World's Best Scientists 2026 revealed!
Award Badge
Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
119
Citations
49840
World Ranking
675
National Ranking
12

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Ghislain Opdenakker is affiliated with the Rega Institute for Medical Research in Belgium. Their research spans several fields, with a primary focus on medicine and biochemistry, genetics, and molecular biology. The scientist's work covers various subfields, including ophthalmology, immunology, molecular biology, cancer research, and infectious diseases.

Opdenakker's research contributions are centered on multiple main topics such as:

  • Protease and inhibitor mechanisms
  • Retinal diseases and treatments
  • Ocular diseases and Behçet's syndrome
  • SARS-CoV-2 and COVID-19 research
  • COVID-19 clinical research studies
  • Neutrophil, myeloperoxidase, and oxidative mechanisms
  • Chemokine receptors and signaling

Their recent publications include the following papers:

  • "STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters," 2020, Nature Communications
  • "A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate," 2020, Nature
  • "Matrix metalloproteinases in arthritis: towards precision medicine," 2023, Nature Reviews Rheumatology
  • "Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)," 2020, International Journal of Molecular Sciences
  • "Protease propeptide structures, mechanisms of activation, and functions," 2020, Critical Reviews in Biochemistry and Molecular Biology

Frequent co-authors collaborating with Opdenakker include:

  • Sofie Struyf
  • Jo Van Damme
  • Jennifer Vandooren
  • Erik Martens
  • Ahmed M. Abu El-Asrar

The scientist has published extensively in a variety of journals, with the most frequent publication venues being:

  • Frontiers in Immunology
  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical & Translational Immunology
  • Ocular Immunology and Inflammation

Best Publications

  • Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

    Katrin Kierdorf;Daniel Erny;Tobias Goldmann;Victor Sander

  • Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)

    Philippe E Van den Steen;Bénédicte Dubois;Inge Nelissen;Pauline M Rudd

  • Concepts and Principles of O-Linked Glycosylation

    Philippe Van den Steen;Pauline M. Rudd;Raymond A. Dwek;Ghislain Opdenakker

  • Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact

    Philippe Van den Steen;Paul Proost;Anja Wuyts;Jozef Van Damme

  • Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases

    Jialiang Hu;Philippe E. Van den Steen;Qing-Xiang A. Sang;Ghislain Opdenakker

  • Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

    Jennifer Vandooren;Philippe E. Van den Steen;Ghislain Opdenakker

  • Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

    J Van Damme;G Opdenakker;R J Simpson;M R Rubira

  • Gelatinase B functions as regulator and effector in leukocyte biology

    Opdenakker G;Van den Steen Pe;Dubois B;Nelissen I

  • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis

    Smriti Agrawal;Per Anderson;Madeleine Durbeej;Nico van Rooijen

  • Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

    Elzbieta Kolaczkowska;Craig N. Jenne;Bas G. J. Surewaard;Ajitha Thanabalasuriar

  • Gelatinase B: a tuner and amplifier of immune functions

    Ghislain Opdenakker;Philippe Van den Steen;Jozef Van Damme

  • Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.

    J Van Damme;P Proost;J P Lenaerts;G Opdenakker

  • Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2

    Kunio Hieshima;Toshio Imai;Ghislain Opdenakker;Jo Van Damme

  • The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.

    Bénédicte Cauwe;Philippe E Van den Steen;Ghislain Opdenakker

  • The MCP/eotaxin subfamily of CC chemokines.

    Els Van Coillie;Jozef Van Damme;Ghislain Opdenakker

  • Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders.

    Koenraad Gijbels;Stefan Masure;Herwig Carton;Ghislain Opdenakker

  • Glycoforms modify the dynamic stability and functional activity of an enzyme.

    Pauline M. Rudd;Heidi C. Joao;Eva Coghill;Pierre Fiten

  • Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.

    Philippe E. Van den Steen;Anja Wuyts;Steven J. Husson;Paul Proost

  • Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

    Paul Proost;Ingrid De Meester;Dominique Schols;Sofie Struyf

  • PLASMINOGEN ACTIVATORS AND MATRIX METALLOPROTEASES, MEDIATORS OF EXTRACELLULAR PROTEOLYSIS IN INFLAMMATORY DEMYELINATION OF THE CENTRAL NERVOUS SYSTEM

    M L Cuzner;Ghislain Opdenakker

Frequent Co-Authors

Paul Proost
Paul Proost KU Leuven
Philippe E. Van den Steen
Philippe E. Van den Steen Rega Institute for Medical Research
Jo Van Damme
Jo Van Damme Rega Institute for Medical Research
Sofie Struyf
Sofie Struyf KU Leuven
Jozef Van Damme
Jozef Van Damme Rega Institute for Medical Research
Alfons Billiau
Alfons Billiau Rega Institute for Medical Research
Robert Snoeck
Robert Snoeck KU Leuven
Karel Geboes
Karel Geboes Ghent University Hospital

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry can open doors to a range of healthcare careers. Increasingly, students are opting for online study due to flexibility and accessibility. Options like ultrasound tech school online make it possible to enter the medical imaging field without attending campus full-time.

Cost is a major concern for many students. If you are looking to minimize expenses, consider the cheapest radiology tech programs, which offer valuable qualifications at a lower price point. For those interested in nutrition and wellness, some of the best dietetics programs provide top-tier graduate education online.

Dreaming of a fast-track entry into healthcare? You might explore accredited medical assistant programs online Michigan, many of which offer robust financial aid.

Whether you aspire to clinical work, diagnostics, or nutrition, online degrees can align with both your career goals and your schedule.

Best Scientists Citing Ghislain Opdenakker

Trending Scientists