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Naohiko Anzai

Naohiko Anzai

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
11088
World Ranking
12680
National Ranking
871

Overview

Naohiko Anzai is affiliated with Chiba University in Japan and has contributed extensively to research mainly in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, including Molecular Biology, Biochemistry, Oncology, Nephrology, and Pulmonary and Respiratory Medicine.

The scientist's research topics focus on amino acid enzymes and metabolism, epigenetics and DNA methylation, gout, hyperuricemia and uric acid, drug transport and resistance mechanisms, prostate cancer treatment and research, metabolism and genetic disorders, and adenosine and purinergic signaling.

Naohiko Anzai has published multiple papers with notable examples including:

  • Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma (2020, Scientific Reports)
  • Uric Acid Elevation by Favipiravir, an Antiviral Drug (2020, The Tohoku Journal of Experimental Medicine)
  • Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer (2020, Translational Oncology)
  • Recent approaches to gout drug discovery: an update (2020, Expert Opinion on Drug Discovery)
  • L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism (2021, Scientific Reports)

Frequent co-authors in their scientific work include Shinichi Sakamoto, Shinpei Saito, Tomohiko Ichikawa, Yusuke Imamura, and Yoshie Reien.

Naohiko Anzai has published many papers in the following venues:

  • Proceedings for Annual Meeting of The Japanese Pharmacological Society
  • Scientific Reports
  • Journal of Pharmacological Sciences
  • Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
  • Cancer Science

Best Publications

  • Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans.

    Naohiko Anzai;Kimiyoshi Ichida;Promsuk Jutabha;Toru Kimura

  • L-type amino acid transporter 1 inhibitors inhibit tumor cell growth.

    Koji Oda;Noriko Hosoda;Hiroshi Endo;Kunio Saito

  • Organic anion transporter family: current knowledge.

    Naohiko Anzai;Yoshikatsu Kanai;Hitoshi Endou

  • Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules

    Sophapun Ekaratanawong;Naohiko Anzai;Promsuk Jutabha;Hiroki Miyazaki

  • Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder.

    Robert Kleta;Elisa Romeo;Zorica Ristic;Toshihiro Ohura

  • New insights into renal transport of urate.

    Naohiko Anzai;Yoshikatsu Kanai;Hitoshi Endou

  • Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.

    Atsushi Enomoto;Michael F. Wempe;Hiroki Tsuchida;Ho Jung Shin

  • The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus.

    Naohiko Anzai;Hiroki Miyazaki;Hiroki Miyazaki;Rie Noshiro;Suparat Khamdang

  • Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters

    Ellappan Babu;Yoshikatsu Kanai;Arthit Chairoungdua;Do Kyung Kim

  • Interactions of Human Organic Anion Transporters and Human Organic Cation Transporters with Nonsteroidal Anti-Inflammatory Drugs

    Suparat Khamdang;Michio Takeda;Rie Noshiro;Shinichi Narikawa

  • Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells.

    Do Kyung Kim;Yoshikatsu Kanai;Yoshikatsu Kanai;Hye Won Choi;Sahatchai Tangtrongsup

  • Interactions of Human Organic Anion Transporters with Diuretics

    Habib Hasannejad;Michio Takeda;Kentarou Taki;Ho Jung Shin

  • Human Sodium Phosphate Transporter 4 (hNPT4/SLC17A3) as a Common Renal Secretory Pathway for Drugs and Urate

    Promsuk Jutabha;Naohiko Anzai;Kenichiro Kitamura;Atsuo Taniguchi

  • LAT1 Is a Critical Transporter of Essential Amino Acids for Immune Reactions in Activated Human T Cells

    Keitaro Hayashi;Promsuk Jutabha;Hitoshi Endou;Hironori Sagara

  • Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate†

    Ho Jung Shin;Naohiko Anzai;Atsushi Enomoto;Xin He

  • Identification of a Novel Voltage-driven Organic Anion Transporter Present at Apical Membrane of Renal Proximal Tubule

    Promsuk Jutabha;Yoshikatsu Kanai;Makoto Hosoyamada;Arthit Chairoungdua

  • Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter.

    Masafumi Iharada;Takaaki Miyaji;Takahiro Fujimoto;Miki Hiasa

  • High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions.

    Masaaki Ichinoe;Tetuo Mikami;Tsutomu Yoshida;Ikuyo Igawa

  • Modulation of Renal Apical Organic Anion Transporter 4 Function by Two PDZ Domain–Containing Proteins

    Hiroki Miyazaki;Naohiko Anzai;Sophapun Ekaratanawong;Takeshi Sakata

  • Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions.

    Takeshi Sakata;Naohiko Anzai;Ho Jung Shin;Rie Noshiro

Frequent Co-Authors

Hitoshi Endou
Hitoshi Endou Kyorin University
Yoshikatsu Kanai
Yoshikatsu Kanai Osaka University
Hidetaka Akita
Hidetaka Akita Chiba University
Atsushi Enomoto
Atsushi Enomoto Nagoya University
Yuzuru Ikehara
Yuzuru Ikehara Chiba University
Atsushi Iwama
Atsushi Iwama University of Tokyo
Hermann Koepsell
Hermann Koepsell University of Würzburg
Carsten A. Wagner
Carsten A. Wagner University of Zurich
Hisashi Yamanaka
Hisashi Yamanaka International University of Health and Welfare
Sanjay K. Nigam
Sanjay K. Nigam University of California, San Diego

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