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Atsushi Iwama

Atsushi Iwama

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
23964
World Ranking
4280
National Ranking
278

Overview

Atsushi Iwama is affiliated with the University of Tokyo in Japan and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, hematology, immunology, genetics, and oncology. The work primarily focuses on the biology and treatment of hematopoietic stem cells, epigenetics, and cancer-related immune processes.

The scientist's research interests include:

  • Acute Myeloid Leukemia Research
  • Epigenetics and DNA Methylation
  • Hematopoietic Stem Cell Transplantation
  • Multiple Myeloma Research and Treatments
  • Protein Degradation and Inhibitors
  • Immune cells in cancer
  • Immune Cell Function and Interaction

Key recent publications illustrating their research contributions include:

  • "Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice," 2021, Nature Aging
  • "Chemically defined cytokine-free expansion of human haematopoietic stem cells," 2023, Nature
  • "Obesity accelerates hair thinning by stem cell-centric converging mechanisms," 2021, Nature
  • "Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche," 2020, The Journal of Experimental Medicine
  • "Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells," 2022, Nature Communications

Frequently publishing venues include:

  • Experimental Hematology
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Leukemia

The scientist collaborates regularly with several researchers, including:

  • Motohiko Oshima
  • Shuhei Koide
  • Yaeko Nakajima-Takagi
  • Masayuki Yamashita
  • Kazumasa Aoyama

Best Publications

  • The Transcriptional Landscape of the Mammalian Genome

    P. Carninci;T. Kasukawa;S. Katayama;J. Gough

  • Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.

    Tetsuhiro Chiba;Kaoru Kita;Yun-Wen Zheng;Osamu Yokosuka

  • Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

    Satoshi Yamazaki;Hideo Ema;Göran Karlsson;Tomoyuki Yamaguchi

  • Enhanced self-renewal of hematopoietic stem cells mediated by the Polycomb gene product Bmi-1

    Atsushi Iwama;Hideyuki Oguro;Masamitsu Negishi;Yuko Kato

  • Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.

    Pu Zhang;Gerhard Behre;Jing Pan;Atsushi Iwama

  • PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

    Pu Zhang;Xiaobo Zhang;Atsushi Iwama;Channing Yu

  • TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

    Satoshi Yamazaki;Atsushi Iwama;Shin-ichiro Takayanagi;Koji Eto

  • Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

    Satoshi Yamazaki;Atsushi Iwama;Atsushi Iwama;Shin-ichiro Takayanagi;Yohei Morita

  • Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.

    Tze Mun Loo;Fumitaka Kamachi;Yoshihiro Watanabe;Shin Yoshimoto

  • c-Myc is a critical target for c/EBPalpha in granulopoiesis.

    Lisa M. Johansen;Atsushi Iwama;Tracey A. Lodie;Koichi Sasaki

  • Array-based genomic resequencing of human leukemia

    Y Yamashita;J Yuan;I Suetake;H Suzuki

  • Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

    Hiromi Yuasa;Yuichi Oike;Atsushi Iwama;Ichiro Nishikata

  • Essential and Instructive Roles of GATA Factors in Eosinophil Development

    Ryutaro Hirasawa;Ritsuko Shimizu;Satoru Takahashi;Mitsujiro Osawa;Mitsujiro Osawa

  • Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.

    Tetsuhiro Chiba;Yun-Wen Zheng;Kaoru Kita;Osamu Yokosuka

  • MOZ is essential for maintenance of hematopoietic stem cells.

    Takuo Katsumoto;Yukiko Aikawa;Atsushi Iwama;Shinobu Ueda

  • Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

    Hideyuki Oguro;Atsushi Iwama;Yohei Morita;Takehiko Kamijo

  • Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells.

    Atsushi Suzuki;Atsushi Iwama;Hitoshi Miyashita;Hiromitsu Nakauchi

  • Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells

    Makiko Mochizuki-Kashio;Yuta Mishima;Satoru Miyagi;Masamitsu Negishi

  • Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.

    Hideyuki Oguro;Jin Yuan;Hitoshi Ichikawa;Tomokatsu Ikawa

  • The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma

    Tetsuhiro Chiba;Satoru Miyagi;Atsunori Saraya;Ryutaro Aoki

Frequent Co-Authors

Hiromitsu Nakauchi
Hiromitsu Nakauchi Stanford University
Haruhiko Koseki
Haruhiko Koseki RIKEN Center for Integrative Medical Sciences
Osamu Yokosuka
Osamu Yokosuka Chiba University
Toshio Suda
Toshio Suda National University of Singapore
Kazuya Shimoda
Kazuya Shimoda University of Miyazaki
Koji Eto
Koji Eto Kyoto University
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Motomi Osato
Motomi Osato National University of Singapore
Toshio Kitamura
Toshio Kitamura University of Tokyo
Seishi Ogawa
Seishi Ogawa Kyoto University

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