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Biology and Biochemistry

D-Index
64
Citations
15835
World Ranking
9596
National Ranking
4237

Overview

P. Darrell Neufer is affiliated with East Carolina University in the United States and conducts research primarily in the intersecting fields of biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields, including molecular biology, physiology, cell biology, cardiology and cardiovascular medicine, and surgery.

Their research focuses extensively on mitochondrial function and pathology, adipose tissue and metabolism, and ATP synthase and ATPases. Additionally, they explore topics related to muscle metabolism and nutrition, metabolism and genetic disorders, as well as sphingolipid metabolism and signaling. Cancer, hypoxia, and metabolism also feature among their main scientific interests.

Neufer has contributed to the following peer-reviewed publications:

  • From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies, 2021, Journal of Biological Chemistry
  • Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction, 2023, JAMA Cardiology
  • Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation, 2022, Molecular Metabolism
  • Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis, 2022, The FASEB Journal
  • Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner, 2020, The FASEB Journal

Frequent coauthors of Neufer include:

  • Kelsey H. Fisher-Wellman
  • Cameron A. Schmidt
  • Chien-Te Lin
  • James T. Hagen
  • Espen E. Spangenburg

Neufer has published repeatedly in the following venues:

  • Journal of Biological Chemistry
  • The FASEB Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • eLife

Best Publications

  • Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

    Ethan J. Anderson;Mary E. Lustig;Kristen E. Boyle;Tracey L. Woodlief

  • Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle

    Henriette Pilegaard;Bengt Saltin;P. Darrell Neufer

  • Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise

    Henriette Pilegaard;Henriette Pilegaard;George A. Ordway;Bengt Saltin;P. Darrell Neufer

  • Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content

    Charlotte Keller;Adam Steensberg;Henriette Pilegaard;Takuya Osada

  • Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

    P. Darrell Neufer;Marcas M. Bamman;Deborah Marie Muoio;Claude Bouchard

  • Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

    Ethan J. Anderson;Alan P. Kypson;Evelio Rodriguez;Curtis A. Anderson

  • Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training.

    Loretta DiPietro;James Dziura;Catherine W. Yeckel;P. Darrell Neufer

  • Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

    Deborah M. Muoio;P. Darrell Neufer

  • Linking mitochondrial bioenergetics to insulin resistance via redox biology

    Kelsey H. Fisher-Wellman;P. Darrell Neufer

  • Type II skeletal myofibers possess unique properties that potentiate mitochondrial H2O2 generation

    Ethan J. Anderson;P. Darrell Neufer

  • Effects of α-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle

    Sebastian B. Jørgensen;Jørgen F. P. Wojtaszewski;Benoit Viollet;Fabrizio Andreelli

  • Influence of pre‐exercise muscle glycogen content on exercise‐induced transcriptional regulation of metabolic genes

    Henriette Pilegaard;Charlotte Keller;Adam Steensberg;Jørn Wulff Helge

  • Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.

    J. Julie Wu;Rachel J. Roth;Ethan J. Anderson;Eun-Gyoung Hong

  • Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle.

    Henriette Pilegaard;Bengt Saltin;P. Darrell Neufer

  • Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies.

    Carsten Lundby;Nikolai Nordsborg;Keiko Kusuhara;Kristina Møller Kristensen

  • Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice.

    Li Kang;Julio E. Ayala;Robert S. Lee-Young;Zhonghua Zhang

  • Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise

    Henriette Pilegaard;Takuya Osada;Lisbeth T. Andersen;Jørn W. Helge

  • Methods for Assessing Mitochondrial Function in Diabetes

    Christopher G.R. Perry;Daniel A. Kane;Ian R. Lanza;P. Darrell Neufer

  • Regulation of Gene Expression in Skeletal Muscle by Contractile Activity

    R. Sanders Williams;P. Darrell Neufer

  • Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle

    Christopher G. R. Perry;Daniel A. Kane;Chien-Te Lin;Rachel Kozy

Frequent Co-Authors

Bengt Saltin
Bengt Saltin University of Copenhagen
David H. Wasserman
David H. Wasserman Vanderbilt University
Deborah M. Muoio
Deborah M. Muoio Duke University
Joseph A. Houmard
Joseph A. Houmard East Carolina University
Richard P. Bazinet
Richard P. Bazinet University of Toronto
R. Sanders Williams
R. Sanders Williams Duke University
Joan Clària
Joan Clària Hospital Clinic of Barcelona
Myles C. Cabot
Myles C. Cabot East Carolina University
Robert A. Kloner
Robert A. Kloner Huntington Medical Research Institutes
Bente Klarlund Pedersen
Bente Klarlund Pedersen University of Copenhagen

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