Clotilde Lagier-Tourenne

Overview

Best Publications

• Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

  Magdalini Polymenidou;Clotilde Lagier-Tourenne;Kasey R. Hutt;Stephanie C. Huelga

  1360
  Citations

• TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

  Clotilde Lagier-Tourenne;Magdalini Polymenidou;Don W. Cleveland

  1150
  Citations

• Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

  Elizabeth T. Cirulli;Brittany N Lasseigne;Slave Petrovski;Peter C Sapp

  1045
  Citations

• Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

  Clotilde Lagier-Tourenne;Magdalini Polymenidou;Kasey R. Hutt;Anthony Q. Vu

  786
  Citations

• Rethinking ALS: The FUS about TDP-43

  Clotilde Lagier-Tourenne;Don W. Cleveland

  694
  Citations

• Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

  Clotilde Lagier-Tourenne;Michael Baughn;Frank Rigo;Shuying Sun

  631
  Citations

• Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

  Jie Jiang;Jie Jiang;Qiang Zhu;Tania F. Gendron;Shahram Saberi

  574
  Citations

• Animal models of neurodegenerative diseases.

  Ted M. Dawson;Todd E. Golde;Clotilde Lagier-Tourenne

  552
  Citations

• ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

  Shuo-Chien Ling;Claudio P. Albuquerque;Joo Seok Han;Clotilde Lagier-Tourenne

  504
  Citations

• ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

  Eveline S. Arnold;Shuo-Chien Ling;Stephanie C. Huelga;Clotilde Lagier-Tourenne

  485
  Citations

• Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.

  Ze’ev Melamed;Jone López-Erauskin;Michael W. Baughn;Ouyang Zhang

  443
  Citations

• Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

  Lin Guo;Hong Joo Kim;Hejia Wang;John Monaghan

  416
  Citations

• Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS.

  Kathrin Meyer;Laura Ferraiuolo;Carlos J. Miranda;Shibi Likhite;Shibi Likhite

  371
  Citations

• ADCK3, an Ancestral Kinase, Is Mutated in a Form of Recessive Ataxia Associated with Coenzyme Q10 Deficiency

  Clotilde Lagier-Tourenne;Meriem Tazir;Luis Carlos López;Catarina M. Quinzii

  346
  Citations

• Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia.

  Anika H.D.M. Dam;Isabelle Koscinski;Jan A.M. Kremer;Céline Moutou

  334
  Citations

• Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

  Andrea Crotti;Christopher Benner;Bilal E Kerman;David Gosselin

  328
  Citations

• C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

  Yong Jie Zhang;Tania F. Gendron;Jonathan C. Grima;Hiroki Sasaguri

  311
  Citations

• The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone

  Anna-Kaisa Anttonen;Ibrahim Mahjneh;Riikka H Hämäläinen;Clotilde Lagier-Tourenne

  262
  Citations

• ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.

  Shuying Sun;Shuo Chien Ling;Shuo Chien Ling;Jinsong Qiu;Claudio P. Albuquerque

  234
  Citations

• Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

  Jelena Scekic‐Zahirovic;Jelena Scekic‐Zahirovic;Oliver Sendscheid;Oliver Sendscheid;Hajer El Oussini;Hajer El Oussini;Mélanie Jambeau;Mélanie Jambeau

  233
  Citations