D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Molecular Biology D-index 73 Citations 19,570 142 World Ranking 782 National Ranking 432

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Genetics

Gerald S. Shadel spends much of his time researching Mitochondrion, Genetics, Cell biology, Mitochondrial DNA and Reactive oxygen species. His study in Mitochondrion focuses on Mitochondrial ROS in particular. His Cell biology study incorporates themes from Tube formation and Cellular differentiation.

Gerald S. Shadel combines subjects such as Molecular biology, DNA replication factor CDT1, Eukaryotic DNA replication and Replication protein A with his study of Mitochondrial DNA. His research in Reactive oxygen species tackles topics such as Oxidative phosphorylation which are related to areas like Homeostasis and Cell signaling. His research in Innate immune system intersects with topics in Interferon and Immunity.

His most cited work include:

  • TLR signalling augments macrophage bactericidal activity through mitochondrial ROS (884 citations)
  • Mitochondrial DNA maintenance in vertebrates. (870 citations)
  • Mitochondria in innate immune responses (741 citations)

What are the main themes of his work throughout his whole career to date?

Gerald S. Shadel mostly deals with Mitochondrion, Cell biology, Mitochondrial DNA, Genetics and Transcription. His Mitochondrion research integrates issues from Oxidative stress and Reactive oxygen species. His Cell biology research is multidisciplinary, incorporating elements of Cell, Innate immune system and Transcription factor.

His biological study spans a wide range of topics, including Molecular biology and Oxidative phosphorylation. Gerald S. Shadel combines subjects such as Promoter, TFAM and DNA damage with his study of Molecular biology. In general Transcription, his work in Operon and Mitochondrial transcription is often linked to Autoinducer linking many areas of study.

He most often published in these fields:

  • Mitochondrion (45.52%)
  • Cell biology (41.38%)
  • Mitochondrial DNA (33.79%)

What were the highlights of his more recent work (between 2014-2021)?

  • Mitochondrion (45.52%)
  • Cell biology (41.38%)
  • Mitochondrial DNA (33.79%)

In recent papers he was focusing on the following fields of study:

His main research concerns Mitochondrion, Cell biology, Mitochondrial DNA, Innate immune system and Cancer research. Mitochondrion is a primary field of his research addressed under Biochemistry. His research integrates issues of Cancer cell, Gene expression and DNA in his study of Cell biology.

His Mitochondrial DNA study deals with the bigger picture of Genetics. Gerald S. Shadel has researched Innate immune system in several fields, including Cancer and Interferon. His Cancer research research incorporates themes from ATP5B and Immune system, Immunotherapy.

Between 2014 and 2021, his most popular works were:

  • Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response (645 citations)
  • Mitochondrial ROS Signaling in Organismal Homeostasis (460 citations)
  • Interventions to Slow Aging in Humans: Are We Ready? (307 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Genetics

Gerald S. Shadel mainly investigates Mitochondrion, Innate immune system, Immune system, Mitochondrial DNA and Immunology. His study on Mitochondrion is covered under Cell biology. As a part of the same scientific study, he usually deals with the Cell biology, concentrating on Oxidative phosphorylation and frequently concerns with Signal transduction.

His research in the fields of Immunotherapy overlaps with other disciplines such as Sting. His studies examine the connections between Mitochondrial DNA and genetics, as well as such issues in Interferon, with regards to Pathology, Receptor, Pattern recognition receptor, Immunity and Extracellular. His work carried out in the field of Immunology brings together such families of science as Apoptosis and COPD.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

A. Phillip West;Igor E. Brodsky;Igor E. Brodsky;Christoph Rahner;Dong Kyun Woo.
Nature (2011)

1350 Citations

Mitochondrial DNA maintenance in vertebrates.

Gerald S. Shadel;David A. Clayton.
Annual Review of Biochemistry (1997)

1237 Citations

Mitochondria in innate immune responses

A. Phillip West;Gerald S. Shadel;Sankar Ghosh.
Nature Reviews Immunology (2011)

1173 Citations

Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response

A. Phillip West;William Khoury-Hanold;Matthew Staron;Michal C. Tal.
Nature (2015)

1081 Citations

Mitochondrial ROS Signaling in Organismal Homeostasis

Gerald S. Shadel;Tamas L. Horvath.
Cell (2015)

823 Citations

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

Michal Caspi Tal;Miwa Sasai;Heung Kyu Lee;Brian Yordy.
Proceedings of the National Academy of Sciences of the United States of America (2009)

586 Citations

Replicative and Chronological Aging in Saccharomyces cerevisiae

Valter D. Longo;Gerald S. Shadel;Matt Kaeberlein;Matt Kaeberlein;Brian Kennedy;Brian Kennedy.
Cell Metabolism (2012)

568 Citations

Mitochondrial DNA in innate immune responses and inflammatory pathology

A. Phillip West;Gerald S. Shadel.
Nature Reviews Immunology (2017)

555 Citations

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Anthony Rongvaux;Ruaidhrí Jackson;Christian C D Harman;Tuo Li.
Cell (2014)

554 Citations

Interventions to Slow Aging in Humans: Are We Ready?

Valter D. Longo;Adam Antebi;Andrzej Bartke;Nir Barzilai.
Aging Cell (2015)

503 Citations

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