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Immunology

D-Index
57
Citations
11253
World Ranking
3632
National Ranking
167

Overview

Agnès Lehuen is affiliated with Université Paris Cité in France and has contributed extensively to research in immunology and related biomedical fields. Their work spans immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology, with significant contributions within the following subfields:

  • Immunology
  • Genetics
  • Physiology
  • Molecular Biology
  • Pathology and Forensic Medicine

The scientist's research primarily addresses key topics including:

  • Immune Cell Function and Interaction
  • Diabetes and associated disorders
  • T-cell and B-cell Immunology
  • Phagocytosis and Immune Regulation
  • Gut microbiota and health
  • Immunodeficiency and Autoimmune Disorders
  • Systemic Sclerosis and Related Diseases

Agnès Lehuen has authored several recent papers that focus on the role and regulation of mucosal-associated invariant T (MAIT) cells and their implications in metabolic dysfunction, inflammation, and infection. Selected publications include:

  • "Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity," 2021, Nature Immunology
  • "Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity," 2020, Nature Communications
  • "MAIT cells, guardians of skin and mucosa?," 2021, Mucosal Immunology
  • "Gut mucosa alterations and loss of segmented filamentous bacteria in type 1 diabetes are associated with inflammation rather than hyperglycaemia," 2021, Gut
  • "Prospective head-to-head comparison of non-invasive scores for diagnosis of fibrotic MASH in patients with type 2 diabetes," 2024, Journal of Hepatology

Frequently collaborating co-authors include:

  • Lucie Beaudoin
  • Amine Toubal
  • Léo Bertrand
  • Matthieu Rouland
  • Zouriatou Gouda

The work of Agnès Lehuen is regularly published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology
  • Journal of Hepatology
  • Molecular Immunology
  • Revue du Rhumatisme

Best Publications

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Activation of natural killer T cells by α -galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

    Shayan Sharif;Guillermo A. Arreaza;Peter Zucker;Qing-Sheng Mi

  • Immune cell crosstalk in type 1 diabetes

    Agnès Lehuen;Julien Diana;Paola Zaccone;Anne Cooke

  • Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

    Julien Diana;Julien Diana;Yannick Simoni;Yannick Simoni;Laetitia Furio;Laetitia Furio;Lucie Beaudoin;Lucie Beaudoin

  • Overexpression of Natural Killer T Cells Protects Vα14-Jα281 Transgenic Nonobese Diabetic Mice against Diabetes

    Agnès Lehuen;Olivier Lantz;Lucie Beaudoin;Véronique Laloux

  • Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients

    Isabelle Magalhaes;Karine Pingris;Christine Poitou;Stéphanie Bessoles

  • Fcα Receptor (Cd89) Mediates the Development of Immunoglobulin a (Iga) Nephropathy (Berger's Disease) Evidence for Pathogenic Soluble Receptor–Iga Complexes in Patients and Cd89 Transgenic Mice

    Pierre Launay;Béatrice Grossetête;Michelle Arcos-Fajardo;Emmanuelle Gaudin

  • Mucosal-associated invariant T cells and disease.

    Amine Toubal;Amine Toubal;Isabelle Nel;Isabelle Nel;Sophie Lotersztajn;Sophie Lotersztajn;Agnès Lehuen;Agnès Lehuen

  • Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice

    Karine Thébault-Baumont;Danielle Dubois-Laforgue;Patricia Krief;Jean-Paul Briand

  • Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

    Ophélie Rouxel;Ophélie Rouxel;Ophélie Rouxel;Jennifer Da Silva;Jennifer Da Silva;Jennifer Da Silva;Lucie Beaudoin;Lucie Beaudoin;Lucie Beaudoin;Isabelle Nel;Isabelle Nel;Isabelle Nel

  • NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic β cells

    Lucie Beaudoin;Véronique Laloux;Véronique Laloux;Jan Novak;Bruno Lucas;Bruno Lucas

  • Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes

    Datsen G. Wei;Hyunji Lee;Se Ho Park;Lucie Beaudoin

  • A Subset of Human Dendritic Cells Expresses IgA Fc Receptor (CD89), Which Mediates Internalization and Activation Upon Cross-Linking by IgA Complexes

    Frédéric Geissmann;Pierre Launay;Benoit Pasquier;Yves Lepelletier

  • Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity.

    Héloïse Flament;Héloïse Flament;Matthieu Rouland;Lucie Beaudoin;Amine Toubal

  • Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

    Pushpa Hegde;Pushpa Hegde;Emmanuel Weiss;Emmanuel Weiss;Valérie Paradis;Valérie Paradis;Jinghong Wan;Jinghong Wan

  • An embryonic source of Ly1 but not conventional B cells

    Nanette Solvason;Agnès Lehuen;John F. Kearney

  • Tolerance to Islet Antigens and Prevention from Diabetes Induced by Limited Apoptosis of Pancreatic β Cells

    Stéphanie Hugues;Evelyne Mougneau;Walter Ferlin;Dirk Jeske

  • IL-15 availability conditions homeostasis of peripheral natural killer T cells

    Thomas Ranson;Christian A. J. Vosshenrich;Erwan Corcuff;Odile Richard

  • NK T Cell-Induced Protection Against Diabetes in Vα14-Jα281 Transgenic Nonobese Diabetic Mice Is Associated with a Th2 Shift Circumscribed Regionally to the Islets and Functionally to Islet Autoantigen

    Véronique Laloux;Lucie Beaudoin;Dirk Jeske;Claude Carnaud

  • Cutting Edge: Vα14-Jα281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice

    Lennart T. Mars;Véronique Laloux;Karine Goude;Sabine Desbois

Frequent Co-Authors

Renato C. Monteiro
Renato C. Monteiro Université Paris Cité
Jamie Rossjohn
Jamie Rossjohn Monash University
Christian Boitard
Christian Boitard Université Paris Cité
Valérie Paradis
Valérie Paradis Université Paris Cité
Jean-François Bach
Jean-François Bach Grenoble Alpes University
Maria C. Leite-de-Moraes
Maria C. Leite-de-Moraes Centre national de la recherche scientifique, CNRS
Olivier Lantz
Olivier Lantz Institute Curie
Roland S. Liblau
Roland S. Liblau Federal University of Toulouse Midi-Pyrénées
James McCluskey
James McCluskey University of Melbourne
Ulrich Blank
Ulrich Blank Université Paris Cité

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Related Online Degrees & Career Pathways

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