World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
10856
World Ranking
11018
National Ranking
4763

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

James A. Shayman is affiliated with the University of Michigan-Ann Arbor in the United States.

Shayman's research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine. Their work includes contributions to subfields such as physiology, molecular biology, genetics, cell biology, and organic chemistry.

The scientist's research topics cover a range of biochemical and cellular processes, including:

  • Lysosomal Storage Disorders Research
  • Carbohydrate Chemistry and Synthesis
  • Cellular Transport and Secretion
  • Sphingolipid Metabolism and Signaling
  • Calcium Signaling and Nucleotide Metabolism
  • Lipid Metabolism and Biosynthesis
  • Adipose Tissue and Metabolism

Frequent co-authors in their publications include:

  • Akira Abe
  • Vania Hinkovska-Galcheva
  • Jonathan M. Shillingford
  • Liming Shu
  • Ying Li

The most common publication venues where Shayman's research has appeared are:

  • Journal of Lipid Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Gastroenterology
  • Cell Metabolism

Recent notable papers include:

  • "Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis," 2021, Journal of Lipid Research
  • "Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk," 2023, Gastroenterology
  • "Optimization of Eliglustat-Based Glucosylceramide Synthase Inhibitors as Substrate Reduction Therapy for Gaucher Disease Type 3," 2020, ACS Chemical Neuroscience
  • "The role of lysosomal phospholipase A2 in the catabolism of bis(monoacylglycerol)phosphate and association with phospholipidosis," 2024, Journal of Lipid Research
  • "Inhibitors of Glucosylceramide Synthase," 2023, Methods in Molecular Biology

James A. Shayman has been recognized as a member of the Association of American Physicians.

Best Publications

  • Improved inhibitors of glucosylceramide synthase.

    Lihsueh Lee;Akira Abe;James A. Shayman

  • (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase

    Alicja Bielawska;Mathew S. Greenberg;David Perry;Supriya Jayadev

  • Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells.

    Jin Song Shen;Xing Li Meng;Xing Li Meng;David F. Moore;Jane M. Quirk

  • Ganglioside-Linked Terminal Sialic Acid Moieties on Murine Macrophages Function as Attachment Receptors for Murine Noroviruses

    Stefan Taube;Jeffrey W. Perry;Kristen Yetming;Sagar P. Patel

  • Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase CORRELATION WITH CYCLIN-DEPENDENT KINASES

    C. S. Sheela Rani;Akira Abe;Yan Chang;Nitsa Rosenzweig

  • Improved inhibitors of glucosylceramide synthase.

    Akira Abe;Jin-ichi Inokuchi;Masayuki Jimbo;Hiroshi Shimeno

  • A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease

    Kerry Anne McEachern;John Fung;Svetlana Komarnitsky;Craig S. Siegel

  • Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

    A. Abe;N. S. Radin;J. A. Shayman;L. L. Wotring

  • Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation

    Akira Abe;Susan Gregory;Lihsueh Lee;Paul D. Killen

  • Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.

    Bhagirath Chaurasia;Vincent Andre Kaddai;Graeme Iain Lancaster;Darren C. Henstridge

  • Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

    Thomas A Natoli;Laurie A Smith;Kelly A Rogers;Bing Wang

  • The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion

    Vania Tz. Hinkovska-Galcheva;Laurence A. Boxer;Pamela J. Mansfield;Donna Harsh

  • Amino ceramide-like compounds and therapeutic methods of use

    James A. Shayman;Norman S. Radin

  • Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP‐Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth

    Steven B Levery;Michelle Momany;Rebecca Lindsey;Marcos S Toledo

  • DRUG INDUCED PHOSPHOLIPIDOSIS: AN ACQUIRED LYSOSOMAL STORAGE DISORDER

    James A. Shayman;Akira Abe

  • Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase

    Pamela J. Mansfield;James A. Shayman;Laurence A. Boxer

  • Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase.

    Miki Hiraoka;Akira Abe;James A. Shayman

  • Ceramides and Glucosylceramides are independent antagonists of insulin signaling

    Jose A. Chavez;M. Mobin Siddique;Siew Tein Wang;Jianhong Ching

  • Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances

    Radin Ns;Shayman Ja;Inokuchi J

  • Ceramide-1-phosphate: A mediator of phagocytosis

    Vania Hinkovska-Galcheva;Laurence A Boxer;Andrei L Kindzelskii;Miki Hiraoka

Frequent Co-Authors

Norman S. Radin
Norman S. Radin University of Michigan–Ann Arbor
Laurence A. Boxer
Laurence A. Boxer University of Michigan–Ann Arbor
John J. G. Tesmer
John J. G. Tesmer Purdue University West Lafayette
Scott D. Larsen
Scott D. Larsen University of Michigan–Ann Arbor
Johannes M. F. G. Aerts
Johannes M. F. G. Aerts Leiden University
Scott A. Summers
Scott A. Summers University of Utah
Howard R. Petty
Howard R. Petty University of Michigan–Ann Arbor
John Marshall
John Marshall Sanofi (United States)
Aubrey R. Morrison
Aubrey R. Morrison Washington University in St. Louis
Lucia Mori
Lucia Mori University of Basel

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Expanding your study in Biology and Biochemistry opens pathways to diverse careers in the healthcare and life sciences sectors. Many students consider dietetics masters programs to specialize in nutrition, wellness, and diet management. This can lead to roles such as registered dietitian or clinical nutritionist.

For those interested in clinical support roles, online medical assistant programs fafsa approved offer flexible learning and financial aid options, preparing graduates for entry-level positions in healthcare settings.

Advancing further, current medical assistants may consider transitioning to nursing by enrolling in cma to lpn programs, which provide a streamlined path to become a Licensed Practical Nurse.

Those seeking a faster route to a science degree can explore online biology degrees that allow completion at an accelerated pace. These options enable learners to balance their studies with work or family obligations while progressing toward graduate study or professional opportunities.

Best Scientists Citing James A. Shayman

Trending Scientists

Recently Published Articles