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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Molecular Biology

D-Index
121
Citations
62026
World Ranking
249
National Ranking
19

Medicine

D-Index
122
Citations
62809
World Ranking
3441
National Ranking
65

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Haruhiko Koseki is affiliated with the RIKEN Center for Integrative Medical Sciences in Japan. Their research spans multiple disciplines within the broader fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. The scientist has contributed extensively to subfields such as Molecular Biology, Immunology, Genetics, Cancer Research, and Hematology.

The primary focus areas in Koseki's research include:

  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • Acute Myeloid Leukemia Research
  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • Immune Cell Function and Interaction
  • Dermatology and Skin Diseases

Koseki has published in various scientific venues, with notable frequency in:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Blood
  • Journal of Investigative Dermatology

Some of their recent papers illustrate a wide range of molecular and genomic topics, including gene regulation mechanisms, epigenetic inheritance, immune cell function, and organoid biology. Selected recent publications include:

  • "Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release" (2021, Molecular Cell)
  • "Functional annotation of human long noncoding RNAs via molecular phenotyping" (2020, Genome Research)
  • "H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos" (2021, Nature Genetics)
  • "Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality" (2022, Glia)
  • "Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity" (2020, Nature Immunology)

In collaboration, Koseki frequently works with several other researchers, including Manabu Nakayama, Jafar Sharif, Osamu Ohara, Eiryo Kawakami, and Masayuki Amagai. These collaborations reflect shared interests in molecular biology, immunology, and related biomedical fields.

Best Publications

  • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

    Yukihiro Furusawa;Yuuki Obata;Shinji Fukuda;Takaho A. Endo

  • CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.

    Tetsu Kawano;Junqing Cui;Yasuhiko Koezuka;Isao Toura

  • Control of developmental regulators by Polycomb in human embryonic stem cells.

    Tong Ihn Lee;Richard G. Jenner;Laurie A. Boyer;Matthew G. Guenther

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Requirement for Vα14 NKT Cells in IL-12-Mediated Rejection of Tumors

    Junqing Cui;Tahiro Shin;Tetsu Kawano;Hiroshi Sato

  • The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

    Jafar Sharif;Masahiro Muto;Shin-ichiro Takebayashi;Isao Suetake

  • Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

    Manching Ku;Richard P. Koche;Richard P. Koche;Richard P. Koche;Esther Rheinbay;Esther Rheinbay;Esther Rheinbay;Eric M. Mendenhall;Eric M. Mendenhall

  • Polycomb Group Proteins Ring1A/B Link Ubiquitylation of Histone H2A to Heritable Gene Silencing and X Inactivation

    Mariana de Napoles;Jacqueline E. Mermoud;Rika Wakao;Y.Amy Tang

  • Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

    Neil P. Blackledge;Anca M. Farcas;Takashi Kondo;Hamish W. King

  • Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

    Julie K. Stock;Sara Giadrossi;Miguel Casanova;Emily Brookes

  • Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells

    Tetsu Kawano;Junqing Cui;Yasuhiko Koezuka;Isao Toura

  • Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

    Erik Arner;Carsten O. Daub;Kristoffer Vitting-Seerup;Robin Andersson

  • Enhanced self-renewal of hematopoietic stem cells mediated by the Polycomb gene product Bmi-1

    Atsushi Iwama;Hideyuki Oguro;Masamitsu Negishi;Yuko Kato

  • Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

    Tetsuya Fukuda;Takehiko Yoshida;Seiji Okada;Masahiko Hatano

  • Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1.

    Takashi Miki;Masashi Suzuki;Tadao Shibasaki;Hiroko Uemura

  • Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

    Stefan Schoeftner;Aditya K Sengupta;Stefan Kubicek;Karl Mechtler

  • Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.

    Yusuke Hirabayashi;Nao Suzki;Masafumi Tsuboi;Takaho A. Endo

  • PAX GENES AND ORGANOGENESIS

    Edgar Dahl;Haruhiko Koseki;Rudi Balling

  • KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas;Neil P Blackledge;Ian Sudbery;Hannah K Long;Hannah K Long

  • Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.

    Yumiko Saga;Naomi Hata;Haruhiko Koseki;Makoto M. Taketo

Frequent Co-Authors

Osamu Ohara
Osamu Ohara Chiba University
Atsushi Iwama
Atsushi Iwama University of Tokyo
Miguel Vidal
Miguel Vidal Spanish National Research Council
Hiroshi Kawamoto
Hiroshi Kawamoto Kyoto University
Toshinori Nakayama
Toshinori Nakayama Chiba University
Hiromitsu Nakauchi
Hiromitsu Nakauchi Stanford University
Neil Brockdorff
Neil Brockdorff University of Oxford

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