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Molecular Biology

D-Index
82
Citations
22808
World Ranking
940
National Ranking
70

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Michael J. Gait is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions also in Medicine.

The main subfields of study include Molecular Biology, Immunology, Genetics, Surgery, and Rehabilitation. Their research covers several key topics, such as Neurogenetic and Muscular Disorders Research, Muscle Physiology and Disorders, RNA modifications and cancer, RNA Interference and Gene Delivery, Exercise and Physiological Responses, Cardiac Structural Anomalies and Repair, and DNA and Nucleic Acid Chemistry.

Michael J. Gait has published in multiple venues, notable among them:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • JCI Insight
  • Methods in molecular biology
  • Nucleic Acid Therapeutics
  • Cells

Their recent papers include:

  • "Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy," 2022, JCI Insight
  • "Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides," 2021, Nucleic Acid Therapeutics
  • "Introduction and History of the Chemistry of Nucleic Acids Therapeutics," 2022, Methods in molecular biology
  • "Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy," 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • "Dystrophin involvement in peripheral circadian SRF signalling," 2021, Life Science Alliance

Frequent co-authors include:

  • Matthew J. A. Wood
  • Frank Abendroth
  • Graham McClorey
  • Suzan M. Hammond
  • Larissa Goli

Among the recognitions received, Michael J. Gait is a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Cell penetrating peptides

    Michael John Gait;Andrey Alexandrovich Arzumanov;Gabriela Dimitroval Ivanova

  • Nucleotide sequence of tobacco mosaic virus RNA

    P. Goelet;G. P. Lomonossoff;P. J. G. Butler;M. E. Akam

  • Phosphoramidite derivatives, their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides

    Konrad Misiura;Michael J. Gait

  • Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro

    Colin Dingwall;Ingemar Ernberg;Michael J. Gait;Sheila M. Green

  • HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure.

    Colin Dingwall;Ingemar Ernberg;Michael J. Gait;Sheila M. Green

  • miR-122 targeting with LNA/2′-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA–peptide conjugates

    Martin M. Fabani;Michael J. Gait

  • High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.

    Mark J. Churcher;Christina Lamont;François Hamy;Colin Dingwall

  • Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes

    George Slim;Michael J. Gait

  • Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans -activation in cells

    John J D Turner;Gabriela D. Ivanova;Birgit Verbeure;Donna Williams

  • Efficient methods for attaching non-radioactive labels to the 5' ends of synthetic oligodeoxyribonucleotides.

    Sudhir Agrawal;Chris Christodoulou;Michael J. Gait

  • Cell penetrating peptides: overview and applications to the delivery of oligonucleotides

    F. Said Hassane;A. F. Saleh;R. Abes;M. J. Gait

  • Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.

    Shaun Heaphy;John T. Finch;Michael J. Gait;Jonathan Karn

  • Delivery of therapeutic oligonucleotides with cell penetrating peptides

    Prisca Boisguérin;Sébastien Deshayes;Michael J. Gait;Liz O'Donovan

  • A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression

    D A Mann;I Mikaélian;R W Zemmel;S M Green

  • Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

    Martin M Fabani;Cei Abreu-Goodger;Donna Williams;Paul Anthony Lyons

  • Improved cell-penetrating peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle

    Gabriela D. Ivanova;Andrey Arzumanov;Rachida Abes;Haifang Yin

  • Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment

    Corinne Betts;Amer F Saleh;Andrey A Arzumanov;Suzan M Hammond

  • Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing.

    Pamela H. Hamlyn;George G. Brownlee;Chen-Chi Cheng;Michael J. Gait

  • Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues.

    Michael J. Gait

  • Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide

    Saïd Abes;John J D Turner;Gabriela D. Ivanova;David A. Owen

Frequent Co-Authors

Matthew J.A. Wood
Matthew J.A. Wood University of Oxford
Jonathan Karn
Jonathan Karn Case Western Reserve University
Jesper Wengel
Jesper Wengel Aalborg University
Colin Dingwall
Colin Dingwall King's College London
Samir El Andaloussi
Samir El Andaloussi Karolinska Institute
Andrew M. L. Lever
Andrew M. L. Lever University of Cambridge
Fritz Eckstein
Fritz Eckstein Max Planck Society
Bernard Lebleu
Bernard Lebleu University of Montpellier
Patrick L. Iversen
Patrick L. Iversen Oregon State University

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