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Massimo Locati

Massimo Locati

D-Index & Metrics

Immunology

D-Index
87
Citations
56080
World Ranking
1187
National Ranking
45

Overview

Massimo Locati is affiliated with the University of Milan in Italy and has a substantial body of research primarily in the fields of Medicine and Immunology and Microbiology. Their work covers both broad and specialized topics, contributing to 60 publications in Medicine and 37 in Immunology and Microbiology.

Their research encompasses multiple subfields, including Immunology, Oncology, Molecular Biology, Genetics, and Immunology and Allergy. These represent critical areas within biomedical research and reflect an interdisciplinary approach to the study of disease mechanisms and immune function.

Main topics addressed by Locati include:

  • Chemokine receptors and signaling
  • Immune cells in cancer
  • Cell Adhesion Molecules Research
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • Genomics, phytochemicals, and oxidative stress
  • Cancer Immunotherapy and Biomarkers

Frequent co-authors in Locati's work include:

  • Samantha Milanesi
  • Alessandra Castagna
  • Alberto Mantovani
  • Raffaella Bonecchi
  • Elena Monica Borroni

Locati's publications appear consistently in a variety of reputable venues. Notable publication venues where multiple works have appeared include:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Frontiers in Immunology
  • IUPHAR/BPS Guide to Pharmacology CITE
  • Cancer Research
  • Vaccines

Representative recent papers by Locati include:

  • "The tetraspan MS4A family in homeostasis, immunity, and disease" (2021), published in Trends in Immunology
  • "Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial" (2020), published in EBioMedicine
  • "Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions" (2021), published in Journal of Leukocyte Biology
  • "Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context" (2022), published in Nature Communications
  • "ACKR2 contributes to pulmonary dysfunction by shaping CCL5:CCR5-dependent recruitment of lymphocytes during influenza A infection in mice" (2020), published in American Journal of Physiology-Lung Cellular and Molecular Physiology

Through a multidisciplinary lens, Locati investigates immune cell behavior, signaling pathways, and disease pathogenesis, particularly focusing on the interplay between chemokine receptors and tumor biology.

Best Publications

  • The chemokine system in diverse forms of macrophage activation and polarization.

    Alberto Mantovani;Alberto Mantovani;Antonio Sica;Silvano Sozzani;Silvano Sozzani;Paola Allavena

  • Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

    Alberto Mantovani;Silvano Sozzani;Silvano Sozzani;Massimo Locati;Paola Allavena

  • Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

    Peter J Murray;Judith E Allen;Subhra K Biswas;Edward A Fisher

  • Macrophage activation and polarization.

    Fernando Oneissi Martinez;Antonio Sica;Alberto Mantovani;Massimo Locati

  • Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

    Fernando O. Martinez;Siamon Gordon;Massimo Locati;Alberto Mantovani

  • Macrophage plasticity and polarization in tissue repair and remodelling.

    Alberto Mantovani;Subhra K Biswas;Maria Rosaria Galdiero;Antonio Sica

  • Diversity, Mechanisms, and Significance of Macrophage Plasticity

    Massimo Locati;Graziella Curtale;Alberto Mantovani;Alberto Mantovani

  • Macrophage Polarization Comes of Age

    Alberto Mantovani;Antonio Sica;Massimo Locati

  • International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors

    Francoise Bachelerie;Adit Ben-Baruch;Amanda M. Burkhardt;Christophe Combadiere

  • Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals.

    Flavia Bazzoni;Marzia Rossato;Marco Fabbri;Daniele Gaudiosi

  • Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

    Fernando O. Martinez;Laura Helming;Ronny Milde;Audrey Varin

  • Tuning inflammation and immunity by chemokine sequestration: decoys and more

    Alberto Mantovani;Raffaella Bonecchi;Massimo Locati

  • New vistas on macrophage differentiation and activation.

    Alberto Mantovani;Antonio Sica;Massimo Locati

  • Macrophage Diversity and Polarization in Atherosclerosis. A Question of Balance

    Alberto Mantovani;Cecilia Garlanda;Massimo Locati

  • Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines

    Alberto Mantovani;Massimo Locati;Annunciata Vecchi;Silvano Sozzani

  • The chemokine system in cancer biology and therapy

    Alberto Mantovani;Benedetta Savino;Massimo Locati;Luca Zammataro

  • Differential regulation of iron homeostasis during human macrophage polarized activation.

    Stefania Recalcati;Massimo Locati;Agnese Marini;Paolo Santambrogio

  • Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity

    Massimo Locati;Alberto Mantovani;Antonio Sica;Antonio Sica

  • Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation.

    Alberto Mantovani;Antonio Sica;Paola Allavena;Cecilia Garlanda

  • Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury

    Riccardo Bertini;Marcello Allegretti;Cinzia Bizzarri;Alessio Moriconi

Frequent Co-Authors

Alberto Mantovani
Alberto Mantovani Humanitas University
Silvano Sozzani
Silvano Sozzani Sapienza University of Rome
Raffaella Bonecchi
Raffaella Bonecchi Humanitas University
Annunciata Vecchi
Annunciata Vecchi Mario Negri Institute for Pharmacological Research
Paola Allavena
Paola Allavena Humanitas University
Antonio Sica
Antonio Sica University of Eastern Piedmont Amadeo Avogadro
Marina Sironi
Marina Sironi Humanitas University
Philip M. Murphy
Philip M. Murphy National Institutes of Health
Bodduluri Haribabu
Bodduluri Haribabu University of Louisville
Mauro M. Teixeira
Mauro M. Teixeira Universidade Federal de Minas Gerais

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