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Shiroh Futaki

Shiroh Futaki

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
31090
World Ranking
3637
National Ranking
230

Overview

Shiroh Futaki is affiliated with Kyoto University in Japan and specializes in Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology as the primary subfield of study. Their research encompasses a range of topics, notably RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, Lipid Membrane Structure and Behavior, Extracellular vesicles in disease, Antimicrobial Peptides and Activities, Cellular transport and secretion, and Monoclonal and Polyclonal Antibodies Research.

The scientist has contributed extensively to research literature, with notable recent papers including the following:

  • Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides (2021, Angewandte Chemie International Edition)
  • Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules (2020, Angewandte Chemie International Edition)
  • Environmental pH stress influences cellular secretion and uptake of extracellular vesicles (2021, FEBS Open Bio)
  • Recognition of G-quadruplex RNA by a crucial RNA methyltransferase component, METTL14 (2021, Nucleic Acids Research)
  • Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane-Lytic Peptides To Facilitate Endosomal Escape (2020, Bioconjugate Chemistry)

Frequent co-authors include H. Hirose, Miki Imanishi, Yoshimasa Kawaguchi, Jan Vincent V. Arafiles, and Kenichi Kawano. These collaborations have contributed to a significant body of work represented across various research outputs.

Publication venues where they have frequently appeared include:

  • Bioconjugate Chemistry
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Bioorganic & Medicinal Chemistry Letters
  • Molecular Pharmaceutics

The scientist's investigations often involve biochemical approaches to cellular transport mechanisms, membrane interactions, and nucleic acid delivery systems. Their work explores the behavior and modulation of peptides, mechanisms of intracellular delivery, and the influence of environmental factors on cellular processes.

Best Publications

  • The Transcriptional Landscape of the Mammalian Genome

    P. Carninci;T. Kasukawa;S. Katayama;J. Gough

  • Arginine-rich Peptides: AN ABUNDANT SOURCE OF MEMBRANE-PERMEABLE PEPTIDES HAVING POTENTIAL AS CARRIERS FOR INTRACELLULAR PROTEIN DELIVERY *

    Shiroh Futaki;Tomoki Suzuki;Wakana Ohashi;Takeshi Yagami

  • Mechanisms of Cellular Uptake of Cell-Penetrating Peptides

    Fatemeh Madani;Staffan Lindberg;Ülo Langel;Shiroh Futaki

  • Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement.

    Ikuhiko Nakase;Miki Niwa;Toshihide Takeuchi;Kazuhiro Sonomura

  • Possible existence of common internalization mechanisms among arginine-rich peptides.

    Tomoki Suzuki;Shiroh Futaki;Miki Niwa;Seigo Tanaka

  • Stearylated arginine-rich peptides: a new class of transfection systems.

    Shiroh Futaki;Wakana Ohashi;Tomoki Suzuki;Miki Niwa

  • Membrane-permeable arginine-rich peptides and the translocation mechanisms

    Shiroh Futaki

  • Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment.

    Ayman El-Sayed;Shiroh Futaki;Hideyoshi Harashima

  • Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis.

    Ikuhiko Nakase;Akiko Tadokoro;Noriko Kawabata;Toshihide Takeuchi

  • High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

    Kohsuke Inomata;Ayako Ohno;Hidehito Tochio;Shin Isogai

  • Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides.

    Ikuhiko Nakase;Toshihide Takeuchi;Gen Tanaka;Shiroh Futaki

  • High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression

    Ikramy A. Khalil;Kentaro Kogure;Shiroh Futaki;Hideyoshi Harashima

  • Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides

    Ikuhiko Nakase;Hidetaka Akita;Kentaro Kogure;Astrid Gräslund

  • Direct and rapid cytosolic delivery using cell-penetrating peptides mediated by pyrenebutyrate.

    Toshihide Takeuchi;Michie Kosuge;Akiko Tadokoro;Yukio Sugiura

  • Cellular Internalization and Distribution of Arginine-Rich Peptides as a Function of Extracellular Peptide Concentration, Serum, and Plasma Membrane Associated Proteoglycans

    Michie Kosuge;Toshihide Takeuchi;Ikuhiko Nakase;Arwyn Tomos Jones

  • Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system.

    Tomoyuki Kakudo;Shinji Chaki;Shiroh Futaki;Ikuhiko Nakase

  • Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

    Misao Akishiba;Toshihide Takeuchi;Yoshimasa Kawaguchi;Kentarou Sakamoto

  • Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method.

    Kentaro Kogure;Rumiko Moriguchi;Kentaro Sasaki;Masaharu Ueno

  • Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells.

    Marjan M. Fretz;Marjan M. Fretz;Neal Aart Penning;Saly Al-Taei;Shiroh Futaki;Shiroh Futaki

  • Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms.

    Shiroh Futaki

Frequent Co-Authors

Yukio Sugiura
Yukio Sugiura Kyoto University
Hideyoshi Harashima
Hideyoshi Harashima Hokkaido University
Kentaro Kogure
Kentaro Kogure University of Tokushima
Hidetaka Akita
Hidetaka Akita Chiba University
Nobutaka Fujii
Nobutaka Fujii Kyoto University
Kunihiro Ueda
Kunihiro Ueda Kyoto University
Astrid Gräslund
Astrid Gräslund Stockholm University
Stefan Matile
Stefan Matile University of Geneva
Ülo Langel
Ülo Langel Stockholm University
Naomi Sakai
Naomi Sakai University of Geneva

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