World's Best Scientists 2026 revealed!
Chikao Morimoto

Chikao Morimoto

D-Index & Metrics

Immunology

D-Index
95
Citations
29318
World Ranking
908
National Ranking
30

Medicine

D-Index
96
Citations
29436
World Ranking
9787
National Ranking
271

Overview

Chikao Morimoto is affiliated with Juntendo University in Japan and has a research profile focused largely on medicine, biochemistry, genetics, molecular biology, and immunology and microbiology. Their work spans multiple subfields, including oncology, immunology, molecular biology, cancer research, and pulmonary and respiratory medicine.

The scientist's research has concentrated on topics such as peptidase inhibition and analysis, T-cell and B-cell immunology, immune cell function and interaction, protease and inhibitor mechanisms, neuropeptides and animal physiology, cancer with associated hypoxia and metabolism pathways, as well as IL-33, ST2, and ILC pathways.

Notable papers authored or co-authored by Chikao Morimoto include:

  • Single-cell atlas of colonic CD8+ T cells in ulcerative colitis, 2020, published in Nature Medicine
  • Anti-Human CD9 Fab Fragment Antibody Blocks the Extracellular Vesicle-Mediated Increase in Malignancy of Colon Cancer Cells, 2022, Cells
  • CD26/Dipeptidyl Peptidase IV and Its Multiple Biological Functions, 2021, Cureus
  • IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells, 2021, Cell Death and Disease
  • Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV, 2021, Journal of Allergy and Clinical Immunology

Chikao Morimoto frequently publishes in journals such as:

  • Cells
  • International Journal of Molecular Sciences
  • Respirology
  • Nature Medicine
  • Cell Death and Disease

Common co-authors collaborating with Morimoto include:

  • Ryo Hatano
  • Kei Ohnuma
  • Taketo Yamada
  • Nam H. Dang
  • Takeshi Kawasaki

The breadth of Chikao Morimoto's work incorporates experimental and clinical research, largely examining immune mechanisms in cancer and inflammatory diseases. Their publications highlight an engagement with immune cell biology, signaling pathways associated with disease resistance, and molecular mechanisms involved in cancer malignancy and progression.

Best Publications

  • The isolation and characterization of the human suppressor inducer T cell subset.

    C Morimoto;N L Letvin;J A Distaso;W R Aldrich

  • The isolation and characterization of the human helper inducer T cell subset.

    C Morimoto;N L Letvin;A W Boyd;M Hagan

  • Direct association of adenosine deaminase with a T cell activation antigen, CD26

    Junichi Kameoka;Toshiaki Tanaka;Yoshihisa Nojima;Stuart F. Schlossman

  • B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

    Claude D. Gimmi;Gordon J. Freeman;John G. Gribben;Kanji Sugita

  • Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects.

    Noriko Otsuki;Nam H. Dang;Emi Kumagai;Akira Kondo

  • Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

    Noriaki Shimizu;Noritada Yoshikawa;Naoki Ito;Takako Maruyama

  • The structure and function of CD26 in the T‐cell immune response

    Chikao Morimoto;Stuart F. Schlossman

  • Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110.

    AS Freedman;JM Munro;GE Rice;MP Bevilacqua

  • Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

    Yoshihisa Nojima;Noritsugu Morino;Toshihide Mimura;Ken Hamasaki

  • B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production

    Kazunaga Agematsu;Haruo Nagumo;Fen Chun Yang;Takayuki Nakazawa

  • Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.

    Takami Matsuyama;Akira Yamada;Jonathan Kay;Kenneth M. Yamada

  • CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-κB and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-κB-inducing Kinase *

    Hisaya Akiba;Hiroyasu Nakano;Shigeyuki Nishinaka;Masahisa Shindo

  • Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

    K Tachibana;T Sato;N D'Avirro;C Morimoto

  • Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody.

    Chikao Morimoto;David A. Hafler;Howard L. Weiner;Norman L. Letvin

  • Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice

    Jun-ichi Shirakawa;Hideki Fujii;Kei Ohnuma;Koichiro Sato

  • Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations.

    E L Reinherz;C Morimoto;K A Fitzgerald;R E Hussey

  • A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes.

    H Tsubota;C I Lord;D I Watkins;C Morimoto

  • Generation of Plasma Cells From Peripheral Blood Memory B Cells: Synergistic Effect of Interleukin-10 and CD27/CD70 Interaction

    Kazunaga Agematsu;Haruo Nagumo;Haruo Nagumo;Haruo Nagumo;Yumiko Oguchi;Yumiko Oguchi;Yumiko Oguchi;Takayuki Nakazawa;Takayuki Nakazawa;Takayuki Nakazawa

  • Response patterns of purified myeloma cells to hematopoietic growth factors.

    Kenneth C. Anderson;Rebecca M. Jones;Chikao Morimoto;Pearl Leavitt

  • Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function

    Kei Ohnuma;Nam H. Dang;Chikao Morimoto

  • Cloning and functional expression of the T cell activation antigen CD26.

    T Tanaka;D Camerini;B Seed;Y Torimoto

Frequent Co-Authors

Stuart F. Schlossman
Stuart F. Schlossman Harvard University
Hirotoshi Tanaka
Hirotoshi Tanaka Keio University
Tsutomu Takeuchi
Tsutomu Takeuchi Keio University
Norman L. Letvin
Norman L. Letvin Beth Israel Deaconess Medical Center
Michiie Sakamoto
Michiie Sakamoto Keio University
Ellis L. Reinherz
Ellis L. Reinherz Harvard University
Tetsuji Kobata
Tetsuji Kobata Tokyo Medical and Dental University
Christopher E. Rudd
Christopher E. Rudd University of Montreal
Jerome Ritz
Jerome Ritz Harvard University
David A. Hafler
David A. Hafler Yale University

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