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Raffaella Bonecchi

Raffaella Bonecchi

D-Index & Metrics

Immunology

D-Index
42
Citations
13063
World Ranking
4865
National Ranking
214

Overview

Raffaella Bonecchi is affiliated with Humanitas University in Italy and conducts research primarily in the fields of Immunology and Microbiology as well as Medicine. Their work extensively covers Immunology, Oncology, Immunology and Allergy, Genetics, and Molecular Biology.

The main topics investigated by Bonecchi include:

  • Chemokine receptors and signaling
  • Immune cells in cancer
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Cell Adhesion Molecules Research
  • Glioma Diagnosis and Treatment
  • Immune Response and Inflammation
  • Immunotherapy and Immune Responses

Among Bonecchi's recent papers are:

  • "Neutrophil diversity and plasticity in tumour progression and therapy," 2020, Nature reviews. Cancer
  • "Multiple Roles for Chemokines in Neutrophil Biology," 2020, Frontiers in Immunology
  • "Chemokines as Regulators of Neutrophils: Focus on Tumors, Therapeutic Targeting, and Immunotherapy," 2022, Cancers
  • "CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer," 2023, Cancer Immunology Research
  • "Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a CXCR4Leu317fsX3 mutation causing WHIM syndrome," 2023, JCI Insight

Frequent collaborators in Bonecchi's research include Massimo Locati, Benedetta Savino, Samantha Milanesi, Alessandra Castagna, and Matteo Simonelli.

Bonecchi has published regularly in several scientific venues, notably:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Frontiers in Immunology
  • Nature reviews. Cancer
  • Cancers
  • Cancer Immunology Research

The research focus involves detailed exploration of chemokine signaling pathways and their role in immune cell dynamics within cancer biology. Bonecchi's work also delves into neutrophil biology, tumor microenvironment interactions, and mechanisms of immune response modulation, contributing to areas related to immunotherapy strategies and inflammation.

Best Publications

  • Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

    Raffaella Bonecchi;Giancarlo Bianchi;Paola Panina Bordignon;Daniele D'Ambrosio

  • Neutrophil diversity and plasticity in tumour progression and therapy.

    Sebastien Jaillon;Andrea Ponzetta;Diletta Di Mitri;Angela Santoni

  • Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties.

    Silvano Sozzani;Paola Allavena;Giovanna D’Amico;Walter Luini

  • Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells

    Daniele D’Ambrosio;Andrea Iellem;Raffaella Bonecchi;Daniela Mazzeo

  • Tuning inflammation and immunity by chemokine sequestration: decoys and more

    Alberto Mantovani;Raffaella Bonecchi;Massimo Locati

  • Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy.

    Valeria Mollica Poeta;Matteo Massara;Arianna Capucetti;Raffaella Bonecchi

  • The chemokine system in cancer biology and therapy

    Alberto Mantovani;Benedetta Savino;Massimo Locati;Luca Zammataro

  • Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas.

    William Vermi;Raffaella Bonecchi;Fabio Facchetti;Denise Bianchi

  • Chemokines and chemokine receptors: an overview.

    Raffaella Bonecchi;Emanuela Galliera;Elena Monica Borroni;Massimiliano Marco Corsi

  • Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.

    Marisa Vulcano;Cristina Albanesi;Antonella Stoppacciaro;Renzo Bagnati

  • Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-γ in human neutrophils

    Raffaella Bonecchi;Nadia Polentarutti;Walter Luini;Alessandro Borsatti

  • Divergent Effects of Interleukin-4 and Interferon-γ on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses

    Raffaella Bonecchi;Silvano Sozzani;Silvano Sozzani;Silvano Sozzani;Johnny T. Stine;Johnny T. Stine;Johnny T. Stine;Walter Luini;Walter Luini;Walter Luini

  • Multiple Roles for Chemokines in Neutrophil Biology

    Arianna Capucetti;Francesca Albano;Raffaella Bonecchi

  • Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response

    Raffaella Bonecchi;Gerard J. Graham

  • The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

    Stefania Vetrano;Elena M Borroni;Adelaida Sarukhan;Benedetta Savino

  • Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells

    Annunciata Vecchi;Lucia Massimiliano;Simona Ramponi;Walter Luini

  • β-Arrestin-dependent Constitutive Internalization of the Human Chemokine Decoy Receptor D6

    Emanuela Galliera;Venkatakrishna R. Jala;John O. Trent;Raffaaella Bonecchi

  • Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6

    Yeny Martinez de la Torre;Chiara Buracchi;Elena M. Borroni;Jana Dupor

  • Unique regulation of CCL18 production by maturing dendritic cells.

    Marisa Vulcano;Sofie Struyf;Patrizia Scapini;Marco Cassatella

  • Induction of Functional IL-8 Receptors by IL-4 and IL-13 in Human Monocytes

    Raffaella Bonecchi;Fabio Facchetti;Stefano Dusi;Walter Luini

Frequent Co-Authors

Massimo Locati
Massimo Locati University of Milan
Alberto Mantovani
Alberto Mantovani Humanitas University
Silvano Sozzani
Silvano Sozzani Sapienza University of Rome
Paola Allavena
Paola Allavena Humanitas University
Annunciata Vecchi
Annunciata Vecchi Mario Negri Institute for Pharmacological Research
Bodduluri Haribabu
Bodduluri Haribabu University of Louisville
Sofie Struyf
Sofie Struyf KU Leuven
Andrea Doni
Andrea Doni Humanitas Research Hospital
Marina Sironi
Marina Sironi Humanitas University
Massimo Fantini
Massimo Fantini Precision Biologics

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