World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
78
Citations
20889
World Ranking
1292
National Ranking
571

Molecular Biology

D-Index
78
Citations
20749
World Ranking
1082
National Ranking
563

Overview

Jonathan Karn is affiliated with Case Western Reserve University in the United States. Their research focuses primarily on HIV/AIDS, with extensive work in immunology, virology, and infectious diseases. Karn's scholarly output spans various aspects of HIV research, including viral latency, neuroinflammation, and immune cell function.

Their recent contributions include studies published in prominent journals such as Nature Medicine, Trends in Immunology, EMBO Molecular Medicine, The Journal of Infectious Diseases, and Clinical Infectious Diseases. Notable papers include:

  • Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial (2022, Nature Medicine)
  • The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder (2022, Trends in Immunology)
  • Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress (2021, EMBO Molecular Medicine)
  • A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy (2020, The Journal of Infectious Diseases)
  • Sex Differences in Human Immunodeficiency Virus Persistence and Reservoir Size During Aging (2021, Clinical Infectious Diseases)

Karn collaborates frequently with researchers including Uri Mbonye, Kien Nguyen, Konstantin Leskov, Curtis Dobrowolski, and Meenakshi Shukla. These collaborations reflect a network of expertise converging on HIV pathogenesis, treatment strategies, and molecular mechanisms governing viral persistence.

Their research is published recurrently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Virus Eradication, PLoS Pathogens, Trends in Immunology, and Retrovirology. These journals provide platforms focusing on virology, immunology, and infectious diseases, aligning with Karn's main fields of study.

The main fields of study for Karn's work are Immunology and Microbiology and Medicine. Subfields include:

  • Virology
  • Infectious Diseases
  • Immunology
  • Molecular Biology
  • Epidemiology

The core topics covered by Karn's research emphasize:

  • HIV Research and Treatment
  • Immune Cell Function and Interaction
  • HIV/AIDS Research and Interventions
  • Cytomegalovirus and herpesvirus research
  • HIV-related health complications and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • HIV/AIDS drug development and treatment

Overall, Jonathan Karn's scientific work contributes to understanding HIV latency, viral persistence mechanisms, and the interactions between HIV and the immune system, with implications for treatment and disease management.

Best Publications

  • Toward a physical map of the genome of the nematode Caenorhabditis elegans

    Alan Coulson;John Sulston;Sydney Brenner;Jonathan Karn

  • Nucleotide sequence of tobacco mosaic virus RNA

    P. Goelet;G. P. Lomonossoff;P. J. G. Butler;M. E. Akam

  • Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro

    Colin Dingwall;Ingemar Ernberg;Michael J. Gait;Sheila M. Green

  • RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

    Wenhui Hu;Rafal Kaminski;Fan Yang;Yonggang Zhang

  • Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression

    Jonathan Karn;C. Martin Stoltzfus

  • Periodic charge distributions in the myosin rod amino acid sequence match cross-bridge spacings in muscle

    Andrew D. McLachlan;Jonathan Karn

  • HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure.

    Colin Dingwall;Ingemar Ernberg;Michael J. Gait;Sheila M. Green

  • The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat Protein

    Fareed Aboul-ela;Jonathan Karn;Gabriele Varani

  • Novel bacteriophage lambda cloning vector

    Jonathan Karn;Sydney Brenner;Leslie Barnett;Gianni Cesareni

  • HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region

    Shaun Heaphy;Colin Dingwall;Ingemar Ernberg;Michaet J. Gait

  • Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

    Richard Pearson;Young Kyeung Kim;Joseph Hokello;Kara Lassen

  • Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing.

    Rafal Kaminski;Yilan Chen;Tracy Fischer;Ellen Tedaldi

  • An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

    François Hamy;Eduard R. Felder;Gerhard Heizmann;Janis Lazdins

  • High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.

    Mark J. Churcher;Christina Lamont;François Hamy;Colin Dingwall

  • Periodic features in the amino acid sequence of nematode myosin rod.

    Andrew D. McLachlan;Jonathan Karn

  • Structure of HIV-1 TAR RNA in the Absence of Ligands Reveals a Novel Conformation of the Trinucleotide Bulge

    Fareed Aboul-ela;Jonathan Karn;Gabriele Varani

  • Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis

    Theo Nikiforov;Jonathan Karn;Philip Goelet

  • Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

    Julia Friedman;Won Kyung Cho;Chung K. Chu;Kara S. Keedy

  • Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.

    Jonathan Karn;Sydney Brenner;Leslie Barnett

  • Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

    Mudit Tyagi;Richard John Pearson;Jonathan Karn

Frequent Co-Authors

Michael J. Gait
Michael J. Gait MRC Laboratory of Molecular Biology
Sydney Brenner
Sydney Brenner Agency for Science, Technology and Research
Gabriele Varani
Gabriele Varani University of Washington
Colin Dingwall
Colin Dingwall King's College London
Steven G. Deeks
Steven G. Deeks University of California, San Francisco
David M. Miller
David M. Miller Vanderbilt University
Michael A. Skinner
Michael A. Skinner Imperial College London
Kamel Khalili
Kamel Khalili Temple University
Rebecca Hoh
Rebecca Hoh University of California, San Francisco
Sharon R. Lewin
Sharon R. Lewin University of Melbourne

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Molecular Biology provides a strong foundation for numerous career options and further studies. Many students explore related online programs to enhance their expertise or pivot into growing fields. For example, an online architecture degree combines creative problem-solving with scientific knowledge, offering opportunities to apply biological principles in building design, sustainability, and urban planning.

Those interested in quantitative research or advanced data analysis may consider online math degree programs. These programs support careers in bioinformatics and systems biology, both of which are critical in modern molecular research.

Creativity-minded students can blend their scientific skills with the arts by pursuing a graphic design degree online. This pathway opens roles in biomedical illustration, digital media, and educational content creation—fields that serve to communicate complex biological concepts visually.

Interdisciplinary knowledge is increasingly valuable. Students seeking flexible education options should explore online interdisciplinary studies tuition costs to find programs that merge sciences, technology, and the humanities. These degrees boost versatility for those aiming to solve multifaceted problems across industries.

Best Scientists Citing Jonathan Karn

Trending Scientists