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Biology and Biochemistry

D-Index
57
Citations
9995
World Ranking
13999
National Ranking
72

Overview

Sergio Schenkman is affiliated with the Federal University of Sao Paulo in Brazil. Their research predominantly spans fields such as Medicine and Biochemistry, Genetics and Molecular Biology. Within these fields, their work notably impacts subfields including Molecular Biology, Epidemiology, Public Health, Environmental and Occupational Health, Infectious Diseases, and Ecology.

The scientist's research topics cover various domains with a concentration on Trypanosoma species research and implications, alongside studies on Leishmaniasis. Additional focal areas include Biochemical and Molecular Research, Parasites and Host Interactions, Calcium signaling and nucleotide metabolism, Signaling Pathways in Disease, and Antibiotic Resistance in Bacteria.

Some of the recent scholarly papers authored or co-authored by Sergio Schenkman include:

  • Extracellular Vesicles in Trypanosomatids: Host Cell Communication, 2020, Frontiers in Cellular and Infection Microbiology
  • The translational challenge in Chagas disease drug development, 2022, Memórias do Instituto Oswaldo Cruz
  • Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites, 2022, mBio
  • Guidelines for the purification and characterization of extracellular vesicles of parasites, 2023, Journal of Extracellular Biology
  • Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity, 2020, Biochemical Journal

Frequent collaborators in their research include Nilmar Silvio Moretti, João Pedro Rueda Furlan, Ana Cláudia Torrecilhas, Carolina Borsoi Moraes, and Normanda Souza-Melo. These coauthors have contributed to multiple joint publications, reflecting ongoing collaborative efforts within the field.

Publication venues where Sergio Schenkman has frequently published include Frontiers in Cellular and Infection Microbiology, bioRxiv (Cold Spring Harbor Laboratory), mBio, Cellular Microbiology, and Cell Biology International. Their presence in these journals highlights work in cellular microbiology and infection biology within both preprint and peer-reviewed contexts.

Best Publications

  • A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells.

    Sergio Schenkman;Man Shiow Jiang;Gerald Warren Hart;Victor Nussenzweig

  • Structural and Functional Properties of Trypanosoma Trans-Sialidase

    S. Schenkman;D. Eichinger;M. E. A. Pereira;V Nussenzweig

  • Exocellular components of Paracoccidioides brasiliensis: identification of a specific antigen.

    R Puccia;S Schenkman;P A Gorin;L R Travassos

  • The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles.

    Alvaro Acosta-Serrano;Igor C. Almeida;Lucio H. Freitas-Junior;Nobuko Yoshida

  • Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies

    V.L. Pereira-Chioccola;A. Acosta-Serrano;I. Correia de Almeida;M.A. Ferguson

  • Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi

    Igor C. Almeida;Michael A. J. Ferguson;Sergio Schenkman;Luiz R. Travassos

  • Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development.

    Carolina B. Moraes;Miriam A. Giardini;Hwayoung Kim;Caio H. Franco

  • Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi

    Sergio Schenkman;Michael A.J. Ferguson;Norton Heise;Maria Lucia Cardoso de Almeida

  • The Lipid Structure of the Glycosylphosphatidylinositol-anchored Mucin-like Sialic Acid Acceptors of Trypanosoma cruzi Changes during Parasite Differentiation from Epimastigotes to Infective Metacyclic Trypomastigote Forms

    Alvaro Acosta Serrano;Sergio Schenkman;Nobuko Yoshida;Angela Mehlert

  • 'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase.

    Ivone Carvalho;Peterson Andrade;Vanessa L. Campo;Paulo M.M. Guedes

  • Trypanosoma cruzi trans-sialidase and neuraminidase activities can be mediated by the same enzymes.

    S Schenkman;L Pontes de Carvalho;V Nussenzweig

  • Trypanosoma cruzi trans-sialidase and cell invasion

    S. Schenkman;D. Eichinger

  • Substrate specificity of the Trypanosoma cruzi trans-sialidase

    Filip Vandekerckhove;Sergio Schenkman;Lain Pontes de Carvalho;Stephen Tomlinson

  • Purification of a glycosyl-phosphatidylinositol-specific phospholipase D from human plasma.

    M A Davitz;J Hom;S Schenkman

  • Attachment of Trypanosoma cruzi to mammalian cells requires parasite energy, and invasion can be independent of the target cell cytoskeleton.

    S Schenkman;E S Robbins;V Nussenzweig

  • Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice

    Fabio Costa;Giovanni Franchin;Vera Lucia Pereira-Chioccola;Marcelo Ribeirão

  • Effects of temperature and lipid composition on the serum albumin-induced aggregation and fusion of small unilamellar vesicles.

    S Schenkman;P S Araujo;R Dijkman;F H Quina

  • Transcription rate modulation through the Trypanosoma cruzi life cycle occurs in parallel with changes in nuclear organisation.

    Maria Carolina Q.B. Elias;Rafael Marques-Porto;Edna Freymüller;Sergio Schenkman

  • Morphological events during the Trypanosoma cruzi cell cycle.

    Maria Carolina Elias;Julia P C da Cunha;Flavio P de Faria;Renato A Mortara

  • Expression of trypomastigote trans‐sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole

    Sergio S. C. Rubin-de-Celis;Haruki Uemura;Nobuko Yoshida;Sergio Schenkman

Frequent Co-Authors

Mauricio M. Rodrigues
Mauricio M. Rodrigues Federal University of Sao Paulo
Igor C. Almeida
Igor C. Almeida The University of Texas at El Paso
Robert A. Field
Robert A. Field University of Manchester
Nobuko Yoshida
Nobuko Yoshida University of Oxford
Wanderley de Souza
Wanderley de Souza Federal University of Rio de Janeiro
Renato A. Mortara
Renato A. Mortara Federal University of Sao Paulo
Michael A. J. Ferguson
Michael A. J. Ferguson University of Dundee
Luiz R. Travassos
Luiz R. Travassos Federal University of Sao Paulo
Victor Nussenzweig
Victor Nussenzweig New York University
Andrea M. Macedo
Andrea M. Macedo Universidade Federal de Minas Gerais

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