World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
58
Citations
9312
World Ranking
10866
National Ranking
137

Biology and Biochemistry

D-Index
59
Citations
10138
World Ranking
12773
National Ranking
235

Overview

Koen Augustyns is affiliated with the University of Antwerp in Belgium and focuses their research primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans various subfields, including Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Cancer Research, and Radiology, Nuclear Medicine, and Imaging.

Augustyns' research covers several key topics, with a notable emphasis on Peptidase Inhibition and Analysis, Ferroptosis and cancer prognosis, Neuropeptides and Animal Physiology, Protease and Inhibitor Mechanisms, Click Chemistry and Applications, Radiopharmaceutical Chemistry and Applications, and RNA modifications and cancer.

The scientist has published extensively, with frequent contributions to journals such as the Journal of Medicinal Chemistry, Nature Communications, International Journal of Molecular Sciences, Frontiers in Chemistry, and ACS Omega.

Some of their recent papers include:

  • Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs (2020, Trends in Pharmacological Sciences)
  • Targeting ferroptosis protects against experimental (multi)organ dysfunction and death (2022, Nature Communications)
  • Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors (2023, Trends in Pharmacological Sciences)
  • Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression (2023, Cell Death and Differentiation)
  • Selected strategies to fight pathogenic bacteria (2023, Journal of Enzyme Inhibition and Medicinal Chemistry)

Co-authorship reflects collaboration with several frequent partners, including Pieter Van der Veken, Ingrid De Meester, Tom Vanden Berghe, Maya Berg, and Camilla Scarpellini.

Best Publications

  • Kinetic Investigation of Chemokine Truncation by CD26/Dipeptidyl Peptidase IV Reveals a Striking Selectivity within the Chemokine Family

    Anne-Marie Lambeir;Paul Proost;Christine Durinx;Gunther Bal

  • Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

    Koen Jansen;Leen Heirbaut;Robert Verkerk;Jonathan D Cheng

  • Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold.

    Koen Jansen;Leen Heirbaut;Jonathan D. Cheng;Jurgen Joossens

  • When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157.

    Diego Rojas-Rivera;Tinneke Delvaeye;Ria Roelandt;Wim Nerinckx

  • In vitro antioxidant profile of phenolic acid derivatives.

    Paul Cos;Padinchare Rajan;Irina Vedernikova;Mario Calomme

  • Truncation of Macrophage-derived Chemokine by CD26/ Dipeptidyl-Peptidase IV beyond Its Predicted Cleavage Site Affects Chemotactic Activity and CC Chemokine Receptor 4 Interaction

    Paul Proost;Sofie Struyf;Dominique Schols;Ghislain Opdenakker

  • The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors.

    K Augustyns;G Bal;G Thonus;A Belyaev

  • Regulation of intestinal permeability: The role of proteases.

    Hanne Van Spaendonk;Hannah Ceuleers;Leonie Witters;Eveline Patteet

  • Synthesis and evaluation of caffeic acid amides as antioxidants

    Padinchare Rajan;Irina Vedernikova;Paul Cos;Dirk Vanden Berghe

  • Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

    Sofie Martens;Sam Hofmans;Wim Declercq;Koen Augustyns

  • Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors.

    Unknown

  • Fluoro-Olefins as Peptidomimetic Inhibitors of Dipeptidyl Peptidases

    Pieter Van der Veken;Kristel Senten;István Kertèsz;Ingrid De Meester

  • Serine peptidase modulators

    Simon Scharpe;Ingrid De Meester;Anne-Marie Lambeir;Koen Augustyns

  • Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

    Unknown

  • Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.

    Lars Devisscher;Samya Van Coillie;Sam Hofmans;Dries Van Rompaey

  • Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

    Sam Hofmans;Tom Vanden Berghe;Lars Devisscher;Behrouz Hassannia

  • Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors

    A. Belyaev;Xuemei Zhang;K. Augustyns;A.-M. Lambeir

  • Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells.

    Izabela M. D. Bastos;Philippe Grellier;Natalia F. Martins;Gloria Cadavid-Restrepo

  • ClpP Protease, a Promising Antimicrobial Target

    Carlos Moreno-Cinos;Kenneth Goossens;Irene G. Salado;Pieter Van Der Veken

  • Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

    M. Berg;P. Van der Veken;A. Goeminne;A. Haemers

  • Natural substrates of dipeptidyl peptidase IV.

    I. De Meester;C Durinx;G Bal;Paul Proost

  • Prolyl oligopeptidase stimulates the aggregation of α-synuclein

    Inger Brandt;Melanie Gérard;Kjell Sergeant;Bart Devreese

  • Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis

    Veerle Matheeussen;Yannick Waumans;Wim Martinet;Sebastiaan Van Goethem

  • The Unique Properties of Dipeptidyl-peptidase IV (DPP IV I CD26) and the Therapeutic Potential of DPP IV Inhibitors

    Unknown

Frequent Co-Authors

Anne-Marie Lambeir
Anne-Marie Lambeir University of Antwerp
Ingrid De Meester
Ingrid De Meester University of Antwerp
Simon Scharpé
Simon Scharpé University of Antwerp
Louis Maes
Louis Maes University of Antwerp
Paul Cos
Paul Cos University of Antwerp
Peter Vandenabeele
Peter Vandenabeele Ghent University
Jan Steyaert
Jan Steyaert Vrije Universiteit Brussel
Walter Weder
Walter Weder University of Zurich
Wim Martinet
Wim Martinet University of Antwerp

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