Hidetaka Akita

Overview

Best Publications

• Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery

  Ikramy A. Khalil;Kentaro Kogure;Hidetaka Akita;Hideyoshi Harashima

  1497
  Citations

• A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma.

  Hiroto Hatakeyama;Hidetaka Akita;Hideyoshi Harashima

  686
  Citations

• Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.

  H Hatakeyama;H Akita;K Kogure;M Oishi

  488
  Citations

• The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors.

  Hiroto Hatakeyama;Hidetaka Akita;Hideyoshi Harashima

  468
  Citations

• The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

  Seiichi Sato;Kai Li;Takeshi Kameyama;Takaya Hayashi

  459
  Citations

• Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides

  Ikuhiko Nakase;Hidetaka Akita;Kentaro Kogure;Astrid Gräslund

  413
  Citations

• MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

  Yuma Yamada;Hidetaka Akita;Hiroyuki Kamiya;Kentaro Kogure

  360
  Citations

• A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

  Yusuke Sato;Hiroto Hatakeyama;Yu Sakurai;Mamoru Hyodo

  319
  Citations

• Quantitative Comparison of Intracellular Trafficking and Nuclear Transcription between Adenoviral and Lipoplex Systems

  Susumu Hama;Hidetaka Akita;Rie Ito;Hiroyuki Mizuguchi

  314
  Citations

• Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery

  Tooru Ooya;Hak Soo Choi;Atsushi Yamashita;Nobuhiko Yui

  306
  Citations

• A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.

  Hiroto Hatakeyama;Erika Ito;Hidetaka Akita;Motoi Oishi

  290
  Citations

• Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system.

  Kentaro Kogure;Hidetaka Akita;Yuma Yamada;Hideyoshi Harashima

  250
  Citations

• Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.

  Hidetaka Akita;Hiroshi Suzuki;Kousei Ito;Setsuo Kinoshita

  247
  Citations

• Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid.

  Hiroto Hatakeyama;Hidetaka Akita;Erika Ito;Yasuhiro Hayashi

  245
  Citations

• Pharmacokinetics and brain uptake of lactoferrin in rats.

  Bin Ji;Jun Maeda;Makoto Higuchi;Kaori Inoue

  226
  Citations

• Reprint of: Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation.

  Hidetaka Akita;Kentaro Kogure;Rumiko Moriguchi;Yoshio Nakamura

  222
  Citations

• Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes

  Hiroto Hatakeyama;Hidetaka Akita;Emi Ishida;Koichi Hashimoto

  220
  Citations

• Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery

  I A Khalil;K Kogure;S Futaki;S Hama

  204
  Citations

• Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo.

  Hiroto Hatakeyama;Hidetaka Akita;Kazuo Maruyama;Tetsuya Suhara

  204
  Citations

• Photosensitized Breakage and Damage of DNA by CdSe-ZnS Quantum Dots

  AbdulAziz Anas;Hidetaka Akita;Hideyoshi Harashima;Tamitake Itoh

  195
  Citations