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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
13008
World Ranking
11946
National Ranking
113

Overview

Irit Sagi is affiliated with the Weizmann Institute of Science in Israel. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, contributing a substantial number of publications in these domains. Their work extends into several subfields, including Molecular Biology, Immunology, Oncology, Cancer Research, and Physiology.

The scientist's research focuses on topics related to protease and inhibitor mechanisms, peptidase inhibition and analysis, as well as extracellular vesicles in disease. Additional areas of study include monoclonal and polyclonal antibodies research, immune cells in cancer, marine invertebrate physiology, ecology, and CAR-T cell therapy research.

They have authored multiple research articles, including the following notable recent papers:

  • Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers (2020, Cell)
  • The ECM path of senescence in aging: components and modifiers (2020, FEBS Journal)
  • Tumor-reactive antibodies evolve from non-binding and autoreactive precursors (2022, Cell)
  • Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis (2021, The Journal of Experimental Medicine)
  • Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts (2020, Nature Communications)

The scientist frequently collaborates with other researchers, including:

  • Inna Solomonov (23 collaborations)
  • Elee Shimshoni (6 collaborations)
  • Órit Kollet (5 collaborations)
  • Idan Adir (5 collaborations)
  • Vinagolu K. Rajasekhar (4 collaborations)

Their publications appear regularly in several venues, with recurrent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • FEBS Journal
  • PLoS ONE
  • Oncogene

Best Publications

  • Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

    Ayuko Hoshino;Ayuko Hoshino;Han Sang Kim;Han Sang Kim;Linda Bojmar;Linda Bojmar;Linda Bojmar;Kofi Ennu Gyan

  • The extracellular matrix protein agrin promotes heart regeneration in mice

    Elad Bassat;Yara Eid Mutlak;Alex Genzelinakh;Ilya Y. Shadrin

  • Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1.

    M F Summers;L E Henderson;M R Chance;J W Bess

  • Tumor macrophages are pivotal constructors of tumor collagenous matrix.

    Ran Afik;Ehud Zigmond;Milena Vugman;Mordehay Klepfish

  • Structural Differences Between Biogenic Amorphous Calcium Carbonate Phases Using X-ray Absorption Spectroscopy**

    Yael Levi-Kalisman;Sefi Raz;Steve Weiner;Lia Addadi

  • Role of Magnesium Ion in the Stabilization of Biogenic Amorphous Calcium Carbonate: A Structure−Function Investigation

    Yael Politi;David R. Batchelor;Paul Zaslansky;Bradley F. Chmelka

  • Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.

    Dror Noy;Inna Solomonov;Ory Sinkevich;Talmon Arad

  • Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site

    Moran Grossman;Benjamin Born;Matthias Heyden;Dmitry Tworowski

  • Emerging roles of ECM remodeling processes in cancer.

    Vishnu Mohan;Alakesh Das;Irit Sagi

  • Next Generation Matrix Metalloproteinase Inhibitors – Novel Strategies Bring New Prospects

    Maxim Levin;Yael Udi;Inna Solomonov;Irit Sagi

  • Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

    Netta Sela-Passwell;Gabriel Rosenblum;Tsipi Shoham;Irit Sagi

  • Active site electronic structure and dynamics during metalloenzyme catalysis.

    Oded Kleifeld;Anatoly Frenkel;Jan M.L. Martin;Irit Sagi

  • Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

    Netta Sela-Passwell;Raghavendra Kikkeri;Orly Dym;Haim Rozenberg

  • Matrix metalloproteinases: The sculptors of chronic cutaneous wounds.

    Venkat Raghavan Krishnaswamy;Dvir Mintz;Irit Sagi

  • Inhibition of the Tumor Necrosis Factor-α-converting Enzyme by Its Pro Domain

    Patricia E. Gonzales;Ariel Solomon;Ann B. Miller;M. Anthony Leesnitzer

  • Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix

    Moran Grossman;Nir Ben-Chetrit;Alina Zhuravlev;Ran Afik

  • PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

    Shiri Gur-Cohen;Tomer Itkin;Sagarika Chakrabarty;Claudine Graf

  • From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases

    Matthieu Rouffet;César Augusto F. de Oliveira;Yael Udi;Arpita Agrawal

  • The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair

    Ravid Shechter;Catarina Raposo;Anat London;Irit Sagi

  • The ECM path of senescence in aging: components and modifiers.

    Naama Levi;Nurit Papismadov;Inna Solomonov;Irit Sagi

Frequent Co-Authors

Anatoly I. Frenkel
Anatoly I. Frenkel Stony Brook University
Abraham Shanzer
Abraham Shanzer Weizmann Institute of Science
Mark R. Chance
Mark R. Chance Case Western Reserve University
Wolfram Ruf
Wolfram Ruf Johannes Gutenberg University of Mainz
Yinon Rudich
Yinon Rudich Weizmann Institute of Science
Martina Havenith
Martina Havenith Ruhr University Bochum
Claudio Luchinat
Claudio Luchinat University of Florence
Lia Addadi
Lia Addadi Weizmann Institute of Science
Tamar Geiger
Tamar Geiger Tel Aviv University
Orit Kollet
Orit Kollet Weizmann Institute of Science

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