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D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
20875
World Ranking
14152
National Ranking
261

Overview

Pius Loetscher is affiliated with Novartis in Switzerland, contributing to research primarily in the fields of medicine and biochemistry, genetics, and molecular biology. Their work spans several subfields, including molecular biology, immunology, physiology, rheumatology, and epidemiology.

The scientist focuses on topics related to immune response and inflammation, systemic lupus erythematosus research, asthma and respiratory diseases, nitric oxide and endothelin effects, ion transport and channel regulation, receptor mechanisms and signaling, as well as immunotherapy and immune responses.

Recent publications by Pius Loetscher include:

  • The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells, 2020, iScience
  • Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy, 2023, Cell Reports Medicine
  • Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase, 2021, Journal of Medicinal Chemistry
  • Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay, 2020, Journal of Medicinal Chemistry
  • Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist, 2022, ACS Medicinal Chemistry Letters

Frequent co-authors collaborating with Pius Loetscher include Stuart Hawtin, Claudia Betschart, Roland Feifel, Tobias Junt, and Thomas Boulay.

Publication venues most commonly featuring Pius Loetscher's work are:

  • Journal of Medicinal Chemistry
  • iScience
  • Cell Reports Medicine
  • ACS Medicinal Chemistry Letters
  • Annals of the Rheumatic Diseases

Best Publications

  • Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

    Patrick Schaerli;Katharina Willimann;Alois B. Lang;Martin Lipp

  • Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

    Federica Sallusto;Patrick Schaerli;Pius Loetscher;Christoph Schaniel

  • Lymphocyte traffic control by chemokines.

    Bernhard Moser;Pius Loetscher

  • Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

    M Loetscher;B Gerber;P Loetscher;S A Jones

  • CCR5 is characteristic of Th1 lymphocytes

    Pius Loetscher;Mariagrazia Uguccioni;Lorenza Bordoli;Marco Baggiolini

  • Chemokines: multiple levels of leukocyte migration control☆ ☆

    Bernhard Moser;Marlene Wolf;Alfred Walz;Pius Loetscher

  • Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

    Matthew P. Crump;Jiang Hong Gong;Pius Loetscher;Krishna Rajarathnam

  • HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication

    Ali Amara;Sylvie Le Gall;Olivier Schwartz;Jean Salamero

  • High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

    Mariagrazia Uguccioni;Charles R. Mackay;Brigitte Ochensberger;Pius Loetscher

  • Interleukin-8 and the chemokine family.

    Marco Baggiolini;Pius Loetscher;Bernhard Moser

  • Eotaxin-2, a Novel CC Chemokine that Is Selective for the Chemokine Receptor CCR3, and Acts Like Eotaxin on Human Eosinophil and Basophil Leukocytes

    Ulf Forssmann;Mariagrazia Uguccioni;Pius Loetscher;Clemens A. Dahinden

  • Lymphocyte‐specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization

    Marcel Loetscher;Pius Loetscher;Nicole Brass;Eckart Meese

  • Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes.

    P Loetscher;M Seitz;I Clark-Lewis;M Baggiolini

  • Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release.

    P Loetscher;M Seitz;I Clark-Lewis;M Baggiolini

  • The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.

    Pius Loetscher;Antonio Pellegrino;Jiang-Hong Gong;Ivan Mattioli

  • HIV blocked by chemokine antagonist

    Fernando Arenzana-Seisdedos;Jean-Louis Virelizier;Dominique Rousset;Ian Clark-Lewis

  • Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes.

    Bettina Tilton;Liza Ho;Estelle Oberlin;Pius Loetscher

  • Chemokines in inflammation and immunity

    Marco Baggiolini;Pius Loetscher

  • A randomized controlled trial with an anti-CCL2 (anti–monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis

    Jasper J. Haringman;Danielle M. Gerlag;Tom J. M. Smeets;Dominique Baeten;Dominique Baeten

  • Chemokines and their receptors in lymphocyte traffic and HIV infection.

    Pius Loetscher;Bernhard Moser;Marco Baggiolini

Frequent Co-Authors

Marco Baggiolini
Marco Baggiolini University of Bern
Bernhard Moser
Bernhard Moser Cardiff University
Mariagrazia Uguccioni
Mariagrazia Uguccioni Universita della Svizzera Italiana
Beatrice Dewald
Beatrice Dewald University of Bern
Ian Clark-Lewis
Ian Clark-Lewis University of British Columbia
Fernando Arenzana-Seisdedos
Fernando Arenzana-Seisdedos Chinese Academy of Sciences
Marcus Thelen
Marcus Thelen Universita della Svizzera Italiana
Ali Amara
Ali Amara Université Paris Cité
Jean-Louis Virelizier
Jean-Louis Virelizier Institut Pasteur
Simon Arnett Jones
Simon Arnett Jones Cardiff University

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