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Sofie Struyf

Sofie Struyf

D-Index & Metrics

Immunology

D-Index
80
Citations
21811
World Ranking
1638
National Ranking
21

Overview

Sofie Struyf is affiliated with KU Leuven in Belgium and has a research focus within medicine and immunology. Their body of work spans multiple fields, including immunology and microbiology, as well as biochemistry, genetics, and molecular biology.

The scientist's research contributions are concentrated in several subfields: immunology, molecular biology, oncology, ophthalmology, and pulmonary and respiratory medicine. These areas form the foundation for their investigations into immune response mechanisms and disease processes.

Key topics addressed in their work include:

  • Neutrophil, myeloperoxidase, and oxidative mechanisms
  • Chemokine receptors and signaling
  • Immune response and inflammation
  • Retinal diseases and treatments
  • Cell adhesion molecules research
  • Amyloidosis: diagnosis, treatment, outcomes
  • Neonatal respiratory health research

Sofie Struyf has published extensively with frequent co-authors including Paul Proost, Mieke Gouwy, Ghislain Opdenakker, Jo Van Damme, and Lotte Vanbrabant. Their scholarly work commonly appears in journals such as the International Journal of Molecular Sciences, Frontiers in Immunology, Clinical & Translational Immunology, Ocular Immunology and Inflammation, and Cancers.

Selected recent papers demonstrating the scope of their research include:

  • "Studying Neutrophil Function in vitro: Cell Models and Environmental Factors," 2021, Journal of Inflammation Research
  • "Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)," 2020, International Journal of Molecular Sciences
  • "Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy," 2021, Frontiers in Immunology
  • "Serum Amyloid A1 (SAA1) Revisited: Restricted Leukocyte-Activating Properties of Homogeneous SAA1," 2020, Frontiers in Immunology
  • "Method Matters: Effect of Purification Technology on Neutrophil Phenotype and Function," 2022, Frontiers in Immunology

Best Publications

  • Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.

    Emmanuel Le Poul;Cecile Loison;Sofie Struyf;Jean-Yves Springael

  • The CC chemokine CCL20 and its receptor CCR6.

    Evemie Schutyser;Sofie Struyf;Jozef Van Damme

  • The role of CXC chemokines and their receptors in cancer

    Jo Vandercappellen;Jozef Van Damme;Sofie Struyf

  • Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

    Dominique Schols;Sofie Struyf;Jo Van Damme;José A. Esté

  • Chemokine-Induced Macrophage Polarization in Inflammatory Conditions.

    Pieter Ruytinx;Paul Proost;Jo Van Damme;Sofie Struyf

  • Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

    Paul Proost;Ingrid De Meester;Dominique Schols;Sofie Struyf

  • The unique structural and functional features of CXCL12.

    Rik Janssens;Sofie Struyf;Paul Proost

  • CXCR3 ligands in disease and therapy.

    Katrien Van Raemdonck;Philippe Van den Steen;Sandra Liekens;Jozef Van Damme

  • Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands.

    Mieke Metzemaekers;Vincent Vanheule;Rik Janssens;Sofie Struyf

  • Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.

    Marisa Vulcano;Cristina Albanesi;Antonella Stoppacciaro;Renzo Bagnati

  • Synergy in cytokine and chemokine networks amplifies the inflammatory response

    Mieke Gouwy;Sofie Struyf;Paul Proost;Jozef Van Damme

  • Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

    Paul Proost;Evemie Schutyser;Patricia Menten;Sofie Struyf

  • Identification of Biologically Active Chemokine Isoforms from Ascitic Fluid and Elevated Levels of CCL18/Pulmonary and Activation-regulated Chemokine in Ovarian Carcinoma

    Evemie Schutyser;Sofie Struyf;Paul Proost;Ghislain Opdenakker

  • Processing by CD26/dipeptidyl-peptidase IV reduces the chemotactic and anti-HIV-1 activity of stromal-cell-derived factor-1α

    Paul Proost;Sofie Struyf;Dominique Schols;Christine Durinx

  • Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults.

    Mieke De Buck;Mieke Gouwy;Ji Ming Wang;Jacques Van Snick

  • Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.

    Paul Proost;Tamara Loos;Anneleen Mortier;Evemie Schutyser

  • Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet Factor-4/CXCL4 and Potent Inhibitor of Angiogenesis

    Sofie Struyf;Marie D Burdick;Paul Proost;Jozef Van Damme

  • Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV.

    van E Coillie;P. Proost;van I Aelst;S. Struyf

  • Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist.

    Paul Proost;Patricia Menten;Sofie Struyf;Evemie Schutyser

  • Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor.

    Sofie Struyf;Ingrid De Meester;Simon Scharpé;Jean-Pierre Lenaerts

  • GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors

    Klara Gijsbers;Mieke Gouwy;Sofie Struyf;Anja Wuyts

  • Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy

    Ahmed M Abu El-Asrar;Sofie Struyf;Dustan Kangave;Karel Geboes

  • CD26/Dipeptidyl-Peptidase IV Down-Regulates the Eosinophil Chemotactic Potency, But Not the Anti-HIV Activity of Human Eotaxin by Affecting Its Interaction with CC Chemokine Receptor 3

    Struyf S;Proost P;Schols D;De Clercq E

Frequent Co-Authors

Paul Proost
Paul Proost KU Leuven
Jo Van Damme
Jo Van Damme Rega Institute for Medical Research
Ghislain Opdenakker
Ghislain Opdenakker Rega Institute for Medical Research
Jozef Van Damme
Jozef Van Damme Rega Institute for Medical Research
Karel Geboes
Karel Geboes Ghent University Hospital
Silvano Sozzani
Silvano Sozzani Sapienza University of Rome
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Marc Parmentier
Marc Parmentier Université Libre de Bruxelles
Simon Scharpé
Simon Scharpé University of Antwerp

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