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Chemistry

D-Index
44
Citations
6471
World Ranking
16936
National Ranking
690

Overview

Josefina Casas is affiliated with the Spanish National Research Council in Spain. Their research spans medicine and biochemistry, genetics, and molecular biology, with a focus on various subfields including molecular biology, physiology, cell biology, public health, environmental and occupational health, and immunology.

The scientist's work covers a diverse range of topics notably including sphingolipid metabolism and signaling, lysosomal storage disorders research, mosquito-borne diseases and control, carbohydrate chemistry and synthesis, autophagy in disease and therapy, HIV research and treatment, and lipid membrane structure and behavior.

Josefina Casas has published research in several frequent academic venues, notably:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Redox Biology
  • Brain

Frequent collaborators contributing significantly to Casas's scientific output include Gemma Fabriàs, José Luís Abad, Mireia Casasampere, Antonio Delgado, and José Luís Corchero.

Among recent research contributions, some notable papers include:

  • "The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells" (2020) published in Autophagy
  • "Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD" (2020) published in The FASEB Journal
  • "Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology" (2022) published in npj Parkinson's Disease
  • "Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders" (2021) published in Journal of Extracellular Vesicles
  • "Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV-1 Env Clustering" (2020) published in Advanced Science

Best Publications

  • Inhibitors of sphingolipid metabolism enzymes.

    Antonio Delgado;Josefina Casas;Amadeu Llebaria;José Luís Abad

  • Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells.

    Paola Signorelli;Jose M. Munoz-Olaya;Vincenzo Gagliostro;Josefina Casas

  • Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells.

    Eva Gorrochategui;Elisabet Pérez-Albaladejo;Josefina Casas;Sílvia Lacorte

  • Fructose-6-phosphate aldolase in organic synthesis: preparation of D-fagomine, N-alkylated derivatives, and preliminary biological assays

    José A. Castillo;Jordi Calveras;Josefina Casas;Montserrat Mitjans

  • Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.

    Patricia Gangoiti;Luz Camacho;Lide Arana;Alberto Ouro

  • Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization.

    S Hernández-Tiedra;G Fabriàs;D Davila;Íj Salanueva

  • Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines.

    Daniel Canals;David Mormeneo;David Mormeneo;Gemma Fabriàs;Amadeu Llebaria

  • Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology.

    Fabio Simbari;Jana McCaskill;Gillian Coakley;Marissa Millar

  • Dihydroceramide desaturase and dihydrosphingolipids: Debutant players in the sphingolipid arena

    Gemma Fabrias;Jose Muñoz-Olaya;Francesca Cingolani;Paola Signorelli

  • Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells.

    Chiara Ullio;Josefina Casas;Ulf T. Brunk;Giuseppina Sala

  • Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1

    Nuria Izquierdo-Useros;Maier Lorizate;F. Xabier Contreras;Maria T. Rodriguez-Plata

  • Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains.

    Catarina R. Vieira;Jose M. Munoz-Olaya;Jesús Sot;Sonia Jiménez-Baranda

  • Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy.

    Vincenzo Gagliostro;Josefina Casas;Anna Caretti;Jose L. Abad

  • C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth

    Margaret Flowers;Gemma Fabriás;Antonio Delgado;Antonio Delgado;Josefina Casas

  • Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase.

    Jose M. Munoz-Olaya;Xavier Matabosch;Carmen Bedia;Meritxell Egido-Gabás

  • On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.

    E. Ellen Jones;Shaalee Dworski;Daniel Canals;Josefina Casas

  • Click Chemistry Approach to New N-Substituted Aminocyclitols as Potential Pharmacological Chaperones for Gaucher Disease†

    Lucía Díaz;Jordi Bujons;Josefina Casas;Amadeu Llebaria

  • Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II.

    Francesca Cingolani;Mireia Casasampere;Pol Sanllehí;Josefina Casas

  • Synthesis of a Novel Ceramide Analogue and its Use in a High‐Throughput Fluorogenic Assay for Ceramidases

    Carmen Bedia;Josefina Casas;Virginie Garcia;Thierry Levade

  • Chemoenzymatic Synthesis and Inhibitory Activities of Hyacinthacines A1 and A2 Stereoisomers

    Jordi Calveras;Josefina Casas;Teodor Parella;Jesús Joglar

Frequent Co-Authors

Thierry Levade
Thierry Levade Paul Sabatier University
Riccardo Ghidoni
Riccardo Ghidoni University of Milan
José C. Fernández-Checa
José C. Fernández-Checa University of Southern California
Jeffrey A. Medin
Jeffrey A. Medin Medical College of Wisconsin
Guillermo Velasco
Guillermo Velasco Complutense University of Madrid
Antonio Zorzano
Antonio Zorzano University of Barcelona
Evelina Gatti
Evelina Gatti Aix-Marseille University
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Sergio Lavandero
Sergio Lavandero University of Chile
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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