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Immunology

D-Index
63
Citations
15265
World Ranking
3008
National Ranking
1411

Overview

Mark A. Exley is affiliated with Brigham and Women's Hospital in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a substantial focus on subfields including Immunology, Oncology, Genetics, Biotechnology, and Biomedical Engineering.

Their work extensively covers topics such as CAR-T cell therapy research, Immune Cell Function and Interaction, Glioma Diagnosis and Treatment, Cancer Research and Treatments, Immunotherapy and Immune Responses, Cancer Immunotherapy and Biomarkers, and Nanoplatforms for cancer theranostics.

Mark A. Exley has contributed to numerous publications, including the following notable papers:

  • Phase Ib Clinical Trial of IGV-001 for Patients with Newly Diagnosed Glioblastoma, 2021, Clinical Cancer Research
  • A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome, 2024, Nature Communications
  • Exploiting CD1-restricted T cells for clinical benefit, 2021, Molecular Immunology
  • A biologic-device combination product delivering tumor-derived antigens elicits immunogenic cell death-associated immune responses against glioblastoma, 2023, Journal for ImmunoTherapy of Cancer
  • Challenges and Opportunities for Immunotherapeutic Intervention against Myeloid Immunosuppression in Glioblastoma, 2022, Journal of Clinical Medicine

The scientist frequently publishes in venues such as Regular and Young Investigator Award Abstracts, Cancer Research, Journal of Neuro-Oncology, Frontiers in Immunology, and Neuro-Oncology.

Frequent collaborators in their research include Jenny Zilberberg, Charles Scott, Christopher Uhl, David W. Andrews, and Christopher Cultrara.

Best Publications

  • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

    Ivan J. Fuss;Frank Heller;Monica Boirivant;Francisco Leon

  • Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

    S. Brian Wilson;Sally C. Kent;Kurt T. Patton;Tihamer Orban

  • Multiple immuno-regulatory defects in type-1 diabetes

    Anjli Kukreja;Giulia Cost;John Marker;Chenhui Zhang

  • Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells

    Mark Exley;Jorge A. Garcia;Steven P. Balk;Steven Porcelli

  • Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

    Lydia Lynch;Lydia Lynch;Michael Nowak;Bindu Varghese;Justice Clark

  • Loss of IFN-gamma production by invariant NK T cells in advanced cancer.

    S M Tahir;O Cheng;A Shaulov;Y Koezuka

  • Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

    Koh Hei Sonoda;Mark Exley;Scott Snapper;Steven P. Balk

  • Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

    Y N Naumov;K S Bahjat;R Gausling;R Abraham

  • CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung

    Edward E.S. Nieuwenhuis;Tetsuya Matsumoto;Mark Exley;Robbert A. Schleipman

  • NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance

    Koh-Hei Sonoda;Douglas E. Faunce;Masaru Taniguchi;Mark Exley

  • Efficacy of a therapeutic cocaine vaccine in rodent models

    Barbara S. Fox;Kathleen M. Kantak;Melissa A. Edwards;Kerry M. Black

  • CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains.

    Mark Exley;Steven Porcelli;Margo Furman;Jorge A. Garcia

  • Interplay between the immune system and adipose tissue in obesity.

    Mark Exley;Laura Elizabeth Hand;Donal O'Shea;Lydia Lynch

  • Activation of natural killer T cells by α-galactosylceramide in the presence of CD1d provides protection against colitis in mice

    Lawrence J. Saubermann;Paul Beck;Ype P. De Jong;Richard S. Pitman

  • Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line.

    P. Clapham;K. Nagy;R. Cheingsong-Popov;M. Exley

  • CD1d and invariant NKT cells at the human maternal-fetal interface.

    Jonathan E. Boyson;Basya Rybalov;Louise A. Koopman;Mark Exley

  • Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: receptor modulation and differentiation induced by phorbol ester.

    Paul R. Clapham;Robin A. Weiss;Angus G. Dalgleish;Mark Exley

  • CD1d structure and regulation on human thymocytes, peripheral blood T cells,B cells and monocytes

    M. Exley;Jorge A. Garcia;S. B. Wilson;F. Spada

  • Circulating Microparticles as Disease-Specific Biomarkers of Severity of Inflammation in Patients With Hepatitis C or Nonalcoholic Steatohepatitis

    Miroslaw Kornek;Michael Lynch;Shruti H. Mehta;Michelle Lai

  • Disseminated Varicella Infection Due to the Vaccine Strain of Varicella-Zoster Virus, in a Patient with a Novel Deficiency in Natural Killer T Cells

    Ofer Levy;Jordan S. Orange;Patricia Hibberd;Sharon Steinberg

  • CD1d function is regulated by microsomal triglyceride transfer protein.

    Suzana Brozovic;Takashi Nagaishi;Takashi Nagaishi;Masaru Yoshida;Masaru Yoshida;Stephanie Betz

Frequent Co-Authors

Steven P. Balk
Steven P. Balk Beth Israel Deaconess Medical Center
Richard S. Blumberg
Richard S. Blumberg Brigham and Women's Hospital
Lydia Lynch
Lydia Lynch Brigham and Women's Hospital
Steven A. Porcelli
Steven A. Porcelli Albert Einstein College of Medicine
Detlef Schuppan
Detlef Schuppan Johannes Gutenberg University of Mainz
Margaret James Koziel
Margaret James Koziel Harvard Medical School
Scott B. Snapper
Scott B. Snapper Boston Children's Hospital
Jack L. Strominger
Jack L. Strominger Harvard University

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