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Charles J. Parker

Charles J. Parker

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
10020
World Ranking
16174
National Ranking
6701

Research.com Recognitions

  • 1959 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Charles J. Parker is affiliated with the University of Utah in the United States. Their research spans multiple fields, primarily focusing on Medicine and Biochemistry, Genetics and Molecular Biology. Their work engages extensively with subfields such as Molecular Biology, Pulmonary and Respiratory Medicine, Pediatrics, Perinatology and Child Health, Immunology, and Hematology.

The scientist's main topics of study include Porphyrin Metabolism and Disorders, Heme Oxygenase-1 and Carbon Monoxide, Prostate Cancer Treatment and Research, Neonatal Health and Biochemistry, Prostate Cancer Diagnosis and Treatment, Radiomics and Machine Learning in Medical Imaging, and the Complement System in Diseases.

Frequent collaborators in their research include Gerhardt Attard, Manisha Balwani, Herbert L. Bonkovsky, D. Montgomery Bissell, and Karl E. Anderson.

The publication venues where Charles J. Parker has published most often include:

  • New England Journal of Medicine
  • British Journal of Haematology
  • The American Journal of Gastroenterology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Lancet

Representative recent papers authored or coauthored by Parker emphasize clinical studies and trials in hepatology, oncology, and molecular therapeutics:

  • "Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria," 2020, New England Journal of Medicine
  • "The Lancet Commission on prostate cancer: planning for the surge in cases," 2024, The Lancet
  • "Efficacy and safety of givosiran for acute hepatic porphyria: 24-month interim analysis of the randomized phase 3 ENVISION study," 2021, Liver International
  • "Dersimelagon in Erythropoietic Protoporphyrias," 2023, New England Journal of Medicine
  • "1767MO External validation of a digital pathology-based multimodal artificial intelligence (MMAI)-derived model in high-risk localized (M0)/metastatic (M1) prostate cancer (PCa) starting androgen deprivation therapy (ADT) in the docetaxel (Doc) or abiraterone (AAP) phase III STAMPEDE trials," 2023, Annals of Oncology

Charles J. Parker was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1959.

Best Publications

  • Diagnosis and management of paroxysmal nocturnal hemoglobinuria.

    Charles Parker;Mitsuhiro Omine;Stephen Richards;Jun-Ichi Nishimura

  • Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria.

    M H Holguin;L R Fredrick;N J Bernshaw;L A Wilcox

  • Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria

    Manisha Balwani;Eliane Sardh;Paolo Ventura;Paula Aguilera Peiró

  • Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation.

    G D Ross;W J Yount;M J Walport;J B Winfield

  • Human immunodeficiency virus type 1 incorporates both glycosyl phosphatidylinositol-anchored CD55 and CD59 and integral membrane CD46 at levels that protect from complement-mediated destruction.

    Mohammed Saifuddin;Tarlan Hedayati;John P. Atkinson;Mark H. Holguin

  • Afamelanotide for Erythropoietic Protoporphyria

    J. G. Langendonk;M. Balwani;Karl Anderson;H. L. Bonkovsky

  • Host cell-derived complement control proteins CD55 and CD59 are incorporated into the virions of two unrelated enveloped viruses. Human T cell leukemia/lymphoma virus type I (HTLV-I) and human cytomegalovirus (HCMV).

    Gregory T. Spear;Nell S. Lurain;Charles J. Parker;Mahmood Ghassemi

  • Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria

    Eliane Sardh;Pauline Harper;Manisha Balwani;Penelope Stein

  • Eculizumab for paroxysmal nocturnal haemoglobinuria.

    Charles Parker

  • Activation of complement by hemodialysis membranes: polyacrylonitrile binds more C3a than cuprophan.

    Alfred K. Cheung;Charles J. Parker;Linda A. Wilcox;Jarmila Janatova

  • Relationship between the membrane inhibitor of reactive lysis and the erythrocyte phenotypes of paroxysmal nocturnal hemoglobinuria.

    M H Holguin;L A Wilcox;N J Bernshaw;W F Rosse

  • The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C.

    R. E. Whatley;P. Nelson;G. A. Zimmerman;D. L. Stevens

  • Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH).

    Norimitsu Inoue;Tomohisa Izui-Sarumaru;Yoshiko Murakami;Yuichi Endo

  • Molecular basis of the enhanced susceptibility of the erythrocytes of paroxysmal nocturnal hemoglobinuria to hemolysis in acidified serum.

    Linda A. Wilcox;John L. Ezzell;Nicole J. Bernshaw;Charles J. Parker

  • Paroxysmal nocturnal haemoglobinuria.

    Wendell F. Rosse;Charles J. Parker

  • Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain.

    P.L. McGeer;D.G. Walker;H. Akiyama;T. Kawamata

  • Vitronectin is a substrate for transglutaminases.

    David C. Sane;Tammy L. Moser;Anne M.M. Pippen;Charles J. Parker

  • EXPLORE: A Prospective, Multinational, Natural History Study of Patients with Acute Hepatic Porphyria with Recurrent Attacks

    Laurent Gouya;Paolo Ventura;Manisha Balwani;D. Montgomery Bissell

  • Liver transplantation in the management of porphyria

    Ashwani K. Singal;Charles Parker;Christine Bowden;Manish Thapar

  • The pathophysiology of paroxysmal nocturnal hemoglobinuria

    Charles J. Parker

Frequent Co-Authors

John D. Phillips
John D. Phillips University of Utah
Lawrie W. Powell
Lawrie W. Powell University of Queensland
Alfred K. Cheung
Alfred K. Cheung University of Utah
Robert J. Desnick
Robert J. Desnick Icahn School of Medicine at Mount Sinai
Gregory J. Anderson
Gregory J. Anderson QIMR Berghofer Medical Research Institute
Carl T. Wittwer
Carl T. Wittwer University of Utah
Katrina J. Allen
Katrina J. Allen University of Melbourne
John F. Bohnsack
John F. Bohnsack University of Utah
Taroh Kinoshita
Taroh Kinoshita Osaka University
Jaroslav Jelinek
Jaroslav Jelinek Coriell Institute For Medical Research

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