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D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
31320
World Ranking
7614
National Ranking
3463

Overview

Roger K. Sunahara is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and neuroscience. The work reflects a focus on molecular biology and cellular and molecular neuroscience, with additional interests that include spectroscopy, computational theory and mathematics, and cell biology.

The main topics covered in Sunahara's research include receptor mechanisms and signaling, neuropeptides and animal physiology, neuroscience and neuropharmacology research, protein kinase regulation and GTPase signaling, lipid membrane structure and behavior, photoreceptor and optogenetics research, and retinal development and disorders.

Recent publications by Sunahara showcase a range of studies addressing receptor structure and function, signaling pathways, and innovative optogenetic tools. Notable papers include:

  • Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane, 2020, Nature
  • Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling, 2021, Cell
  • Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR, 2020, Cell Research
  • A photoswitchable GPCR-based opsin for presynaptic inhibition, 2021, Neuron
  • Non-canonical β-adrenergic activation of ERK at endosomes, 2022, Nature

Sunahara has frequently published in several scientific journals. The venues with the most publications include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Communications
  • The FASEB Journal
  • Cell

Collaborations are an important aspect of Sunahara's research. Frequent co-authors include Mary J. Clark, Brian K. Kobilka, Harald Hübner, Peter Gmeiner, and Xinyu Xu. These collaborations indicate active engagement in multi-author research projects across the indicated fields.

Best Publications

  • Crystal structure of the β2 adrenergic receptor-Gs protein complex.

    Søren G. F. Rasmussen;Brian T. DeVree;Yaozhong Zou;Andrew C. Kruse

  • Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.

    Hubert H. M. Van Tol;James R. Bunzow;Hong-Chang Guan;Roger K. Sunahara

  • Structure of a nanobody-stabilized active state of the β2 adrenoceptor

    Søren G F Rasmussen;Hee Jung Choi;Juan Jose Fung;Els Pardon

  • Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

    Aashish Manglik;Andrew C. Kruse;Tong Sun Kobilka;Foon Sun Thian

  • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

    R. K. Sunahara;Hong-Chang Guan;B. F. O'dowd;P. Seeman

  • Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with Gsα·GTPγS

    John J. G. Tesmer;Roger K. Sunahara;Alfred G. Gilman;Stephen R. Sprang

  • Complexity and Diversity of Mammalian Adenylyl Cyclases

    Roger K. Sunahara;Carmen W. Dessauer;Alfred G. Gilman

  • Structure and function of an irreversible agonist-β2 adrenoceptor complex

    Daniel M. Rosenbaum;Cheng Zhang;Joseph A. Lyons;Joseph A. Lyons;Ralph Holl

  • HUMAN PARAOXONASES (PON1, PON2, AND PON3) ARE LACTONASES WITH OVERLAPPING AND DISTINCT SUBSTRATE SPECIFICITIES

    Dragomir I. Draganov;John F. Teiber;Audrey Speelman;Yoichi Osawa

  • Conformational biosensors reveal GPCR signalling from endosomes

    Roshanak Irannejad;Jin C. Tomshine;Jon R. Tomshine;Michael Chevalier

  • A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

    Matthew R. Whorton;Michael P. Bokoch;Søren G. F. Rasmussen;Bo Huang

  • Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies.

    Allan I. Levey;Steven M. Hersch;David B. Rye;Roger K. Sunahara

  • D1 and D2 dopamine receptor mRNA in rat brain

    David M. Weiner;Allan I. Levey;Roger K. Sunahara;Hyman B. Niznik

  • Human dopamine D1 receptor encoded by an intronless gene on chromosome 5.

    Roger K. Sunahara;Hyman B. Niznik;David M. Weiner;Tom M. Stormann

  • GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

    Alex R.B. Thomsen;Bianca Plouffe;Thomas J. Cahill;Arun K. Shukla

  • Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.

    Roger K. Sunahara;Ronald Taussig

  • Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.

    Ka Young Chung;Søren G. F. Rasmussen;Søren G. F. Rasmussen;Tong Liu;Sheng Li

  • Crystal structure of the adenylyl cyclase activator Gsalpha

    Roger K. Sunahara;John J. G. Tesmer;Alfred G. Gilman;Stephen R. Sprang

  • Two-Metal-Ion Catalysis in Adenylyl Cyclase

    John J. G. Tesmer;Roger K. Sunahara;Roger A. Johnson;Gilles Gosselin

  • Efficient Coupling of Transducin to Monomeric Rhodopsin in a Phospholipid Bilayer

    Matthew R. Whorton;Beata Elzbieta Jastrzebska;Paul Shin-Hyun Park;Dimitrios Fotiadis

Frequent Co-Authors

Brian K. Kobilka
Brian K. Kobilka Stanford University
James H. Woods
James H. Woods University of Michigan–Ann Arbor
Hyman B. Niznik
Hyman B. Niznik University of Toronto
John J. G. Tesmer
John J. G. Tesmer Purdue University West Lafayette
Jan Steyaert
Jan Steyaert Vrije Universiteit Brussel
Els Pardon
Els Pardon Vrije Universiteit Brussel
Richard R. Neubig
Richard R. Neubig Michigan State University
David E. Shaw
David E. Shaw D. E. Shaw Research
William I. Weis
William I. Weis Stanford University
Alfred G. Gilman
Alfred G. Gilman The University of Texas Southwestern Medical Center

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