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Molecular Biology

D-Index
84
Citations
27716
World Ranking
873
National Ranking
460

Overview

Gerald S. Shadel is affiliated with the Salk Institute for Biological Studies in the United States. Their research spans multiple fields with a strong focus on biochemistry, genetics, molecular biology, medicine, immunology, and microbiology.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Immunology and Microbiology

Subfields of particular focus are:

  • Molecular Biology
  • Immunology
  • Epidemiology
  • Cell Biology
  • Infectious Diseases

Shadel's research topics show a specialization in immune system functioning and mitochondrial biology. Key research themes include:

  • Interferon and immune responses
  • Mitochondrial Function and Pathology
  • Inflammasome and immune disorders
  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer
  • Cytomegalovirus and herpesvirus research
  • Epigenetics and DNA Methylation

The scientist has published in several prominent venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Science
  • Immunity
  • Cell

Recent significant papers include:

  • "Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling" (2022, Immunity)
  • "SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2" (2021, Circulation Research)
  • "Apoptotic stress causes mtDNA release during senescence and drives the SASP" (2023, Nature)
  • "Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity" (2023, Cell)
  • "Mitochondrial DNA Release in Innate Immune Signaling" (2023, Annual Review of Biochemistry)

Frequent co-authors who have collaborated with Shadel include:

  • Uri Manor
  • Gladys R. Rojas
  • Cara R. Schiavon
  • Alva G. Sainz
  • Laura Newman

Best Publications

  • Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response

    A. Phillip West;William Khoury-Hanold;Matthew Staron;Michal C. Tal

  • TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

    A. Phillip West;Igor E. Brodsky;Igor E. Brodsky;Christoph Rahner;Dong Kyun Woo

  • Mitochondria in innate immune responses

    A. Phillip West;Gerald S. Shadel;Sankar Ghosh

  • Mitochondrial DNA maintenance in vertebrates.

    Gerald S. Shadel;David A. Clayton

  • Mitochondrial ROS Signaling in Organismal Homeostasis

    Gerald S. Shadel;Tamas L. Horvath

  • Mitochondrial DNA in innate immune responses and inflammatory pathology

    A. Phillip West;Gerald S. Shadel

  • Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

    Anthony Rongvaux;Ruaidhrí Jackson;Christian C D Harman;Tuo Li

  • Replicative and Chronological Aging in Saccharomyces cerevisiae

    Valter D. Longo;Gerald S. Shadel;Matt Kaeberlein;Matt Kaeberlein;Brian Kennedy;Brian Kennedy

  • Interventions to Slow Aging in Humans: Are We Ready?

    Valter D. Longo;Adam Antebi;Andrzej Bartke;Nir Barzilai

  • Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

    Michal Caspi Tal;Miwa Sasai;Heung Kyu Lee;Brian Yordy

  • Reduced TOR Signaling Extends Chronological Life Span via Increased Respiration and Upregulation of Mitochondrial Gene Expression

    Nicholas D. Bonawitz;Marc Chatenay-Lapointe;Yong Pan;Gerald S. Shadel

  • SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.

    Yuyang Lei;Jiao Zhang;Jiao Zhang;Cara R. Schiavon;Ming He

  • Initiation and beyond: multiple functions of the human mitochondrial transcription machinery.

    Nicholas D. Bonawitz;David A. Clayton;Gerald S. Shadel

  • Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

    Hui Young Lee;Cheol Soo Choi;Cheol Soo Choi;Andreas L. Birkenfeld;Tiago C. Alves

  • Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

    Yong Pan;Elizabeth A. Schroeder;Alejandro Ocampo;Antoni Barrientos

  • Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

    Michal Harel;Rona Ortenberg;Rona Ortenberg;Siva Karthik Varanasi;Kailash Chandra Mangalhara

  • Identification of the operator of the lux regulon from the Vibrio fischeri strain ATCC7744.

    Jerry H. Devine;Gerald S. Shadel;Thomas O. Baldwin

  • Revisiting the TCA cycle: signaling to tumor formation

    Nuno Raimundo;Bora E. Baysal;Gerald S. Shadel

  • A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine.

    Vicki McCulloch;Bonnie L. Seidel-Rogol;Gerald S. Shadel

  • Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis.

    Maria A. Lebedeva;Jana S. Eaton;Jana S. Eaton;Gerald S. Shadel

Frequent Co-Authors

David A. Clayton
David A. Clayton Howard Hughes Medical Institute
Susan M. Kaech
Susan M. Kaech Salk Institute for Biological Studies
Thomas O. Baldwin
Thomas O. Baldwin University of California, Riverside
Akiko Iwasaki
Akiko Iwasaki Yale University
Craig E. Cameron
Craig E. Cameron University of North Carolina at Chapel Hill
Paul W. Doetsch
Paul W. Doetsch National Institute of Environmental Health Sciences
Brian K. Kennedy
Brian K. Kennedy National University of Singapore
William C. Sessa
William C. Sessa Pfizer (United States)
Qin Yan
Qin Yan Yale University
David A. Sinclair
David A. Sinclair Harvard University

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