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D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
19880
World Ranking
8522
National Ranking
151

Overview

Marcus Thelen is affiliated with the Universita della Svizzera Italiana in Switzerland. Their research focuses primarily on the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Key subfields include Immunology, Oncology, Molecular Biology, Biophysics, and Infectious Diseases.

Thelen's scientific contributions emphasize several topics related to immune system functioning and cellular signaling, such as:

  • Chemokine receptors and signaling
  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • Cell Image Analysis Techniques
  • Receptor Mechanisms and Signaling
  • Image Processing Techniques and Applications
  • COVID-19 Clinical Research Studies

Recent papers authored or co-authored by Thelen showcase investigations in immunology and cell biology, including:

  • Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course (2023, Nature Immunology)
  • B cell zone reticular cell microenvironments shape CXCL13 gradient formation (2020, Nature Communications)
  • PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation (2021, Science)
  • ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins (2020, Frontiers in Immunology)
  • CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4 (2020, Journal of Leukocyte Biology)

Thelen's frequent collaborators include researchers with whom multiple publications have been produced, notably:

  • Daniel F. Legler
  • Mariagrazia Uguccioni
  • Paola Antonello
  • Diego Ulisse Pizzagalli
  • Sylvia Thelen

Thelen has published extensively in certain scientific journals and platforms, reflecting their active involvement in specific publication venues:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • IUPHAR/BPS Guide to Pharmacology CITE
  • Zenodo (CERN European Organization for Nuclear Research)
  • eLife

Best Publications

  • The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.

    Karl Balabanian;Bernard Lagane;Simona Infantino;Ken Y.C. Chow

  • International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors

    Francoise Bachelerie;Adit Ben-Baruch;Amanda M. Burkhardt;Christophe Combadiere

  • MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin.

    J. H. Hartwig;M. Thelen;M. Thelen;A. Resen;P. A. Janmey

  • Dancing to the tune of chemokines.

    Marcus Thelen

  • HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

    Milena Schiraldi;Angela Raucci;Laura Martínez Muñoz;Elsa Livoti

  • GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism.

    Thorsten Laux;Kiyoko Fukami;Marcus Thelen;Tamara Golub

  • The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

    L.R Stephens;A Eguinoa;H Erdjument-Bromage;M Lui

  • CXCR7 functions as a scavenger for CXCL12 and CXCL11.

    Ulrike Naumann;Elisabetta Cameroni;Monika Pruenster;Harsha Mahabaleshwar

  • Eotaxin-2, a Novel CC Chemokine that Is Selective for the Chemokine Receptor CCR3, and Acts Like Eotaxin on Human Eosinophil and Basophil Leukocytes

    Ulf Forssmann;Mariagrazia Uguccioni;Pius Loetscher;Clemens A. Dahinden

  • Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane.

    Marcus Thelen;Antony Rosen;Angus C. Nairn;Alan Aderem

  • How chemokines invite leukocytes to dance

    Marcus Thelen;Jens V Stein

  • Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine.

    Ali Amara;Olivier Lorthioir;Agustin Valenzuela;Aude Magerus

  • Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist.

    Marcus Thelen;Paola Peveri;Peter Kernen;Vinzenz Von Tscharner

  • Neutrophil signal transduction and activation of the respiratory burst

    M. Thelen;B. Dewald;M. Baggiolini

  • Carboxyl-Terminal Modulator Protein (CTMP), a Negative Regulator of PKB/Akt and v-Akt at the Plasma Membrane

    Sauveur-Michel Maira;Ivana Galetic;Derek P. Brazil;Stefanie Kaech

  • Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes.

    Bettina Tilton;Liza Ho;Estelle Oberlin;Pius Loetscher

  • CXCR7, CXCR4 and CXCL12: an eccentric trio?

    Marcus Thelen;Sylvia Thelen

  • Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor.

    I Lindley;H Aschauer;J M Seifert;C Lam

  • A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12‐triggered integrin activation but not in chemokine‐triggered motility of human T lymphocytes and CD34+ cells

    Tanja Nicole Hartmann;Tanja Nicole Hartmann;Valentin Grabovsky;Ronit Pasvolsky;Ziv Shulman

  • Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

    Marcus Thelen;Matthias P. Wymann;Hanno Langen

Frequent Co-Authors

Marco Baggiolini
Marco Baggiolini University of Bern
Mariagrazia Uguccioni
Mariagrazia Uguccioni Universita della Svizzera Italiana
Angelo Azzi
Angelo Azzi Tufts University
Antal Rot
Antal Rot Queen Mary University of London
Beatrice Dewald
Beatrice Dewald University of Bern
Massimo Locati
Massimo Locati University of Milan
Alberto Mantovani
Alberto Mantovani Humanitas University
Gerard J. Graham
Gerard J. Graham University of Glasgow
Françoise Bachelerie
Françoise Bachelerie University of Paris-Saclay
Silvano Sozzani
Silvano Sozzani Sapienza University of Rome

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