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Biology and Biochemistry

D-Index
54
Citations
10789
World Ranking
15617
National Ranking
6513

Overview

Myles C. Cabot is affiliated with East Carolina University in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions in medicine. The scientist's work spans several subfields, including molecular biology, hematology, oncology, immunology, and pharmacology.

The main research topics covered by Myles C. Cabot include acute myeloid leukemia research, sphingolipid metabolism and signaling, mitochondrial function and pathology, ATP synthase and ATPases research, drug transport and resistance mechanisms, DNA repair mechanisms, and the pharmacological effects of natural compounds.

Recent publications demonstrate a focus on cellular bioenergetics, cancer resistance mechanisms, and therapeutic enhancements utilizing sphingolipids. Notable papers include:

  • Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia, 2021, eLife
  • On the nature of ceramide-mitochondria interactions - Dissection using comprehensive mitochondrial phenotyping, 2020, Cellular Signalling
  • A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer, 2020, Experimental Cell Research
  • Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia, 2022, Blood Reviews
  • Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia, 2022, The FASEB Journal

Collaboration forms a notable part of their work, with frequent coauthors including Su-Fern Tan, David J. Feith, Kelsey H. Fisher-Wellman, Thomas P. Loughran, and James T. Hagen. These repeated partnerships indicate sustained research networks in related biomedical fields.

Myles C. Cabot has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), The FASEB Journal, Cancers, Cellular Signalling, and eLife. Their contributions to these journals reflect ongoing engagement with molecular biology and cancer research communities.

Best Publications

  • Ceramide-orchestrated signalling in cancer cells

    Samy A. F. Morad;Myles C. Cabot

  • Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

    Wenjing Zheng;Jessica Kollmeyer;Holly Symolon;Amin Momin

  • Targeting Ceramide Metabolism—a Strategy for Overcoming Drug Resistance

    Alex Senchenkov;David A. Litvak;Myles C. Cabot

  • Ceramide glycosylation potentiates cellular multidrug resistance

    Yong-Yu Liu;Tie-Yan Han;Armando E. Giuliano;Myles C. Cabot

  • Expression of Glucosylceramide Synthase, Converting Ceramide to Glucosylceramide, Confers Adriamycin Resistance in Human Breast Cancer Cells

    Yong-Yu Liu;Tie-Yan Han;Armando E. Giuliano;Myles C. Cabot

  • Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism

    Barry J. Maurer;Lisa Melton;Carolyn Billups;Myles C. Cabot

  • Glucosylceramide: a marker for multiple-drug resistant cancers.

    Anthony Lucci;Won I. Cho;Tie Yan Han;Armando E. Giuliano

  • Glucosylceramide Synthase Blockade Down-Regulates P-Glycoprotein and Resensitizes Multidrug-Resistant Breast Cancer Cells to Anticancer Drugs

    Valérie Gouazé;Yong-Yu Liu;Carlton S. Prickett;Jing Y. Yu

  • Taxol-induced ceramide generation and apoptosis in human breast cancer cells

    Anthony G. Charles;Tie-Yan Han;Yong Y. Liu;Nora Hansen

  • Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.

    Valerie Gouazé;Jing Y. Yu;Richard J. Bleicher;Tie-Yan Han

  • Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

    Yong-Yu Liu;Vineet Gupta;Gauri A Patwardhan;Kaustubh Bhinge

  • Glucosylceramide synthase and apoptosis.

    Richard J. Bleicher;Myles C. Cabot

  • A role for ceramide in driving cancer cell resistance to doxorubicin

    Yong-Yu Liu;Jing Yuan Yu;Dongmei Yin;Gauri Anand Patwardhan

  • N-(4-Hydroxyphenyl)retinamide Elevates Ceramide in Neuroblastoma Cell Lines by Coordinate Activation of Serine Palmitoyltransferase and Ceramide Synthase

    Hongtao Wang;Barry J. Maurer;C. Patrick Reynolds;Myles C. Cabot

  • Glycosphingolipids and drug resistance.

    Valerie Gouaze-Andersson;Myles C. Cabot

  • Identification of Phosphatidylcholine-selective and Phosphatidylinositol-selective Phospholipases D in Madin-Darby Canine Kidney Cells*

    Chunfa Huang;R. L. Wykle;L. W. Daniel;M. C. Cabot

  • Tamoxifen retards glycosphingolipid metabolism in human cancer cells.

    Myles C. Cabot;Armando E. Giuliano;Alon Volner;Tie-Yan Han

  • Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells.

    Valérie Gouazé-Andersson;Jing Y. Yu;Adam J. Kreitenberg;Alicja Bielawska

  • SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells.

    Myles C. Cabot;Armando E. Giuliano;Tie-Yan Han;Yong-Yu Liu

  • Ceramide Signaling in Fenretinide-induced Endothelial Cell Apoptosis

    Anat Erdreich-Epstein;Linda B. Tran;Nina N. Bowman;Hongtao Wang

Frequent Co-Authors

Armando E. Giuliano
Armando E. Giuliano Cedars-Sinai Medical Center
Thomas P. Loughran
Thomas P. Loughran University of Virginia
Hong-Gang Wang
Hong-Gang Wang Pennsylvania State University
Josefina Casas
Josefina Casas Spanish National Research Council
Shantu Amin
Shantu Amin Pennsylvania State University
Timothy Kottke
Timothy Kottke Mayo Clinic
S. Michal Jazwinski
S. Michal Jazwinski Tulane University
P. Darrell Neufer
P. Darrell Neufer East Carolina University
Xin Liu
Xin Liu Chinese Academy of Sciences

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