastatic Cancer
Masaki Imai;Charles Landen;Rieko Ohta;Nai-Kong V. Cheung.
Cancer Research (2005)
Substrate specificity of the Trypanosoma cruzi trans-sialidase
Filip Vandekerckhove;Sergio Schenkman;Lain Pontes de Carvalho;Stephen Tomlinson.
Complement-independent, peroxide-induced antibody lysis of platelets in HIV-1-related immune thrombocytopenia.
Michael Nardi;Stephen Tomlinson;M.Alba Greco;Simon Karpatkin.
The induction of Trypanosoma cruzi trypomastigote to amastigote transformation by low pH.
S. Tomlinson;F. Vandekerckhove;U. Frevert;V. Nussenzweig.
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