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Biology and Biochemistry

D-Index
57
Citations
21362
World Ranking
13531
National Ranking
946

Overview

Koji Eto is affiliated with Kyoto University in Japan, where their work primarily focuses on the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans several subfields, including hematology, molecular biology, immunology, biomedical engineering, and surgery.

Their main scientific topics cover platelet disorders and treatments, pluripotent stem cells research, pancreatic function and diabetes, 3D printing in biomedical research, hematopoietic stem cell transplantation, CRISPR and genetic engineering, and periodontal regeneration and treatments.

Koji Eto has contributed to a significant array of research articles, frequently publishing in venues such as Blood, Nature Communications, PubMed, bioRxiv (Cold Spring Harbor Laboratory), and Blood Advances. These journals have been key platforms for disseminating their work.

  • iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study (2022, Blood)
  • Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (2022, Nature Communications)
  • Production and nonclinical evaluation of an autologous iPSC-derived platelet product for the iPLAT1 clinical trial (2022, Blood Advances)
  • Generation and manipulation of human iPSC-derived platelets (2021, Cellular and Molecular Life Sciences)
  • The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis (2020, Blood)

The scientist collaborates regularly with several key coauthors, including Sou Nakamura, Naoshi Sugimoto, Naoya Takayama, Atsushi Iwama, and Sudip Kumar Paul. These collaborations reflect a strong network within their research community.

  • Sou Nakamura
  • Naoshi Sugimoto
  • Naoya Takayama
  • Atsushi Iwama
  • Sudip Kumar Paul

Their research consistently addresses topics related to stem cell biology and hematopoiesis, with a particular emphasis on platelet generation and related disorders. Techniques in genetic engineering and cellular manipulation appear frequently in their work, demonstrating a blend of biomedical engineering principles with clinical applications.

Best Publications

  • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

    T Yamauchi;J Kamon;Y Minokoshi;Y Ito

  • CD8 + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

    Satoshi Nishimura;Ichiro Manabe;Mika Nagasaki;Koji Eto

  • Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

    Seiji Tadokoro;Sanford J. Shattil;Koji Eto;Vera Tai

  • Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton

    Achim Obergfell;Koji Eto;Attila Mocsai;Charito Buensuceso

  • Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors

    Naoya Takayama;Hidekazu Nishikii;Joichi Usui;Hiroko Tsukui

  • Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation

    Toshinobu Nishimura;Shin Kaneko;Ai Kawana-Tachikawa;Yoko Tajima

  • TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

    Satoshi Yamazaki;Atsushi Iwama;Shin-ichiro Takayanagi;Koji Eto

  • Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

    Satoshi Yamazaki;Atsushi Iwama;Atsushi Iwama;Shin-ichiro Takayanagi;Yohei Morita

  • Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.

    Naoya Takayama;Satoshi Nishimura;Satoshi Nishimura;Sou Nakamura;Takafumi Shimizu

  • Essential in vivo roles of the c-type lectin receptor CLEC-2: Embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets

    Katsue Suzuki-Inoue;Osamu Inoue;Guo Ding;Satoshi Nishimura

  • Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

    Masatoshi Kajiwara;Takashi Aoi;Keisuke Okita;Ryosuke Takahashi

  • Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells

    Sou Nakamura;Naoya Takayama;Shinji Hirata;Hideya Seo

  • Turbulence activates platelet biogenesis to enable clinical scale ex vivo production

    Yukitaka Ito;Sou Nakamura;Naoshi Sugimoto;Tomohiro Shigemori

  • RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

    Koji Eto;Wilma Puzon-McLaughlin;Dean Sheppard;Atsuko Sehara-Fujisawa

  • IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.

    Satoshi Nishimura;Satoshi Nishimura;Satoshi Nishimura;Mika Nagasaki;Shinji Kunishima;Akira Sawaguchi

  • Relationships between Rap1b, Affinity Modulation of Integrin αIIbβ3, and the Actin Cytoskeleton

    Alessandra Bertoni;Seiji Tadokoro;Koji Eto;Nisar Pampori

  • TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

    Toshihiro Fujii;Asuka Sakata;Satoshi Nishimura;Koji Eto

  • Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation

    Satoshi Nishimura;Ichiro Manabe;Satoshi Takaki;Mika Nagasaki

  • Functional Classification of ADAMs Based on a Conserved Motif for Binding to Integrin α9β1 IMPLICATIONS FOR SPERM-EGG BINDING AND OTHER CELL INTERACTIONS

    Koji Eto;Clotilde Huet;Takehiko Tarui;Sergey Kupriyanov

  • Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling

    Koji Eto;Ronan Murphy;Steve W. Kerrigan;Alessandra Bertoni

Frequent Co-Authors

Hiromitsu Nakauchi
Hiromitsu Nakauchi Stanford University
Atsushi Iwama
Atsushi Iwama University of Tokyo
Ryozo Nagai
Ryozo Nagai Jichi Medical University
Sanford J. Shattil
Sanford J. Shattil University of California, San Diego
Takashi Kadowaki
Takashi Kadowaki Toranomon Hospital
Ichiro Manabe
Ichiro Manabe Chiba University
Fumihito Arai
Fumihito Arai University of Tokyo
Shinya Yamanaka
Shinya Yamanaka Kyoto University
Toshio Kitamura
Toshio Kitamura University of Tokyo
Gozoh Tsujimoto
Gozoh Tsujimoto Kyoto University

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