Member of the Association of American Physicians
James A. Shayman spends much of his time researching Biochemistry, Ceramide, Cell biology, Enzyme and Lipid signaling. His study in Biochemistry focuses on Phospholipase A2, Enzyme inhibitor, Metabolism, Diglyceride and Sphingomyelin. His studies in Ceramide integrate themes in fields like Sphingosine, Sphingolipid, Endogeny and Cell growth.
His Enzyme study combines topics in areas such as Glycosylation, Stereochemistry and Eliglustat. In his research, Glycosphingolipid is intimately related to GlcCer synthase, which falls under the overarching field of Stereochemistry. His research investigates the connection with Lipid signaling and areas like Second messenger system which intersect with concerns in Tumor necrosis factor alpha, Cellular differentiation, Heat shock, Heat shock protein and Membrane lipids.
His primary areas of investigation include Biochemistry, Ceramide, Endocrinology, Internal medicine and Cell biology. His Biochemistry study frequently involves adjacent topics like Molecular biology. His research in Ceramide intersects with topics in Lipid signaling, Sphingomyelin, Sphingosine, Phospholipase D and Stereochemistry.
His study in Endocrinology is interdisciplinary in nature, drawing from both Fabry disease, Globotriaosylceramide and Immunology. His work in Sphingolipid addresses subjects such as Polycystic kidney disease, which are connected to disciplines such as Eliglustat. His Enzyme course of study focuses on Glycosphingolipid and Cell growth.
His main research concerns Biochemistry, Enzyme, Internal medicine, Endocrinology and Fabry disease. His study in the fields of Phospholipase A2, Histidine and ATP synthase under the domain of Enzyme overlaps with other disciplines such as Glycoside Hydrolase Inhibitors. His work investigates the relationship between Internal medicine and topics such as Signal transduction that intersect with problems in Muscle hypertrophy and Diabetic nephropathy.
In general Endocrinology, his work in Adipose tissue, White adipose tissue, Carbohydrate metabolism and Adipose tissue macrophages is often linked to FGF21 linking many areas of study. His work in the fields of Fabry disease, such as Globotriaosylceramide, overlaps with other areas such as Von Willebrand factor. His Globotriaosylceramide research includes themes of Molecular biology and Gene.
James A. Shayman focuses on Biochemistry, Enzyme, Phospholipase, Internal medicine and Endocrinology. His work on Cholesterol, Recombinant DNA and CD1 as part of general Biochemistry study is frequently linked to Reverse cholesterol transport and Fish-Eye Disease, bridging the gap between disciplines. James A. Shayman works mostly in the field of Enzyme, limiting it down to concerns involving Phospholipid and, occasionally, Metabolism, Substrate reduction therapy and Lysosomal storage disease.
James A. Shayman has researched Phospholipase in several fields, including Phospholipase A2 and Cell biology. As a part of the same scientific study, he usually deals with the Internal medicine, concentrating on Signal transduction and frequently concerns with Kidney, Muscle hypertrophy, Lactosylceramides and Diabetes mellitus. His work in the fields of Endocrinology, such as White adipose tissue, Carbohydrate metabolism, Adipose tissue macrophages and Adipocyte, intersects with other areas such as FGF21.
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Improved inhibitors of glucosylceramide synthase.
Lihsueh Lee;Akira Abe;James A. Shayman.
Journal of Biological Chemistry (1999)
(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase
Alicja Bielawska;Mathew S. Greenberg;David Perry;Supriya Jayadev.
Journal of Biological Chemistry (1996)
Ganglioside-Linked Terminal Sialic Acid Moieties on Murine Macrophages Function as Attachment Receptors for Murine Noroviruses
Stefan Taube;Jeffrey W. Perry;Kristen Yetming;Sagar P. Patel.
Journal of Virology (2009)
Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase CORRELATION WITH CYCLIN-DEPENDENT KINASES
C. S. Sheela Rani;Akira Abe;Yan Chang;Nitsa Rosenzweig.
Journal of Biological Chemistry (1995)
Improved inhibitors of glucosylceramide synthase.
Akira Abe;Jin-ichi Inokuchi;Masayuki Jimbo;Hiroshi Shimeno.
Journal of Biochemistry (1992)
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease
Kerry Anne McEachern;John Fung;Svetlana Komarnitsky;Craig S. Siegel.
Molecular Genetics and Metabolism (2007)
Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.
A. Abe;N. S. Radin;J. A. Shayman;L. L. Wotring.
Journal of Lipid Research (1995)
Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells.
Jin Song Shen;Xing Li Meng;Xing Li Meng;David F. Moore;Jane M. Quirk.
Molecular Genetics and Metabolism (2008)
Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation
Akira Abe;Susan Gregory;Lihsueh Lee;Paul D. Killen.
Journal of Clinical Investigation (2000)
The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion
Vania Tz. Hinkovska-Galcheva;Laurence A. Boxer;Pamela J. Mansfield;Donna Harsh.
Journal of Biological Chemistry (1998)
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