What is he best known for?
The fields of study he is best known for:
James A. Shayman spends much of his time researching Biochemistry, Ceramide, Cell biology, Enzyme and Lipid signaling.
His study in Biochemistry focuses on Phospholipase A2, Enzyme inhibitor, Metabolism, Diglyceride and Sphingomyelin.
His studies in Ceramide integrate themes in fields like Sphingosine, Sphingolipid, Endogeny and Cell growth.
His Enzyme study combines topics in areas such as Glycosylation, Stereochemistry and Eliglustat.
In his research, Glycosphingolipid is intimately related to GlcCer synthase, which falls under the overarching field of Stereochemistry.
His research investigates the connection with Lipid signaling and areas like Second messenger system which intersect with concerns in Tumor necrosis factor alpha, Cellular differentiation, Heat shock, Heat shock protein and Membrane lipids.
His most cited work include:
- Improved inhibitors of glucosylceramide synthase. (265 citations)
- (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase (208 citations)
- Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth. (170 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Biochemistry, Ceramide, Endocrinology, Internal medicine and Cell biology.
His Biochemistry study frequently involves adjacent topics like Molecular biology.
His research in Ceramide intersects with topics in Lipid signaling, Sphingomyelin, Sphingosine, Phospholipase D and Stereochemistry.
His study in Endocrinology is interdisciplinary in nature, drawing from both Fabry disease, Globotriaosylceramide and Immunology.
His work in Sphingolipid addresses subjects such as Polycystic kidney disease, which are connected to disciplines such as Eliglustat.
His Enzyme course of study focuses on Glycosphingolipid and Cell growth.
He most often published in these fields:
- Biochemistry (47.28%)
- Ceramide (23.91%)
- Endocrinology (19.57%)
What were the highlights of his more recent work (between 2012-2020)?
- Biochemistry (47.28%)
- Enzyme (14.67%)
- Internal medicine (19.57%)
In recent papers he was focusing on the following fields of study:
His main research concerns Biochemistry, Enzyme, Internal medicine, Endocrinology and Fabry disease.
His study in the fields of Phospholipase A2, Histidine and ATP synthase under the domain of Enzyme overlaps with other disciplines such as Glycoside Hydrolase Inhibitors.
His work investigates the relationship between Internal medicine and topics such as Signal transduction that intersect with problems in Muscle hypertrophy and Diabetic nephropathy.
In general Endocrinology, his work in Adipose tissue, White adipose tissue, Carbohydrate metabolism and Adipose tissue macrophages is often linked to FGF21 linking many areas of study.
His work in the fields of Fabry disease, such as Globotriaosylceramide, overlaps with other areas such as Von Willebrand factor.
His Globotriaosylceramide research includes themes of Molecular biology and Gene.
Between 2012 and 2020, his most popular works were:
- Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism (95 citations)
- DRUG INDUCED PHOSPHOLIPIDOSIS: AN ACQUIRED LYSOSOMAL STORAGE DISORDER (84 citations)
- Ceramides and Glucosylceramides are independent antagonists of insulin signaling (83 citations)
In his most recent research, the most cited papers focused on:
James A. Shayman focuses on Biochemistry, Enzyme, Phospholipase, Internal medicine and Endocrinology.
His work on Cholesterol, Recombinant DNA and CD1 as part of general Biochemistry study is frequently linked to Reverse cholesterol transport and Fish-Eye Disease, bridging the gap between disciplines.
James A. Shayman works mostly in the field of Enzyme, limiting it down to concerns involving Phospholipid and, occasionally, Metabolism, Substrate reduction therapy and Lysosomal storage disease.
James A. Shayman has researched Phospholipase in several fields, including Phospholipase A2 and Cell biology.
As a part of the same scientific study, he usually deals with the Internal medicine, concentrating on Signal transduction and frequently concerns with Kidney, Muscle hypertrophy, Lactosylceramides and Diabetes mellitus.
His work in the fields of Endocrinology, such as White adipose tissue, Carbohydrate metabolism, Adipose tissue macrophages and Adipocyte, intersects with other areas such as FGF21.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
