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William W. Bachovchin

William W. Bachovchin

Tufts University
United States

D-Index & Metrics

Chemistry

D-Index
44
Citations
6868
World Ranking
16882
National Ranking
4172

William W. Bachovchin publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where William W. Bachovchin sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 131 publications — 8th percentile

8% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

William W. Bachovchin D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where William W. Bachovchin sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 44 D-Index — 7th percentile

7% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors

Overview

William W. Bachovchin is affiliated with Tufts University in the United States and has contributed extensively to the field of medicine, focusing on oncology, surgery, molecular biology, radiology, nuclear medicine, and cancer research.

The scientist's research covers a range of topics including:

  • Peptidase Inhibition and Analysis
  • Monoclonal and Polyclonal Antibodies Research
  • Radiopharmaceutical Chemistry and Applications
  • Esophageal Cancer Research and Treatment
  • Gastrointestinal Tumor Research and Treatment
  • Liver Disease Diagnosis and Treatment
  • Cardiac Structural Anomalies and Repair

Bachovchin has published in several scientific venues, with the most frequent publications appearing in:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Nuclear Medicine
  • Cancers
  • Protein Expression and Purification

Frequent collaborators include Jack H. Lai, Amber Su, Jaffer A. Ajani, Frank McKeon, and Shuang Pan.

Recent published papers by the scientist include:

  • Preclinical Development of PNT6555, a Boronic Acid-Based, Fibroblast Activation Protein-α (FAP)-Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors, 2023, Journal of Nuclear Medicine
  • Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma, 2021, Cancers
  • Characterization of a single chain variable fragment of nivolumab that targets PD-1 and blocks PD-L1 binding, 2020, Protein Expression and Purification
  • Abstract 1815: AVA6000, a novel Precision medicine, targeted to the tumor microenvironment via Fibroblast Activation Protein (FAP) mediated cleavage, 2022, Cancer Research
  • Activation Mechanism and Structural Assembly of the Mycobacterium tuberculosis ClpP1P2 Protease and Its Associated ATPases, 2025, bioRxiv (Cold Spring Harbor Laboratory)

William W. Bachovchin was recognized as a Fellow of the National Academy of Inventors in 2020.

Best Publications

  • Nitrogen-15 nuclear magnetic resonance spectroscopy. The state of histidine in the catalytic triad of .alpha.-lytic protease. Implications for the charge-relay mechanism of peptide-bond cleavage by serine proteases

    William W. Bachovchin;John D. Roberts

  • DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

    Marian C Okondo;Darren C Johnson;Ramya Sridharan;Eun Bin Go

  • 15N NMR spectroscopy of hydrogen-bonding interactions in the active site of serine proteases: evidence for a moving histidine mechanism.

    William W. Bachovchin

  • Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function.

    G R Flentke;E Munoz;B T Huber;A G Plaut

  • Structure−Activity Relationships of Boronic Acid Inhibitors of Dipeptidyl Peptidase IV. 1. Variation of the P2 Position of Xaa-boroPro Dipeptides

    Simon J. Coutts;Terence A. Kelly;Roger J. Snow;Charles A. Kennedy

  • A Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Proteases? Theory Versus Experiment

    Elissa L. Ash;James L. Sudmeier;James L. Sudmeier;Edward C. De Fabo;Edward C. De Fabo;William W. Bachovchin;William W. Bachovchin

  • Nitrogen-15 NMR spectroscopy of the catalytic-triad histidine of a serine protease in peptide boronic acid inhibitor complexes

    William W. Bachovchin;Winona Y. L. Wong;Shauna Farr-Jones;Ashok B. Shenvi

  • Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.

    W W Bachovchin;A G Plaut;G R Flentke;M Lynch

  • Unusual 1H NMR chemical shifts support (His) Cɛ1—H⋅⋅⋅O⩵C H-bond: Proposal for reaction-driven ring flip mechanism in serine protease catalysis

    Elissa L. Ash;James L. Sudmeier;Regina M. Day;Matthew Vincent

  • Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness.

    M Subramanyam;W G Gutheil;W W Bachovchin;B T Huber

  • High-frequency dynamic nuclear polarization in MAS spectra of membrane and soluble proteins.

    Melanie Rosay;Jonathan C. Lansing;Kristin C. Haddad;William W. Bachovchin

  • Solution structure of the origin DNA-binding domain of SV40 T-antigen.

    Xuelian Luo;David G. Sanford;Peter A. Bullock;William W. Bachovchin

  • Mechanism of action of adenosylcobalamin: glycerol and other substrate analogs as substrates and inactivators for propanediol dehydratase - kinetics, stereospecificity, and mechanism

    William W. Bachovchin;Robert G. Eagar;Kevin W. Moore;John H. Richards

  • Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase.

    Sarah E. Poplawski;Jack H. Lai;Youhua Li;Zhiping Jin

  • Studies on Proline Boronic Acid Dipeptide Inhibitors of Dipeptidyl Peptidase IV: Identification of a Cyclic Species Containing a B-N Bond

    Roger J. Snow;William W. Bachovchin;Randall W. Barton;Scot J. Campbell

  • Acid-base and tautomeric equilibriums in the solid state: nitrogen-15 NMR spectroscopy of histidine and imidazole

    M. Munowitz;W. W. Bachovchin;J. Herzfeld;C. M. Dobson

  • Review: Contributions of NMR spectroscopy to the study of hydrogen bonds in serine protease active sites

    William W. Bachovchin

  • Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids.

    Charles A. Kettner;Roger Bone;David A. Agard;William W. Bachovchin

  • Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice

    Ming-Hui Fan;Qiang Zhu;Hui-Hua Li;Hyun-Jeong Ra

  • Chemical and Biological Evaluation of Dipeptidyl Boronic Acid Proteasome Inhibitors for Use in Prodrugs and Pro-Soft Drugs Targeting Solid Tumors

    Lawrence J. Milo;Jack H. Lai;Wengen Wu;Yuxin Liu

  • Crystal versus solution structures of enzymes: NMR spectroscopy of a crystalline serine protease.

    Steven O. Smith;Shauna Farr-Jones;Robert G. Griffin;William W. Bachovchin

Frequent Co-Authors

Andrew G. Plaut
Andrew G. Plaut Tufts Medical Center
Mark D. Gorrell
Mark D. Gorrell University of Sydney
Geoffrey W. McCaughan
Geoffrey W. McCaughan University of Sydney
Daniel J. Drucker
Daniel J. Drucker Lunenfeld-Tanenbaum Research Institute
Robert G. Griffin
Robert G. Griffin MIT
John H. Richards
John H. Richards California Institute of Technology
Brigitte T. Huber
Brigitte T. Huber Tufts University
Klaus Albert
Klaus Albert University of Tübingen
John D. Roberts
John D. Roberts Yale University
Eduardo Muñoz
Eduardo Muñoz University of Córdoba

External Links

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