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Philippe E. Van den Steen

Philippe E. Van den Steen

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
13678
World Ranking
17857
National Ranking
296

Overview

Philippe E. Van den Steen is affiliated with the Rega Institute for Medical Research in Belgium and has a research focus primarily within the fields of Medicine and Immunology and Microbiology. Their work covers various subfields including Immunology, Public Health, Environmental and Occupational Health, Surgery, Genetics, and Oncology.

The scientist's main research topics include:

  • Malaria Research and Control
  • Immune Cell Function and Interaction
  • Complement system in diseases
  • Mosquito-borne diseases and control
  • Immune Response and Inflammation
  • Transplantation: Methods and Outcomes
  • Hemoglobinopathies and Related Disorders

Van den Steen has published recent papers in several notable venues. These include:

  • "Etiology of lactic acidosis in malaria" (2021), PLoS Pathogens
  • "Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation" (2022), Mucosal Immunology
  • "Hemozoin in Malarial Complications: More Questions Than Answers" (2020), Trends in Parasitology
  • "CCR2 Is Dispensable for Disease Resolution but Required for the Restoration of Leukocyte Homeostasis Upon Experimental Malaria-Associated Acute Respiratory Distress Syndrome" (2021), Frontiers in Immunology
  • "Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome" (2021), PLoS Pathogens

The scientist frequently publishes in the following venues:

  • Frontiers in Immunology
  • PLoS Pathogens
  • The Journal of Heart and Lung Transplantation
  • Trends in Parasitology
  • Parasite Immunology

Collaborations have been established with several co-authors, including:

  • Emilie Pollenus
  • Fran Prenen
  • Sofie Knoops
  • Hendrik Possemiers
  • Leen Vandermosten

The research contributions of Philippe E. Van den Steen emphasize infectious diseases, particularly malaria and its associated complications, along with immune system mechanisms underlying these conditions. The work intersects various disciplines, integrating immunological perspectives with public health and clinical research methodologies. This multidisciplinary approach supports investigations into immune response modulation, inflammatory processes, and disease resolution in both experimental and translational contexts.

Best Publications

  • Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)

    Philippe E Van den Steen;Bénédicte Dubois;Inge Nelissen;Pauline M Rudd

  • Concepts and Principles of O-Linked Glycosylation

    Philippe Van den Steen;Pauline M. Rudd;Raymond A. Dwek;Ghislain Opdenakker

  • Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact

    Philippe Van den Steen;Paul Proost;Anja Wuyts;Jozef Van Damme

  • Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases

    Jialiang Hu;Philippe E. Van den Steen;Qing-Xiang A. Sang;Ghislain Opdenakker

  • Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

    Jennifer Vandooren;Philippe E. Van den Steen;Ghislain Opdenakker

  • Gelatinase B functions as regulator and effector in leukocyte biology

    Opdenakker G;Van den Steen Pe;Dubois B;Nelissen I

  • Gelatinase B: a tuner and amplifier of immune functions

    Ghislain Opdenakker;Philippe Van den Steen;Jozef Van Damme

  • The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.

    Bénédicte Cauwe;Philippe E Van den Steen;Ghislain Opdenakker

  • Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.

    Philippe E. Van den Steen;Anja Wuyts;Steven J. Husson;Paul Proost

  • CXCR3 ligands in disease and therapy.

    Katrien Van Raemdonck;Philippe Van den Steen;Sandra Liekens;Jozef Van Damme

  • Zymography methods for visualizing hydrolytic enzymes

    Jennifer Vandooren;Nathalie Geurts;Erik Martens;Philippe E Van den Steen

  • Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis

    Philippe Van den Steen;Paul Proost;Bernard Grillet;David D Brand

  • The Hemopexin and O-Glycosylated Domains Tune Gelatinase B/MMP-9 Bioavailability via Inhibition and Binding to Cargo Receptors

    Philippe E. Van den Steen;Ilse Van Aelst;Vibeke Hvidberg;Helene Piccard

  • Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins

    Helene Piccard;Philippe E. Van den Steen;Ghislain Opdenakker

  • Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activation in Vivo and Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway

    Veronica C. Ardi;Philippe E. Van den Steen;Ghislain Opdenakker;Bernhard Schweighofer

  • Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain.

    Javier Redondo-Muñoz;Estefanía Ugarte-Berzal;María José Terol;Philippe E. Van den Steen

  • α4β1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells

    Javier Redondo-Muñoz;Estefanía Ugarte-Berzal;José A. García-Marco;Mercedes Hernández del Cerro

  • Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome.

    Philippe Van den Steen;Nathalie Geurts;Katrien Deroost;Ilse Van Aelst

  • Enzymatic degradation of adhesive–dentin interfaces produced by mild self-etch adhesives

    Jan De Munck;Atsushi Mine;Philippe E. Van den Steen;Kirsten L. Van Landuyt

  • Inhibition of Enzymatic Degradation of Adhesive-Dentin Interfaces

    Jan De Munck;Philippe Van den Steen;A Mine;Kirsten Van Landuyt

Frequent Co-Authors

Ghislain Opdenakker
Ghislain Opdenakker Rega Institute for Medical Research
Paul Proost
Paul Proost KU Leuven
Pauline M. Rudd
Pauline M. Rudd University College Cork
Jo Van Damme
Jo Van Damme Rega Institute for Medical Research
Jozef Van Damme
Jozef Van Damme Rega Institute for Medical Research
Raymond A. Dwek
Raymond A. Dwek University of Oxford
Chris J. Janse
Chris J. Janse Leiden University Medical Center
Karolien De Bosscher
Karolien De Bosscher Ghent University
Mark R. Wormald
Mark R. Wormald University of Oxford
Donatella Taramelli
Donatella Taramelli University of Milan

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