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Hashim M. Al-Hashimi

Hashim M. Al-Hashimi

D-Index & Metrics

Chemistry

D-Index
66
Citations
12799
World Ranking
7449
National Ranking
2190

Overview

Hashim M. Al-Hashimi is affiliated with Duke University in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a substantial concentration in Molecular Biology. Other subfields of study include Spectroscopy, Cardiology and Cardiovascular Medicine, Materials Chemistry, and Nuclear and High Energy Physics.

The main topics addressed in their work cover a range of areas related to nucleic acids and proteins. These include:

  • RNA and protein synthesis mechanisms
  • DNA and Nucleic Acid Chemistry
  • RNA Research and Splicing
  • RNA modifications and cancer
  • DNA Repair Mechanisms
  • Protein Structure and Dynamics
  • Advanced NMR Techniques and Applications

Significant recent papers authored or co-authored by Hashim M. Al-Hashimi demonstrate a focus on nucleic acid dynamics, molecular recognition, and computational advances. Selected examples from 2020 to 2024 include:

  • DNA mismatches reveal conformational penalties in protein-DNA recognition, 2020, Nature
  • 2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states, 2020, Nucleic Acids Research
  • Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction, 2020, Nature Communications
  • AlphaFold3 takes a step toward decoding molecular behavior and biological computation, 2024, Nature Structural & Molecular Biology
  • Developments in solution-state NMR yield broader and deeper views of the dynamic ensembles of nucleic acids, 2021, Current Opinion in Structural Biology

Their frequent co-authors include Honglue Shi, Atul Rangadurai, Bei Liu, Rohit Roy, and Stephanie Gu, indicating collaborative work especially in molecular biology and structural studies.

Hashim M. Al-Hashimi's research has been published in multiple venues with notable frequency, reflecting their active engagement in both preprint and peer-reviewed scientific communication. Key publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Proceedings of the National Academy of Sciences
  • Nature
  • Nucleic Acids Research

Best Publications

  • NMR structures of biomolecules using field oriented media and residual dipolar couplings.

    J. H. Prestegard;H. M. Al-Hashimi;J. R. Tolman

  • The roles of structural dynamics in the cellular functions of RNAs.

    Laura R Ganser;Megan L Kelly;Daniel Herschlag;Hashim M Al-Hashimi

  • Transient Hoogsteen base pairs in canonical duplex DNA

    Evgenia N. Nikolova;Eunae Kim;Abigail A. Wise;Patrick J. O’Brien

  • RNA dynamics: It is about time

    Hashim M Al-Hashimi;Nils G Walter

  • Functional complexity and regulation through RNA dynamics

    Elizabeth A. Dethoff;Jeetender Chugh;Anthony M. Mustoe;Hashim M. Al-Hashimi

  • Structural and Dynamic Analysis of Residual Dipolar Coupling Data for Proteins

    Joel R. Tolman;Hashim M. Al-Hashimi;Lewis E. Kay;James H. Prestegard

  • Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble

    Andrew C Stelzer;Aaron T Frank;Jeremy D Kratz;Michael D Swanson

  • Visualizing spatially correlated dynamics that directs RNA conformational transitions

    Qi Zhang;Andrew C. Stelzer;Charles K. Fisher;Hashim M. Al-Hashimi

  • Visualizing transient Watson–Crick-like mispairs in DNA and RNA duplexes

    Isaac J. Kimsey;Katja Petzold;Bharathwaj Sathyamoorthy;Zachary W. Stein

  • Resolving the motional modes that code for RNA adaptation.

    Qi Zhang;Xiaoyan Sun;Eric D. Watt;Hashim M. Al-Hashimi

  • Visualizing transient low-populated structures of RNA

    Elizabeth A. Dethoff;Katja Petzold;Jeetender Chugh;Anette Casiano-Negroni

  • Topology links RNA secondary structure with global conformation, dynamics, and adaptation.

    Maximillian H. Bailor;Xiaoyan Sun;Hashim M. Al-Hashimi

  • Hierarchy of RNA functional dynamics

    Anthony M. Mustoe;Charles L. Brooks;Hashim M. Al-Hashimi

  • Variation of Molecular Alignment as a Means of Resolving Orientational Ambiguities in Protein Structures from Dipolar Couplings

    H. M. Al-Hashimi;H. M. Al-Hashimi;Homayoun Valafar;M. Terrell;E. R. Zartler

  • Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings.

    Hashim M Al-Hashimi;Yuying Gosser;Andrey Gorin;Weidong Hu

  • Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy

    Jameson R Bothe;Evgenia N Nikolova;Catherine D Eichhorn;Jeetender Chugh

  • Extending the Range of Microsecond-to-Millisecond Chemical Exchange Detected in Labeled and Unlabeled Nucleic Acids by Selective Carbon R1ρ NMR Spectroscopy

    Alexandar L. Hansen;Evgenia N. Nikolova;Anette Casiano-Negroni;Hashim M. Al-Hashimi

  • Dynamic basis for dG•dT misincorporation via tautomerization and ionization

    Isaac J. Kimsey;Eric S. Szymanski;Walter J. Zahurancik;Anisha Shakya

  • m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs

    Huiqing Zhou;Isaac J Kimsey;Evgenia N Nikolova;Bharathwaj Sathyamoorthy

  • Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition

    Aaron T. Frank;Andrew C. Stelzer;Hashim M. Al-Hashimi;Ioan Andricioaei

  • Rapid determination of protein folds using residual dipolar couplings.

    C.Andrew Fowler;C.Andrew Fowler;Fang Tian;Hashim M. Al-Hashimi;Hashim M. Al-Hashimi;James H. Prestegard

Frequent Co-Authors

Charles L. Brooks
Charles L. Brooks University of Michigan–Ann Arbor
Dinshaw J. Patel
Dinshaw J. Patel Memorial Sloan Kettering Cancer Center
James H. Prestegard
James H. Prestegard University of Georgia
Daniel Herschlag
Daniel Herschlag Stanford University
David A. Case
David A. Case Rutgers, The State University of New Jersey
Hal P. Bogerd
Hal P. Bogerd Duke University
Bryan R. Cullen
Bryan R. Cullen Duke University
Carol A. Fierke
Carol A. Fierke Texas A&M University
Steve Scheiner
Steve Scheiner Utah State University
Rhiju Das
Rhiju Das Stanford University

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