World's Best Scientists 2026 revealed!
William W. Bachovchin

William W. Bachovchin

D-Index & Metrics

Chemistry

D-Index
44
Citations
6868
World Ranking
16884
National Ranking
4173

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors

Overview

William W. Bachovchin is affiliated with Tufts University in the United States and has contributed extensively to the field of medicine, focusing on oncology, surgery, molecular biology, radiology, nuclear medicine, and cancer research.

The scientist's research covers a range of topics including:

  • Peptidase Inhibition and Analysis
  • Monoclonal and Polyclonal Antibodies Research
  • Radiopharmaceutical Chemistry and Applications
  • Esophageal Cancer Research and Treatment
  • Gastrointestinal Tumor Research and Treatment
  • Liver Disease Diagnosis and Treatment
  • Cardiac Structural Anomalies and Repair

Bachovchin has published in several scientific venues, with the most frequent publications appearing in:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Nuclear Medicine
  • Cancers
  • Protein Expression and Purification

Frequent collaborators include Jack H. Lai, Amber Su, Jaffer A. Ajani, Frank McKeon, and Shuang Pan.

Recent published papers by the scientist include:

  • Preclinical Development of PNT6555, a Boronic Acid-Based, Fibroblast Activation Protein-α (FAP)-Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors, 2023, Journal of Nuclear Medicine
  • Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma, 2021, Cancers
  • Characterization of a single chain variable fragment of nivolumab that targets PD-1 and blocks PD-L1 binding, 2020, Protein Expression and Purification
  • Abstract 1815: AVA6000, a novel Precision medicine, targeted to the tumor microenvironment via Fibroblast Activation Protein (FAP) mediated cleavage, 2022, Cancer Research
  • Activation Mechanism and Structural Assembly of the Mycobacterium tuberculosis ClpP1P2 Protease and Its Associated ATPases, 2025, bioRxiv (Cold Spring Harbor Laboratory)

William W. Bachovchin was recognized as a Fellow of the National Academy of Inventors in 2020.

Best Publications

  • Nitrogen-15 nuclear magnetic resonance spectroscopy. The state of histidine in the catalytic triad of .alpha.-lytic protease. Implications for the charge-relay mechanism of peptide-bond cleavage by serine proteases

    William W. Bachovchin;John D. Roberts

  • DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

    Marian C Okondo;Darren C Johnson;Ramya Sridharan;Eun Bin Go

  • 15N NMR spectroscopy of hydrogen-bonding interactions in the active site of serine proteases: evidence for a moving histidine mechanism.

    William W. Bachovchin

  • Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function.

    G R Flentke;E Munoz;B T Huber;A G Plaut

  • Structure−Activity Relationships of Boronic Acid Inhibitors of Dipeptidyl Peptidase IV. 1. Variation of the P2 Position of Xaa-boroPro Dipeptides

    Simon J. Coutts;Terence A. Kelly;Roger J. Snow;Charles A. Kennedy

  • A Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Proteases? Theory Versus Experiment

    Elissa L. Ash;James L. Sudmeier;James L. Sudmeier;Edward C. De Fabo;Edward C. De Fabo;William W. Bachovchin;William W. Bachovchin

  • Nitrogen-15 NMR spectroscopy of the catalytic-triad histidine of a serine protease in peptide boronic acid inhibitor complexes

    William W. Bachovchin;Winona Y. L. Wong;Shauna Farr-Jones;Ashok B. Shenvi

  • Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.

    W W Bachovchin;A G Plaut;G R Flentke;M Lynch

  • Unusual 1H NMR chemical shifts support (His) Cɛ1—H⋅⋅⋅O⩵C H-bond: Proposal for reaction-driven ring flip mechanism in serine protease catalysis

    Elissa L. Ash;James L. Sudmeier;Regina M. Day;Matthew Vincent

  • Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness.

    M Subramanyam;W G Gutheil;W W Bachovchin;B T Huber

  • High-frequency dynamic nuclear polarization in MAS spectra of membrane and soluble proteins.

    Melanie Rosay;Jonathan C. Lansing;Kristin C. Haddad;William W. Bachovchin

  • Solution structure of the origin DNA-binding domain of SV40 T-antigen.

    Xuelian Luo;David G. Sanford;Peter A. Bullock;William W. Bachovchin

  • Mechanism of action of adenosylcobalamin: glycerol and other substrate analogs as substrates and inactivators for propanediol dehydratase - kinetics, stereospecificity, and mechanism

    William W. Bachovchin;Robert G. Eagar;Kevin W. Moore;John H. Richards

  • Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase.

    Sarah E. Poplawski;Jack H. Lai;Youhua Li;Zhiping Jin

  • Studies on Proline Boronic Acid Dipeptide Inhibitors of Dipeptidyl Peptidase IV: Identification of a Cyclic Species Containing a B-N Bond

    Roger J. Snow;William W. Bachovchin;Randall W. Barton;Scot J. Campbell

  • Acid-base and tautomeric equilibriums in the solid state: nitrogen-15 NMR spectroscopy of histidine and imidazole

    M. Munowitz;W. W. Bachovchin;J. Herzfeld;C. M. Dobson

  • Review: Contributions of NMR spectroscopy to the study of hydrogen bonds in serine protease active sites

    William W. Bachovchin

  • Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids.

    Charles A. Kettner;Roger Bone;David A. Agard;William W. Bachovchin

  • Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice

    Ming-Hui Fan;Qiang Zhu;Hui-Hua Li;Hyun-Jeong Ra

  • Chemical and Biological Evaluation of Dipeptidyl Boronic Acid Proteasome Inhibitors for Use in Prodrugs and Pro-Soft Drugs Targeting Solid Tumors

    Lawrence J. Milo;Jack H. Lai;Wengen Wu;Yuxin Liu

  • Crystal versus solution structures of enzymes: NMR spectroscopy of a crystalline serine protease.

    Steven O. Smith;Shauna Farr-Jones;Robert G. Griffin;William W. Bachovchin

Frequent Co-Authors

Andrew G. Plaut
Andrew G. Plaut Tufts Medical Center
Mark D. Gorrell
Mark D. Gorrell University of Sydney
Geoffrey W. McCaughan
Geoffrey W. McCaughan University of Sydney
Daniel J. Drucker
Daniel J. Drucker Lunenfeld-Tanenbaum Research Institute
John H. Richards
John H. Richards California Institute of Technology
Brigitte T. Huber
Brigitte T. Huber Tufts University
Klaus Albert
Klaus Albert University of Tübingen
John D. Roberts
John D. Roberts Yale University
Eduardo Muñoz
Eduardo Muñoz University of Córdoba

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