John J. G. Tesmer

Overview

Best Publications

• Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with Gsα·GTPγS

  John J. G. Tesmer;Roger K. Sunahara;Alfred G. Gilman;Stephen R. Sprang

  1149
  Citations

• Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

  John J.G. Tesmer;David M. Berman;Alfred G. Gilman;Stephen R. Sprang

  1016
  Citations

• G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.

  Eugenia V. Gurevich;John J.G. Tesmer;Arcady Mushegian;Vsevolod V. Gurevich

  501
  Citations

• Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ

  David T. Lodowski;Julie A. Pitcher;Julie A. Pitcher;Julie A. Pitcher;W. Darrell Capel;W. Darrell Capel;W. Darrell Capel;Robert J. Lefkowitz;Robert J. Lefkowitz;Robert J. Lefkowitz

  465
  Citations

• Crystal structure of the adenylyl cyclase activator Gsalpha

  Roger K. Sunahara;John J. G. Tesmer;Alfred G. Gilman;Stephen R. Sprang

  413
  Citations

• Snapshot of Activated G Proteins at the Membrane: The Gαq-GRK2-Gßγ Complex

  Valerie M. Tesmer;Takeharu Kawano;Aruna Shankaranarayanan;Tohru Kozasa

  394
  Citations

• Two-Metal-Ion Catalysis in Adenylyl Cyclase

  John J. G. Tesmer;Roger K. Sunahara;Roger A. Johnson;Gilles Gosselin

  382
  Citations

• The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.

  J.J Tesmer;T.J Klem;M.L Deras;V.J Davisson

  301
  Citations

• Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases.

  Roger K. Sunahara;Annie Beuve;John J.G. Tesmer;Stephen R. Sprang

  283
  Citations

• Structure of Gαq-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs

  Susanne Lutz;Aruna Shankaranarayanan;Aruna Shankaranarayanan;Cassandra Coco;Marc Ridilla;Marc Ridilla

  264
  Citations

• Feedback Inhibition of G Protein-coupled Receptor Kinase 2 (GRK2) Activity by Extracellular Signal-regulated Kinases

  J. A. Pitcher;J. J. G. Tesmer;J. L. R. Freeman;W. D. Capel

  240
  Citations

• Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding *□

  Timothy H. Bayburt;Sergey A. Vishnivetskiy;Mark A. McLean;Takefumi Morizumi

  237
  Citations

• Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

  Sarah M. Schumacher;Erhe Gao;Weizhong Zhu;Xiongwen Chen

  236
  Citations

• Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.

  David M. Thal;Kristoff T. Homan;Jun Chen;Emily K. Wu

  211
  Citations

• Identification of a Giα Binding Site on Type V Adenylyl Cyclase

  Carmen W. Dessauer;John J.G. Tesmer;John J.G. Tesmer;Stephen R. Sprang;Stephen R. Sprang;Alfred G. Gilman

  192
  Citations

• STRUCTURE AND FUNCTION OF HETEROTRIMERIC G PROTEIN-REGULATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS

  Mohamed Aittaleb;Cassandra A. Boguth;John J. G. Tesmer

  187
  Citations

• Structural Determinants of RhoA Binding and Nucleotide Exchange in Leukemia-associated Rho Guanine-Nucleotide Exchange Factor

  Romana Kristelly;Guang Gao;John J.G. Tesmer

  182
  Citations

• The structure, catalytic mechanism and regulation of adenylyl cyclase

  John J.G. Tesmer;Stephen R. Sprang

  175
  Citations

• Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central α-Helical Domain

  Qianzhi Li;Mark R. Nance;Rima Kulikauskas;Kevin Nyberg

  150
  Citations

• G Protein-Coupled Receptor Kinases

  Vsevolod V. Gurevich;Eugenia V. Gurevich;John J.G. Tesmer

  4
  Citations