Gerald S. Shadel spends much of his time researching Mitochondrion, Genetics, Cell biology, Mitochondrial DNA and Reactive oxygen species. His study in Mitochondrion focuses on Mitochondrial ROS in particular. His Cell biology study incorporates themes from Tube formation and Cellular differentiation.
Gerald S. Shadel combines subjects such as Molecular biology, DNA replication factor CDT1, Eukaryotic DNA replication and Replication protein A with his study of Mitochondrial DNA. His research in Reactive oxygen species tackles topics such as Oxidative phosphorylation which are related to areas like Homeostasis and Cell signaling. His research in Innate immune system intersects with topics in Interferon and Immunity.
Gerald S. Shadel mostly deals with Mitochondrion, Cell biology, Mitochondrial DNA, Genetics and Transcription. His Mitochondrion research integrates issues from Oxidative stress and Reactive oxygen species. His Cell biology research is multidisciplinary, incorporating elements of Cell, Innate immune system and Transcription factor.
His biological study spans a wide range of topics, including Molecular biology and Oxidative phosphorylation. Gerald S. Shadel combines subjects such as Promoter, TFAM and DNA damage with his study of Molecular biology. In general Transcription, his work in Operon and Mitochondrial transcription is often linked to Autoinducer linking many areas of study.
His main research concerns Mitochondrion, Cell biology, Mitochondrial DNA, Innate immune system and Cancer research. Mitochondrion is a primary field of his research addressed under Biochemistry. His research integrates issues of Cancer cell, Gene expression and DNA in his study of Cell biology.
His Mitochondrial DNA study deals with the bigger picture of Genetics. Gerald S. Shadel has researched Innate immune system in several fields, including Cancer and Interferon. His Cancer research research incorporates themes from ATP5B and Immune system, Immunotherapy.
Gerald S. Shadel mainly investigates Mitochondrion, Innate immune system, Immune system, Mitochondrial DNA and Immunology. His study on Mitochondrion is covered under Cell biology. As a part of the same scientific study, he usually deals with the Cell biology, concentrating on Oxidative phosphorylation and frequently concerns with Signal transduction.
His research in the fields of Immunotherapy overlaps with other disciplines such as Sting. His studies examine the connections between Mitochondrial DNA and genetics, as well as such issues in Interferon, with regards to Pathology, Receptor, Pattern recognition receptor, Immunity and Extracellular. His work carried out in the field of Immunology brings together such families of science as Apoptosis and COPD.
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TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
A. Phillip West;Igor E. Brodsky;Igor E. Brodsky;Christoph Rahner;Dong Kyun Woo.
Nature (2011)
Mitochondrial DNA maintenance in vertebrates.
Gerald S. Shadel;David A. Clayton.
Annual Review of Biochemistry (1997)
Mitochondria in innate immune responses
A. Phillip West;Gerald S. Shadel;Sankar Ghosh.
Nature Reviews Immunology (2011)
Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response
A. Phillip West;William Khoury-Hanold;Matthew Staron;Michal C. Tal.
Nature (2015)
Mitochondrial ROS Signaling in Organismal Homeostasis
Gerald S. Shadel;Tamas L. Horvath.
Cell (2015)
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
Michal Caspi Tal;Miwa Sasai;Heung Kyu Lee;Brian Yordy.
Proceedings of the National Academy of Sciences of the United States of America (2009)
Replicative and Chronological Aging in Saccharomyces cerevisiae
Valter D. Longo;Gerald S. Shadel;Matt Kaeberlein;Matt Kaeberlein;Brian Kennedy;Brian Kennedy.
Cell Metabolism (2012)
Mitochondrial DNA in innate immune responses and inflammatory pathology
A. Phillip West;Gerald S. Shadel.
Nature Reviews Immunology (2017)
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Anthony Rongvaux;Ruaidhrí Jackson;Christian C D Harman;Tuo Li.
Cell (2014)
Interventions to Slow Aging in Humans: Are We Ready?
Valter D. Longo;Adam Antebi;Andrzej Bartke;Nir Barzilai.
Aging Cell (2015)
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