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Biology and Biochemistry

D-Index
55
Citations
10710
World Ranking
15075
National Ranking
415

Overview

Mark D. Gorrell is affiliated with the University of Sydney in Australia and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans multiple subfields, with notable activity in oncology, surgery, molecular biology, epidemiology, and hepatology.

Their research encompasses several specialized topics, including peptidase inhibition and analysis, protease and inhibitor mechanisms, neuropeptides and animal physiology, pancreatitis pathology and treatment, liver disease diagnosis and treatment, liver disease and transplantation, as well as genetics and neurodevelopmental disorders.

Recent publications by Mark D. Gorrell include:

  • Animal and translational models of SARS-CoV-2 infection and COVID-19, 2020, Mucosal Immunology
  • COVID-19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity?, 2020, Journal of Diabetes
  • DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling, 2022, Science Immunology
  • Deletion of fibroblast activation protein provides atheroprotection, 2020, Cardiovascular Research
  • A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2, 2020, Molecules

Frequent coauthors who have collaborated extensively with Gorrell include Geoffrey W. McCaughan, Hui Zhang, Michelle Sui Wen Xiang, Jiali Huang, and Badwi B. Boumelhem.

The venues in which Gorrell has published most frequently feature journals and platforms such as Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Preprints.org, bioRxiv (Cold Spring Harbor Laboratory), Cancers, and Journal of Diabetes.

Best Publications

  • 3-dimensional imaging of collagen using second harmonic generation.

    Guy Cox;Eleanor Kable;Allan Jones;Ian Fraser

  • Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage

    Tamas Oravecz;Marina Pall;Gregory Roderiquez;Mark D. Gorrell

  • CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes.

    M. D. Gorrell;V. Gysbers;G. W. McCaughan

  • Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders.

    Mark D. Gorrell

  • Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy

    Elizabeth J. Hamson;Fiona M. Keane;Stefan Tholen;Oliver Schilling

  • Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis

    Miriam T. Levy;Geoffrey W. McCaughan;Catherine A. Abbott;John E. Park

  • Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8.

    Catherine A. Abbott;Denise M. T. Yu;Erica Woollatt;Grant R. Sutherland

  • Diabetes and nonalcoholic Fatty liver disease: a pathogenic duo.

    K. H. Williams;K. H. Williams;N. A. Shackel;N. A. Shackel;M. D. Gorrell;M. D. Gorrell;S. V. McLennan;S. V. McLennan

  • Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition

    Mark Kirby;Denise M. T. Yu;Stephen P. O'connor;Mark D. Gorrell

  • Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line.

    Xin Maggie Wang;Denise Ming Tse Yu;Geoffrey W. McCaughan;Mark D. Gorrell

  • The dipeptidyl peptidase IV family in cancer and cell biology

    Denise M. T. Yu;Tsun-Wen Yao;Sumaiya Chowdhury;Naveed A. Nadvi

  • Insights into the Pathobiology of Hepatitis C Virus-Associated Cirrhosis : Analysis of Intrahepatic Differential Gene Expression

    Nicholas A. Shackel;Peter H. McGuinness;Catherine A. Abbott;Mark D. Gorrell;Mark D. Gorrell

  • Animal and translational models of SARS-CoV-2 infection and COVID-19.

    M. D. Johansen;A. Irving;X. Montagutelli;M. D. Tate;M. D. Tate

  • Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression

    N A Shackel;P H McGuinness;C A Abbott;M D Gorrell

  • Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes.

    M D Gorrell;M R Brandon;D Sheffer;R J Adams

  • Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity.

    Katerina Ajami;Catherine A Abbott;Geoffrey W McCaughan;Mark D Gorrell

  • COVID-19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity?

    Margaret F Bassendine;Simon H Bridge;Simon H Bridge;Geoffrey W McCaughan;Mark D Gorrell

  • Two highly conserved glutamic acid residues in the predicted β propeller domain of dipeptidyl peptidase IV are required for its enzyme activity

    Catherine A Abbott;Geoffrey W McCaughan;Mark D Gorrell

  • Neuropeptide Y, B‐type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein‐α

    Fiona M. Keane;Naveed A. Nadvi;Tsun-Wen Yao;Mark D. Gorrell

  • Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domain

    Catherine A. Abbott;Geoffrey W. McCaughan;Miriam T. Levy;W. Bret Church

Frequent Co-Authors

Geoffrey W. McCaughan
Geoffrey W. McCaughan University of Sydney
Wolfgang Weninger
Wolfgang Weninger Medical University of Vienna
William W. Bachovchin
William W. Bachovchin Tufts University
Jeremy S. Webb
Jeremy S. Webb University of Southampton
Joel P. Mackay
Joel P. Mackay University of Sydney
Robert Huber
Robert Huber University of Duisburg-Essen
Magdalena Plebanski
Magdalena Plebanski RMIT University
Opendra Narayan
Opendra Narayan University of Kansas
Oliver Schilling
Oliver Schilling University of Freiburg
Patrick Bertolino
Patrick Bertolino Centenary Institute of Cancer Medicine and Cell Biology

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