World's Best Scientists 2026 revealed!
Pekka T. Männistö

Pekka T. Männistö

D-Index & Metrics

Chemistry

D-Index
55
Citations
11358
World Ranking
12083
National Ranking
70

Overview

Pekka T. Männistö is affiliated with the University of Helsinki in Finland. Their research primarily focuses on medicine, with particular attention to neurology and cognitive neuroscience as well as molecular biology. Their work involves the study of enzyme function and inhibition, neurological disorders and treatments, including Parkinson's Disease mechanisms and treatments, and autism spectrum disorder research.

Among the recent papers authored by Pekka T. Männistö are:

  • The Catechol O-Methyltransferase Inhibitor Entacapone in the Treatment of Parkinson's Disease: Personal Reflections on a First-in-Class Drug Development Programme 40 Years On (2024, Neurology and Therapy)
  • COMT gene locus: new functional variants (2020, UNC Libraries)
  • Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain (2020, UNC Libraries)

Frequent coauthors include:

  • Shad B. Smith
  • William Maixner
  • Ilkka Reenilä
  • Luda Diatchenko
  • Tapani Keränen

Publication venues that commonly feature their work are:

  • UNC Libraries
  • Neurology and Therapy

The research scope of Pekka T. Männistö covers topics including:

  • Parkinson's Disease Mechanisms and Treatments
  • Neurological disorders and treatments
  • Autism Spectrum Disorder Research
  • Enzyme function and inhibition

Best Publications

  • Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.

    Pekka T. Männistö;Seppo Kaakkola

  • Neurotransmitter regulation of anterior pituitary hormones.

    J Tuomisto;P Männistö

  • Pharmacologically Diverse Antidepressants Rapidly Activate Brain-Derived Neurotrophic Factor Receptor TrkB and Induce Phospholipase-Cγ Signaling Pathways in Mouse Brain

    Tomi Rantamäki;Panu Hendolin;Aino Kankaanpää;Jelena Mijatovic

  • Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum.

    Leonid Yavich;Markus M. Forsberg;Maria Karayiorgou;Joseph A. Gogos

  • On the role of prolyl oligopeptidase in health and disease.

    J.A. García-Horsman;P.T. Männistö;P.T. Männistö;J.I. Venäläinen

  • Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors

    P. T. Männistö;I. Ulmanen;K. Lundström;J. Taskinen

  • Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice.

    Marko Huotari;Joseph A. Gogos;Maria Karayiorgou;Olli Koponen

  • Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

    Mikko Käenmäki;Anne Emilia Tammimäki;Timo Tapio Myöhänen;Kaisa Pakarinen

  • Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors.

    Reijo Backstrom;Erkki Honkanen;Aino Pippuri;Pekka Kairisalo

  • The multiple faces of quercetin in neuroprotection.

    Bernardino Ossola;Tiina M Kääriäinen;Pekka T Männistö

  • Amantadine protects dopamine neurons by a dual action: Reducing activation of microglia and inducing expression of GNDF in astroglia

    Bernardino Ossola;Nadia Schendzielorz;Shih-Heng Chen;Gary S. Bird

  • Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis

    Anne Tammimäki;Pekka T. Männistö

  • Rationale for Selective COMT Inhibitors as Adjuncts in the Drug Treatment of Parkinson's Disease

    P. T. Männistö;S. Kaakkola

  • General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase.

    Seppo Kaakkola;Ariel Gordin;Pekka T. Männistö

  • Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.

    Merja H. Voutilainen;Susanne Bäck;Johan Peränen;Päivi Lindholm

  • Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same

    Reijo J. Backstrom;Kalevi E. Heinola;Erkki J. Honkanen;Seppo K. Kaakkola

  • 7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety.

    Vallo Volke;Andres Soosaar;Sulev Kõks;Michel Bourin

  • New selective COMT inhibitors: useful adjuncts for Parkinson's disease?

    P.T. Männistö;S. Kaakkola

  • Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat

    Erkki Nissinen;Inge-Britt Lindén;Eija Schultz;Seppo Kaakkola

  • Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice

    Timo Tapio Myöhänen;Nadia Schendzielorz;Pekka Männistö

  • Evolutionary relationships of the prolyl oligopeptidase family enzymes.

    Jarkko I. Venäläinen;Risto O. Juvonen;Pekka T. Männistö

  • Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task

    Tiina Koskinen;Sirja Ruotsalainen;Tarja Puumala;Raimo Lappalainen

  • Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat.

    Pekka T. Männistö;Päivi Tuomainen;Raimo K. Tuominen

  • A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.

    T T Myöhänen;T T Myöhänen;M J Hannula;R Van Elzen;Melanie Gérard

  • Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route.

    J Mattila;P T Männistö;R Mäntylä;S Nykänen

  • Amantadine protects dopamine neurons by a dual action: Reducing activation of microglia and inducing expression of GNDF in astroglia

    Bernardino Ossola;Nadia Schendzielorz;Nadia Schendzielorz;Shih-Heng Chen;Gary S. Bird

Frequent Co-Authors

Eero Vasar
Eero Vasar University of Tartu
Sulev Kõks
Sulev Kõks Perron Institute for Neurological and Translational Science
Mart Saarma
Mart Saarma University of Helsinki
Jaanus Harro
Jaanus Harro University of Tartu
Tomasz Róg
Tomasz Róg University of Helsinki
Mikko Karttunen
Mikko Karttunen University of Western Ontario
Markku Mäki
Markku Mäki Tampere University
Katri Kaukinen
Katri Kaukinen Tampere University
Tomi Järvinen
Tomi Järvinen University of Eastern Finland
Veli-Matti Kosma
Veli-Matti Kosma University of Eastern Finland

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Chemistry in the USA opens doors to diverse career paths, many of which can be complemented by related online degree programs. For example, understanding the costs associated with a program is crucial when planning your education. You can explore this further by reviewing information on how much does a criminal justice degree cost, as budgeting and tuition fees often influence degree choices across fields.

If you’re considering ancillary qualifications, programs such as an accredited online criminal justice associate degree provide flexible options to gain credentials that may support roles in regulatory compliance or forensic chemistry.

Career pathways like becoming a paralegal can also intersect with scientific expertise. Understanding the financial benefits is helpful; for instance, insights into paralegal salary associate's degree reveal potential earnings and the value of related associate degrees in your overall strategy.

For those interested in the pharmaceutical side, combining a chemistry background with sales skills is a lucrative option. Learn about earning potential and requirements through resources on drug rep salary.

These examples highlight the benefits of exploring related degrees and career pathways online, offering flexibility and practical insights for chemistry graduates aiming to broaden their professional opportunities.

Best Scientists Citing Pekka T. Männistö

Trending Scientists

Recently Published Articles