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Paul Proost

Paul Proost

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
112
Citations
35739
World Ranking
915
National Ranking
14

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Paul Proost is affiliated with KU Leuven in Belgium and has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research spans a variety of subfields, including Immunology, Molecular Biology, Oncology, Infectious Diseases, and Immunology and Allergy.

The main topics Paul Proost has worked on encompass:

  • Chemokine receptors and signaling
  • Immune Response and Inflammation
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • COVID-19 Clinical Research Studies
  • Protease and Inhibitor Mechanisms
  • Cell Adhesion Molecules Research
  • Long-Term Effects of COVID-19

Their publication record includes research articles in frequent venues such as:

  • Frontiers in Immunology
  • International Journal of Molecular Sciences
  • Cellular and Molecular Life Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Arthritis & Rheumatology

Several recent papers by Paul Proost include:

  • Neutrophil chemoattractant receptors in health and disease: double-edged swords, 2020, Cellular and Molecular Immunology
  • The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention, 2023, Cellular and Molecular Immunology
  • Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages, 2021, Cell Research
  • Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity, 2021, Nature Communications
  • Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis, 2021, Frontiers in Cell and Developmental Biology

Collaborative work is a notable aspect of Paul Proost's research, with frequent coauthors including:

  • Mieke Gouwy
  • Sofie Struyf
  • Mieke Metzemaekers
  • Patrick Matthys
  • Carine Wouters

Best Publications

  • Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact

    Philippe Van den Steen;Paul Proost;Anja Wuyts;Jozef Van Damme

  • HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

    Peter Cherepanov;Goedele Maertens;Paul Proost;Bart Devreese

  • Gelatinase B functions as regulator and effector in leukocyte biology

    Opdenakker G;Van den Steen Pe;Dubois B;Nelissen I

  • Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.

    J Van Damme;P Proost;J P Lenaerts;G Opdenakker

  • A Potent Antimicrobial Protein from Onion Seeds Showing Sequence Homology to Plant Lipid Transfer Proteins

    B. P. A. Cammue;K. Thevissen;M. Hendriks;K. Eggermont

  • Chemokine-Induced Macrophage Polarization in Inflammatory Conditions.

    Pieter Ruytinx;Paul Proost;Jo Van Damme;Sofie Struyf

  • Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes.

    D. D. Taub;P. Proost;William J Murphy;M. Anver

  • Antimicrobial Peptides From Amaranthus Caudatus Seeds With Sequence Homology to the Cysteine/Glycine-Rich Domain of Chitin-Binding Proteins

    Broekaert Wf;Mariën W;Terras Fr;De Bolle Mf

  • Isolation and characterization of a novel class of plant antimicrobial peptides form Mirabilis jalapa L. seeds.

    B P Cammue;M F De Bolle;F R Terras;P Proost

  • Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.

    Philippe E. Van den Steen;Anja Wuyts;Steven J. Husson;Paul Proost

  • Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

    Paul Proost;Ingrid De Meester;Dominique Schols;Sofie Struyf

  • Purification and identification of 91-kDa neutrophil gelatinase : release by the activating peptide interleukin-8

    Stefan Masure;Paul Proost;Jo Van Damme;Ghislain Opdenakker

  • The unique structural and functional features of CXCL12.

    Rik Janssens;Sofie Struyf;Paul Proost

  • Neutrophil chemoattractant receptors in health and disease: double-edged swords

    Mieke Metzemaekers;Mieke Gouwy;Paul Proost

  • Kinetic Investigation of Chemokine Truncation by CD26/Dipeptidyl Peptidase IV Reveals a Striking Selectivity within the Chemokine Family

    Anne-Marie Lambeir;Paul Proost;Christine Durinx;Gunther Bal

  • Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1

    P Proost;A Wuyts;J Van Damme

  • Synergy in cytokine and chemokine networks amplifies the inflammatory response

    Mieke Gouwy;Sofie Struyf;Paul Proost;Jozef Van Damme

  • Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

    Paul Proost;Evemie Schutyser;Patricia Menten;Sofie Struyf

  • cDNA cloning and molecular analysis of two self-incompatibility alleles from apple

    Wim Broothaerts;Greet A. Janssens;Paul Proost;Willem F. Broekaert

  • Identification of Biologically Active Chemokine Isoforms from Ascitic Fluid and Elevated Levels of CCL18/Pulmonary and Activation-regulated Chemokine in Ovarian Carcinoma

    Evemie Schutyser;Sofie Struyf;Paul Proost;Ghislain Opdenakker

Frequent Co-Authors

Sofie Struyf
Sofie Struyf KU Leuven
Jo Van Damme
Jo Van Damme Rega Institute for Medical Research
Ghislain Opdenakker
Ghislain Opdenakker Rega Institute for Medical Research
Jozef Van Damme
Jozef Van Damme Rega Institute for Medical Research
Mauro M. Teixeira
Mauro M. Teixeira Universidade Federal de Minas Gerais
Willy J. Peumans
Willy J. Peumans Ghent University
Simon Scharpé
Simon Scharpé University of Antwerp
Ingrid De Meester
Ingrid De Meester University of Antwerp

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