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Medicine

D-Index
109
Citations
53615
World Ranking
5701
National Ranking
227

Research.com Recognitions

  • 1994 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 1985 - Fellow of the Royal Society of Canada Academy of Science

Overview

Philip Seeman was affiliated with the University of Toronto in Canada throughout their career. Their research predominantly focused on the molecular and cellular mechanisms underlying neuroscience, particularly the biochemistry and genetics of neural receptors.

The main fields of study in Seeman's work included Biochemistry, Genetics and Molecular Biology as well as Neuroscience. More specifically, their contributions were centered in the subfields of Molecular Biology and Cellular and Molecular Neuroscience. The topics they explored most frequently were:

  • Receptor Mechanisms and Signaling
  • Neurotransmitter Receptor Influence on Behavior
  • Neuroscience and Neuropharmacology Research
  • Pharmacological Receptor Mechanisms and Effects

Seeman published research in several venues, with repeated contributions to the IUPHAR/BPS Guide to Pharmacology CITE. Other notable publication venues included ACS Chemical Neuroscience and Neuropsychopharmacology.

Some of their recent papers exemplify the focus of their research:

  • "The High Affinity Dopamine D2 Receptor Agonist MCL-536: A New Tool for Studying Dopaminergic Contribution to Neurological Disorders," 2021, ACS Chemical Neuroscience
  • "Dopamine receptors in GtoPdb v.2023.1," 2023, IUPHAR/BPS Guide to Pharmacology CITE
  • "Oleh Hornykiewicz-In Memoriam," 2020, Neuropsychopharmacology
  • "Dopamine receptors in GtoPdb v.2025.3," 2025, IUPHAR/BPS Guide to Pharmacology CITE

Throughout their career, Seeman collaborated frequently with other researchers, including Jean-Martin Beaulieu, Emiliana Borrelli, Arvid Carlsson, Marc G. Caron, and Olivier Civelli.

Seeman received recognition in their field, including the Robert J. and Claire Pasarow Foundation Medical Research Award in 1994. They were also elected a Fellow of the Royal Society of Canada in 1985 as part of the Academy of Science.

Best Publications

  • Brain dopamine receptors.

    P Seeman

  • Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.

    Hubert H. M. Van Tol;James R. Bunzow;Hong-Chang Guan;Roger K. Sunahara

  • Antipsychotic drug doses and neuroleptic/dopamine receptors

    P. Seeman;T. Lee;M. Chau-Wong;K. Wong

  • Does Fast Dissociation From the Dopamine D2 Receptor Explain the Action of Atypical Antipsychotics?: A New Hypothesis

    Shitij Kapur;Philip Seeman

  • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

    R. K. Sunahara;Hong-Chang Guan;B. F. O'dowd;P. Seeman

  • Radioreceptor binding profile of the atypical antipsychotic olanzapine

    Frank P Bymaster;David O Calligaro;Julie F Falcone;Richard D Marsh

  • Multiple dopamine D4 receptor variants in the human population

    Van Tol Hh;Wu Cm;Guan Hc;Ohara K

  • Atypical Antipsychotics: Mechanism of Action:

    Philip Seeman

  • Dopamine receptor pharmacology

    Philip Seeman;Hubert H.M. Van Tol

  • Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons

    P Seeman;T Lee

  • Dopamine receptors and the dopamine hypothesis of schizophrenia.

    Philip Seeman

  • Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

    P Seeman;M Chau-Wong;J Tedesco;K Wong

  • Dopamine D4 receptors elevated in schizophrenia

    Philip Seeman;Hong-Chang Guan;Hubert H. M. Van Tol

  • D1 and D2 dopamine receptor mRNA in rat brain

    David M. Weiner;Allan I. Levey;Roger K. Sunahara;Hyman B. Niznik

  • NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia.

    S Kapur;P Seeman

  • Human dopamine D1 receptor encoded by an intronless gene on chromosome 5.

    Roger K. Sunahara;Hyman B. Niznik;David M. Weiner;Tom M. Stormann

  • Receptor basis for dopaminergic supersensitivity in Parkinson's disease

    Tyrone Lee;P. Seeman;A. Rajput;Irene J. Farley

  • A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy.

    Shitij Kapur;Robert Zipursky;Corey Jones;C. S. Shammi

  • Human brain dopamine receptors in children and aging adults.

    Philip Seeman;Natalie H. Bzowej;H.-C. Guan;Catherine Bergeron

  • Binding of 3 H-neuroleptics and 3 H-apomorphine in schizophrenic brains

    Tyrone Lee;Philip Seeman;W. W. Tourtellotte;Irene J. Farley

Frequent Co-Authors

Shitij Kapur
Shitij Kapur King's College London
Hyman B. Niznik
Hyman B. Niznik University of Toronto
Hubert H. M. Van Tol
Hubert H. M. Van Tol University of Toronto
Susan R. George
Susan R. George University of Toronto
Alan A. Wilson
Alan A. Wilson Centre for Addiction and Mental Health
Brian F. O'Dowd
Brian F. O'Dowd Centre for Addiction and Mental Health
John L. Neumeyer
John L. Neumeyer Harvard University
Bertha K. Madras
Bertha K. Madras Harvard University
José N. Nobrega
José N. Nobrega Centre for Addiction and Mental Health
Roger K. Sunahara
Roger K. Sunahara University of California, San Diego

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Best Scientists Citing Philip Seeman